Results 31 to 40 of about 264,729 (304)

Mortality following bone metastasis and skeletal-related events among patients 65 years and above with lung cancer: A population-based analysis of U.S. Medicare beneficiaries, 1999-2006

Lung India, 2013
Background: To quantify the impact of bone metastasis and skeletal-related events (SREs) on mortality among older patients with lung cancer. Materials and Methods: Using the linked Surveillance, Epidemiology and End Results-Medicare database, we ...
Nalini Sathiakumar, Elizabeth Delzell, Michael A Morrisey, Carla Falkson, Mellissa Yong, Victoria Chia, Justin Blackburn, Tarun Arora, Meredith L Kilgore   +8 more
doaj   +1 more source

FAIM2 Promotes Non-Small Cell Lung Cancer Cell Growth and Bone Metastasis by Activating the Wnt/β-Catenin Pathway

Frontiers in Oncology, 2021
AimBone metastasis is the major reason for the poor prognosis and high mortality rate of non-small cell lung cancer (NSCLC) patients. This study explored the function and underlying mechanism of Fas apoptotic inhibitory molecule 2 (FAIM2) in the bone ...
Kelin She, Kelin She, Kelin She, Kelin She, Wensheng Yang, Mengna Li, Mengna Li, Mengna Li, Wei Xiong, Wei Xiong, Wei Xiong, Ming Zhou, Ming Zhou, Ming Zhou   +13 more
doaj   +1 more source

Bone-targeted nanoplatform enables efficient modulation of bone tumor microenvironment for prostate cancer bone metastasis treatment

, 2022
As there is currently no effective therapy for patients with prostate cancer (PCa) bone metastasis, it was stringent to explore the relevant treatment strategies.
Tingting Zhang (264633), Jingwen Huang (232382), Hui Wang (30400), Shulong Jiang (4686271), Qingbin Liu (210724), Lu Yao (444605), Xiangyu Zhang (630437), Pei Gao (706102)   +7 more
core   +1 more source

The CDK4/6 Inhibitor Palbociclib Inhibits Estrogen-Positive and Triple Negative Breast Cancer Bone Metastasis In Vivo [PDF]

, 2023
CDK 4/6 inhibitors have demonstrated significant improved survival for patients with estrogen receptor (ER) positive breast cancer (BC). However, the ability of these promising agents to inhibit bone metastasis from either ER+ve or triple negative BC ...
Wilson, Caroline, Ottewell, P.D., Caroline Wilson, Saleh, Lubaid, Wood, Steve L, Janet E. Brown, Park, C., Ingunn Holen, Park, Catherine, Brown, J.E., Ottewell, Penelope D, Brown, N.J., Brown, Janet E, Steve L. Wood, Wilson, C., Nichola J. Brown, Wood, S.L., Ali, S., Simak Ali, Lubaid Saleh, Holen, I., Penelope D. Ottewell, Saleh, L., Brown, Nichola J, Holen, Ingunn, Catherine Park, Ali, Simak   +26 more
core   +1 more source

Animal models of bone metastasis [PDF]

Cancer, 2003
Animal models will continue to be indispensable to investigate the pathogenesis of bone metastasis in vivo, conduct preclinical chemotherapeutic, chemoprevention and genetic therapy studies, test gene delivery mechanisms, and identify metastasis suppressor and inducer genes.
Thomas J, Rosol, Sarah H, Tannehill-Gregg, Bruce E, LeRoy, Stefanie, Mandl, Christopher H, Contag   +4 more
openaire   +4 more sources

Characterization of tenascin-W, an emerging player in the metastatic bone marrow niche [PDF]

, 2015
Tumors are heterogeneous organ-like tissues including not only tumor cells themselves but also auxiliary cells such as, endothelial cells, fibroblasts, inflammatory cells, and bone marrow derived stem or stromal cells (BMSCs), which collectively create ...
Chiovaro, Francesca
core   +1 more source

Formation of pre-metastatic bone niche in prostate cancer and regulation of traditional chinese medicine

Frontiers in Pharmacology, 2022
Prostate cancer with bone metastasis has a high cancer-specific mortality. Thus, it is essential to delineate the mechanism of bone metastasis. Pre-metastatic niche (PMN) is a concept in tumor metastasis, which is characterized by tumor-secreted factors,
Chiwei Chen, Renlun Huang, Jianfu Zhou, Lang Guo, Songtao Xiang   +4 more
doaj   +1 more source

Pain as an indicator of bone metastasis [PDF]

Acta Radiologica, 1988
Patients with breast or prostate cancer routinely referred for bone scintigraphy were evaluated for the presence of skeletal pain, as determined by a self administered questionnaire. Pain was a common finding, whether or not metastatic disease was present, and occurred in over half of patients.
E, Palmer, B, Henrikson, K, McKusick, H W, Strauss, F, Hochberg   +4 more
openaire   +2 more sources

Correlation of the Levels of the Bone Turnover Markers BAP and β-CTX with Bone Metastasis Progress in Lung Cancer Patients

Chinese Journal of Lung Cancer, 2013
Background and objective Bone metastasis is common in lung cancer patients. The β isomer of the C-terminal telopeptide of type I collagen (β-CTX) and bone-specific alkaline phosphates (BAP) are regarded as important bone turnover markers in bone ...
Qiong TANG, Hui ZHAO, Rui JIA, Linlin LIU   +3 more
doaj   +1 more source

NKX2-8/PTHrP Axis-Mediated Osteoclastogenesis and Bone Metastasis in Breast Cancer

Frontiers in Oncology, 2022
Bone metastasis is one of the most common distant metastasis of breast cancer, which could cause serious skeletal disease and increased cancer-related death.
Ainiwaerjiang Abudourousuli, Ainiwaerjiang Abudourousuli, Suwen Chen, Suwen Chen, Yameng Hu, Yameng Hu, Wanying Qian, Wanying Qian, Xinyi Liao, Xinyi Liao, Yingru Xu, Yingru Xu, Libing Song, Shuxia Zhang, Jun Li, Jun Li   +15 more
doaj   +1 more source