Results 51 to 60 of about 264,729 (304)

Survival Analysis in Gastrointestinal Neuroendocrine Carcinoma With Bone Metastasis at Diagnosis

Frontiers in Surgery, 2022
PurposeGastrointestinal neuroendocrine carcinoma (NEC) with bone metastasis is rarely reported. The purpose of this study is to explore the prognosis and risk factors of such patients.Patients and MethodsWe retrospectively reviewed patients diagnosed as ...
Genlian Chen, Qiang Xu, Shengjun Qian, Zhan Wang, Shicheng Wang   +4 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

miR-204-5p Represses Bone Metastasis via Inactivating NF-κB Signaling in Prostate Cancer

Molecular Therapy: Nucleic Acids, 2019
The prime issue derived from prostate cancer (PCa) is its high prevalence to metastasize to bone. MicroRNA-204-5p (miR-204-5p) has been reported to be involved in the development and metastasis in a variety of cancers.
Qingde Wa, Sheng Huang, Jincheng Pan, Yubo Tang, Shaofu He, Xiaodong Fu, Xinsheng Peng, Xiao Chen, Chunxiao Yang, Dong Ren, Yan Huang, Zhuangwen Liao, Shuai Huang, Changye Zou   +13 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Engineering a biomimetic three-dimensional nanostructured bone model for breast cancer bone metastasis study

, 2015
Traditional breast cancer (BrCa) bone metastasis models contain many limitations with regards to controllability, reproducibility and flexibility of design. In this study, a novel biomimetic bone microenvironment was created by integrating hydroxyapatite
Fu, Y., Zhang, L.G., Wang, Mian, Castro, Nathan J., Castro, N.J., Wang, M., Fu, Yebo, Zhang, Lijie Grace, Zhu, Wei, Fu, Sidney W, Fu, Sidney W., Castro, Nathan J, Zhu, W., Fu, S.W.   +13 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

How Do Bisphosphonates Inhibit Bone Metastasis In Vivo? [PDF]

, 2010
"Bisphosphonates are potent inhibitors of osteoclast-mediated bone resorption and have demonstrated clinical utility in the treatment of patients with osteolytic bone metastases.
PIERRICK GERARD JEAN FOURNIER
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Bone metastasis prediction in non-small-cell lung cancer: primary CT-based radiomics signature and clinical feature

BMC Medical Imaging
Background Radiomics provided opportunities to quantify the tumor phenotype non-invasively. This study extracted contrast-enhanced computed tomography (CECT) radiomic signatures and evaluated clinical features of bone metastasis in non-small-cell lung ...
Zheng Liu, Rui Yin, Wenjuan Ma, Zhijun Li, Yijun Guo, Haixiao Wu, Yile Lin, Vladimir P. Chekhonin, Karl Peltzer, Huiyang Li, Min Mao, Xiqi Jian, Chao Zhang   +12 more
doaj   +1 more source

Peran Terapi Akupunktur pada Nyeri Tulang Metastasis

Indonesian Journal of Cancer, 2016
Bone pain caused by cancer is a common complication in bone metastasis. Bone pain has the characteristic triad of pain including continuous pain, spontaneous pain and incident pain.
HASAN MIHARDJA, ZULHAFIZ MUFTI AGUNG
doaj   +1 more source