Results 61 to 70 of about 372,366 (297)

Expression of the IL-11 Gene in Metastatic Cells Is Supported by Runx2-Smad and Runx2-cJun Complexes Induced by TGFβ1. [PDF]

, 2015
In tumor cells, two factors are abnormally increased that contribute to metastatic bone disease: Runx2, a transcription factor that promotes expression of metastasis related and osteolytic genes; and IL-11, a secreted osteolytic cytokine.
Afzal, Akech, Ali, Aqeilan, Bamba, Begley, Buijs, Calon, Campbell, Casimiro, D'Alonzo, Deng, Dutta, Eswaraka, Fradet, Furuya, Gordon, Hess, Huang, Ikushima, Iranikhah, Javed, Kamradt, Kang, Koeneman, Lay, Leong, Massague, Mathew, Matsumoto, Matsumura, McCoy, Mendoza-Villanueva, Morrissey, Necula, Ortiz, Padua, Pratap, Pratap, Pratap, Schroeder, Selvamurugan, Shen, Sottnik, Stein, Tang, Tang, Tohjima, van der Deen, Wan, Weilbaecher, Xiang, Yang, Yang, Yang, Young, Zaidi, Zhang, Zhang, Zurita   +59 more
core   +2 more sources

Treatment of Bone Metastasis

Current Oncology, 2022
The incidence of metastatic bone disease is increasing, as patients with cancer are living longer [...]
openaire   +3 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

The host microenvironment influences prostate cancer invasion, systemic spread, bone colonization, and osteoblastic metastasis

Frontiers in Oncology, 2014
Prostate cancer (PCa) is the second leading cause of cancer death in men worldwide. Most PCa patients die with osteoblastic bone metastases. What triggers PCa metastasis to the bone and what causes osteoblastic lesions remain unanswered.
Sourik S Ganguly, Xiaohong eLi, Cindy K Miranti   +2 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Clinical characteristics and prognoses in pediatric neuroblastoma with bone or liver metastasis: data from the SEER 2010–2019

BMC Pediatrics
Background To investigate clinical characteristics, prognoses, and impacts of treatments on prognoses of neuroblastoma patients with bone or liver metastasis. Methods This retrospective cohort study extracted data from the Surveillance, Epidemiology, and
Xudong Zhao, Zhuofan Xu, Xiaochuan Feng
doaj   +1 more source

Hypomagnesemia and vitamin D deficiency complicating bisphosphonate induced hypocalcaemia [PDF]

, 2012
Zolendronic acid is a potent bisphosphonate that is used to treat patients with metastatic cancer by reducing bone pain and preventing skeletal complications of bone metastasis.
Bigeni, Josephine, Vella, Antoine
core  

Pain and analgesic use associated with skeletal-related events in patients with advanced cancer and bone metastases [PDF]

, 2005
PURPOSE: Bone metastases secondary to solid tumors increase the risk of skeletal-related events (SREs), including the occurrence of pathological fracture (PF), radiation to bone (RB), surgery to bone (SB), and spinal cord compression (SCC).
Roger von Moos, Jean-Jacques Body, Blair Egerdie, Alison Stopeck, Janet Brown, Lesley Fallowfield, Donald L. Patrick, Charles Cleeland, Danail Damyanov, Felipe Salvador Palazzo, Gavin Marx, Ying Zhou, Ada Braun, Arun Balakumaran, Yi Qian, RE Coleman, RE Coleman, R Moos von, S Vadhan-Raj, GR Mundy, GD Roodman, JA Ford, A Lipton, F Saad, LS Rosen, L Costa, CS Cleeland, K Lemay, CS Cleeland, M Maltoni, L Costa, CS Cleeland, R Moos von, L Costa, AT Stopeck, K Fizazi, DH Henry, D Henry, GV Scagliotti, A Lipton, CS Cleeland, KC Chung, DF Cella, K Webster, N Sathiakumar, N Sathiakumar, K Fizazi, M Yong, M Norgaard, K Cetin, C Nieder, E Chow, MR Smith, A Hussain, AM Abdulhalim, G Oster   +55 more
core   +4 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Clinical Significance of Has_circ_0060937 in Bone Metastasis of NSCLC

International Journal of General Medicine, 2020
Jiangnan Zhang,1 Wenwei Mao,2 Zhe Chen,2 Haiting Gu,2 Chan Lian2 1Orthopedics, The First People’s Hospital of Wenling, Wenling, Zhejiang, People’s Republic of China; 2Department of Respiratory and Critical Care Medicine, The First People ...
Zhang J, Mao W, Chen Z, Gu H, Lian C
doaj