Results 51 to 60 of about 1,264,713 (295)
Advances on the roles of tumor microenvironment in bone cancer pain [PDF]
Jichu yixue yu linchuang, 2021 Tumor microenvironment (TME) is the in vitro microenvironment in which tumors live. Cancer-induced bone pain(CIBP) is one of the most common symptoms of tumor bone metastasis.
ZHOU Jia-hong, LI Min
doaj
Isolation and characterization of mesenchymal stem cells from cultured human pancreatic islets of langerhans [PDF]
, 2006 Replacement of insulin producing β-cells that reside within pancreatic islets represents an almost ideal treatment for patients with diabetes mellitus type 1.
Eberhardt, Michael
core +1 more source
Bone Metastatic Breast Cancer: Advances in Cell Signaling and Autophagy Related Mechanisms
, 2021 Bone metastasis is a frequent complication of breast cancer with nearly 70% of metastatic breast cancer patients developing bone metastasis during the course of their disease.
Jitesh Pratap +5 more
core +1 more source
Adjusting bone mass for differences in projected bone area and other confounding variables: an allometric perspective. [PDF]
, 2002 The traditional method of assessing bone mineral density (BMD; given by bone mineral content [BMC] divided by projected bone area [Ap], BMD = BMC/Ap) has come under strong criticism by various authors. Their criticism being that the projected bone "area"
Roger L. Holder +20 more
core +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Contribution of immune cells to bone metastasis pathogenesis
Frontiers in Endocrinology, 2022 Bone metastasis is closely related to the survival rate of cancer patients and reduces their quality of life. The bone marrow microenvironment contains a complex immune cell component with a local microenvironment that is conducive to tumor formation and
Ningning He +4 more
doaj +1 more source
‘Educated’ Osteoblasts Reduce Osteoclastogenesis in a Bone-Tumor Mimetic Microenvironment
, 2021 Breast cancer (BC) metastases to bone disrupt the balance between osteoblasts and osteoclasts, leading to excessive bone resorption. We identified a novel subpopulation of osteoblasts with tumor-inhibitory properties, called educated osteoblasts (EOs ...
Evan T. Keller +3 more
core +1 more source
FEBS Letters, EarlyView.Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise +5 more
wiley +1 more source
Bioactive Materials, 2021 The fate of cells and subsequent bone regeneration is highly correlated with temporospatial coordination of chemical, biological, or physical cues within a local tissue microenvironment.
Jie Shen +11 more
doaj +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source