Results 31 to 40 of about 372,366 (297)
The Cancer Diaspora: Metastasis beyond the seed and soil hypothesis [PDF]
, 2013 Do cancer cells escape their confinement of their original habitat in the primary tumor or are they forced out by ecological changes in their home niche?
Coffey, Donald S. +3 more
core +1 more source
Chinese Journal of Lung Cancer, 2013 Background and objective Bone metastasis is common in lung cancer patients. The β isomer of the C-terminal telopeptide of type I collagen (β-CTX) and bone-specific alkaline phosphates (BAP) are regarded as important bone turnover markers in bone ...
Qiong TANG +3 more
doaj +1 more source
Molecular dissection of the mechanism by which EWS/FLI expression compromises actin cytoskeletal integrity and cell adhesion in Ewing sarcoma. [PDF]
, 2014 Ewing sarcoma is the second-most-common bone cancer in children. Driven by an oncogenic chromosomal translocation that results in the expression of an aberrant transcription factor, EWS/FLI, the disease is typically aggressive and micrometastatic upon ...
Beckerle, Mary C +8 more
core +1 more source
Trends in Bone Metastasis Modeling [PDF]
Cancers, 2020 Bone is one of the most common sites for cancer metastasis. Bone tissue is composed by different kinds of cells that coexist in a coordinated balance. Due to the complexity of bone, it is impossible to capture the intricate interactions between cells under either physiological or pathological conditions.
Laranga R. +5 more
openaire +4 more sources
Osteocyte-Driven Downregulation of Snail Restrains Effects of Drd2 Inhibitors on Mammary Tumor Cells [PDF]
, 2018 While bone is a frequent target of breast cancer-associated metastasis, little is known about the effects of tumor-bone interactions on the efficacy of tumor-suppressing agents.
Chen, Andy +8 more
core +1 more source
NKX2-8/PTHrP Axis-Mediated Osteoclastogenesis and Bone Metastasis in Breast Cancer
Frontiers in Oncology, 2022 Bone metastasis is one of the most common distant metastasis of breast cancer, which could cause serious skeletal disease and increased cancer-related death.
Ainiwaerjiang Abudourousuli +15 more
doaj +1 more source
TGF-β2 dictates disseminated tumour cell fate in target organs through TGF-β-RIII and p38α/β signalling [PDF]
, 2013 In patients, non-proliferative disseminated tumour cells (DTCs) can persist in the bone marrow (BM) while other organs (such as lung) present growing metastasis.
Aguirre Ghiso, Julio A. +7 more
core +2 more sources
Hallmarks of Bone Metastasis [PDF]
Calcified Tissue International, 2017 Breast cancer bone metastasis develops as the result of a series of complex interactions between tumor cells, bone marrow cells, and resident bone cells. The net effect of these interactions are the disruption of normal bone homeostasis, often with significantly increased osteoclast and osteoblast activity, which has provided a rational target for ...
Rachelle W. Johnson, Larry J. Suva
openaire +2 more sources
Zhongliu Fangzhi Yanjiu, 2019 Objective To investigate the relationship between tumor markers of lung cancer and bone metastasis of whole body bone imaging in lung adenocarcinoma. Methods The whole body bone imaging of 278 patients diagnosed as lung adenocarcinoma in our hospital was
CAO Zhongnian +5 more
doaj +1 more source
Journal of Experimental & Clinical Cancer Research, 2019 Background Clinically, prostate cancer (PCa) exhibits a high avidity to metastasize to bone. Myc-associated zinc-finger protein (MAZ) is a well-documented oncogene involved in the progression and metastasis of multiple cancer types, even in PCa. However,
Qing Yang +9 more
doaj +1 more source