Results 51 to 60 of about 372,366 (297)

miR-204-5p Represses Bone Metastasis via Inactivating NF-κB Signaling in Prostate Cancer

Molecular Therapy: Nucleic Acids, 2019
The prime issue derived from prostate cancer (PCa) is its high prevalence to metastasize to bone. MicroRNA-204-5p (miR-204-5p) has been reported to be involved in the development and metastasis in a variety of cancers.
Qingde Wa, Sheng Huang, Jincheng Pan, Yubo Tang, Shaofu He, Xiaodong Fu, Xinsheng Peng, Xiao Chen, Chunxiao Yang, Dong Ren, Yan Huang, Zhuangwen Liao, Shuai Huang, Changye Zou   +13 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Peran Terapi Akupunktur pada Nyeri Tulang Metastasis

Indonesian Journal of Cancer, 2016
Bone pain caused by cancer is a common complication in bone metastasis. Bone pain has the characteristic triad of pain including continuous pain, spontaneous pain and incident pain.
HASAN MIHARDJA, ZULHAFIZ MUFTI AGUNG
doaj   +1 more source

Animal models of bone metastasis [PDF]

Cancer, 2003
Animal models will continue to be indispensable to investigate the pathogenesis of bone metastasis in vivo, conduct preclinical chemotherapeutic, chemoprevention and genetic therapy studies, test gene delivery mechanisms, and identify metastasis suppressor and inducer genes.
Thomas J, Rosol, Sarah H, Tannehill-Gregg, Bruce E, LeRoy, Stefanie, Mandl, Christopher H, Contag   +4 more
openaire   +4 more sources

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Bone metastasis prediction in non-small-cell lung cancer: primary CT-based radiomics signature and clinical feature

BMC Medical Imaging
Background Radiomics provided opportunities to quantify the tumor phenotype non-invasively. This study extracted contrast-enhanced computed tomography (CECT) radiomic signatures and evaluated clinical features of bone metastasis in non-small-cell lung ...
Zheng Liu, Rui Yin, Wenjuan Ma, Zhijun Li, Yijun Guo, Haixiao Wu, Yile Lin, Vladimir P. Chekhonin, Karl Peltzer, Huiyang Li, Min Mao, Xiqi Jian, Chao Zhang   +12 more
doaj   +1 more source

Breast Cancer Associated Metastasis is Significantly Increased in a Model of Autoimmune Arthritis [PDF]

, 2008
Chronic inflammation is known to play a role in cancer initiation, promotion,and metastasis. However, the mechanism by which inflammation promotes metastasis is still unclear.
Latha Pathangey, Lopamudra Das Roy, Pinku Mukherjee, Teresa Tinder   +3 more
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Bone metastasis and skeletal-related events in patients with solid cancer: A Korean nationwide health insurance database study.

PLoS ONE, 2020
Bone is one of the most common sites of metastasis from advanced solid tumors. Bone metastasis is a leading cause of pain and increases the risk of skeletal-related events (SREs) in cancer patients.
Soojung Hong, Taemi Youk, Su Jin Lee, Kyoung Min Kim, Claire M Vajdic   +4 more
doaj   +1 more source