Identification of Senescent Cells in the Bone Microenvironment [PDF]
Journal of Bone and Mineral Research, 2016 ABSTRACT Cellular senescence is a fundamental mechanism by which cells remain metabolically active yet cease dividing and undergo distinct phenotypic alterations, including upregulation of p16Ink4a, profound secretome changes, telomere shortening, and decondensation of pericentromeric satellite DNA.
Joshua N, Farr +13 more
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The Role of Immune Microenvironment in Maxillofacial Bone Homeostasis
Frontiers in Dental Medicine, 2021 Maxillofacial bone defects are common medical problems caused by congenital defects, necrosis, trauma, tumor, inflammation, and fractures non-union. Maxillofacial bone defects often need bone graft, which has many difficulties, such as limited autogenous
Na Li +13 more
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, 2022 SIMPLE SUMMARY: Multiple myeloma is a haematological malignancy due to a proliferation of clonal plasma cells. The medullary milieu consists of a bone marrow microenvironment comprising an assortment of cells and structures supporting blood cell ...
Allegra, Alessandro +9 more
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Advances in Molecular Mechanisms of Early Bone Metastasis
Zhongliu Fangzhi Yanjiu, 2019 Bone metastasis is a common complication of malignant tumors. Breast cancer and lung cancer are mostly with osteolytic bone metastases. The clinical manifestations of bone metastasis are pain, hypercalcemia, pathological fractures, etc., seriously ...
MAO Yun +4 more
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Implantation of silicon dioxide-based nanocrystalline hydroxyapatite and pure phase beta-tricalciumphosphate bone substitute granules in caprine muscle tissue does not induce new bone formation [PDF]
, 2013 Background: Osteoinductive bone substitutes are defined by their ability to induce new bone formation even at heterotopic implantation sites. The present study was designed to analyze the potential osteoinductivity of two different bone substitute ...
Künzel, Oliver +13 more
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Regulatory interactions in the bone marrow microenvironment [PDF]
IBMS BoneKEy, 2011 Hematopoietic stem cells (HSCs) are the immature, pluripotent cells from which all myeloid and lymphoid cell types originate. As stem cells, HSCs are capable of two very different fate choices: self-renewal, ensuring they will persist throughout the lifetime of an organism, and differentiation to mature progeny. Therapeutic applications of HSCs include
Julianne N, Smith, Laura M, Calvi
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Characterization of tenascin-W, an emerging player in the metastatic bone marrow niche [PDF]
, 2015 Tumors are heterogeneous organ-like tissues including not only tumor cells themselves but also auxiliary cells such as, endothelial cells, fibroblasts, inflammatory cells, and bone marrow derived stem or stromal cells (BMSCs), which collectively create ...
Chiovaro, Francesca
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Bone Microenvironment‐Suppressed T Cells Increase Osteoclast Formation and Osteolytic Bone Metastases in Mice [PDF]
, 2022 Immunotherapies use components of the immune system, such as T cells, to fight cancer cells, and are changing cancer treatment, causing durable responses in some patients.
Felipe Olvera +24 more
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Bone Marrow Microenvironment-On-Chip for Culture of Functional Hematopoietic Stem Cells
Frontiers in Bioengineering and Biotechnology, 2022 Hematopoiesis takes place in the bone marrow and is supported by a complex cellular and molecular network in the bone marrow microenvironment. Commonly used models of the human bone marrow microenvironment include murine models and two-dimensional and ...
Azmeer Sharipol +8 more
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Mesenchymal Differentiation and Organ Distribution of Established Human Stromal Cell Lines in NOD/SCID Mice [PDF]
, 2001 Two human stromal cell lines were established previously from bone marrow-derived primary long-term cultures by immortalization using the SV40 large T antigen and cellular cloning. After irradiation, the fibroblast-like cell lines L87/4 and L88/5 support
Thalmeier, Karin +6 more
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