Results 21 to 30 of about 372,366 (297)
Effects of RANKL-Targeted Therapy in Immunity and Cancer. [PDF]
, 2014 The role of the receptor activator of nuclear factor-κB ligand (RANKL)/RANK system is well characterized within bone, where RANKL/RANK signaling mediates osteoclastogenesis and bone resorption.
Cheng, Michael L, Fong, Lawrence
core +2 more sources
Macrophages and bone metastasis
Journal of Experimental Medicine, 2023 In the prostate bone metastasis microenvironment, macrophages activate a cascade that involves Activin A, the extracellular matrix, and SRC kinase and drives resistance to anti-androgen therapy. These findings (Li et al., 2023. J. Exp. Med.https://doi.org/10.1084/jem.20221007) have broad implications, including metastasis diversity in different tissue ...
Diletta Di Mitri +2 more
openaire +2 more sources
BMC Cancer, 2021 Background Early screening and intervention therapies are crucial to improve the prognosis of hepatocellular carcinoma (HCC) patients with bone metastasis. We aimed to identify serum lncRNA as a prediction biomarker in HCC bone metastasis.
Li Zhang +6 more
doaj +1 more source
Zhongliu Fangzhi Yanjiu, 2022 Objective To evaluate the value of the systemic immune-inflammatory index (SII), CEA, Cyfra21-1, and NSE in predicting and diagnosing bone metastasis of lung cancer. Methods The clinical data of 618 patients with lung cancer were retrospectively analyzed.
TANG Min, LI Guixiang
doaj +1 more source
Dissecting Tumor-Stromal Interactions in Breast Cancer Bone Metastasis [PDF]
Endocrinology and Metabolism, 2016 Bone metastasis is a frequent occurrence in breast cancer, affecting more than 70% of late stage cancer patients with severe complications such as fracture, bone pain, and hypercalcemia.
Yibin Kang
doaj +1 more source
PTH1R-CaSR Cross Talk: New Treatment Options for Breast Cancer Osteolytic Bone Metastases. [PDF]
, 2018 Metastatic breast cancer (BrCa) is currently incurable despite great improvements in treatment of primary BrCa. The incidence of skeletal metastases in advanced BrCa occurs up to 70%.
Wang, Bin, Yang, Yanmei
core +2 more sources
Frontiers in Oncology, 2021 AimBone metastasis is the major reason for the poor prognosis and high mortality rate of non-small cell lung cancer (NSCLC) patients. This study explored the function and underlying mechanism of Fas apoptotic inhibitory molecule 2 (FAIM2) in the bone ...
Kelin She +13 more
doaj +1 more source
Lung India, 2013 Background: To quantify the impact of bone metastasis and skeletal-related events (SREs) on mortality among older patients with lung cancer. Materials and Methods: Using the linked Surveillance, Epidemiology and End Results-Medicare database, we ...
Nalini Sathiakumar +8 more
doaj +1 more source
Status and future directions of anti-metastatic cancer nanomedicines for the inhibition of cathepsin L [PDF]
, 2020 Angiogenesis, tissue invasion and metastasis in the tumour microenvironment are all critical hallmarks of cancer. Upregulation of cathepsin L plays an important role in angiogenesis and metastasis through its ability to degrade the extracellular matrix ...
Pranjol, Md Zahidul I +3 more
core +2 more sources
Frontiers in Pharmacology, 2022 Prostate cancer with bone metastasis has a high cancer-specific mortality. Thus, it is essential to delineate the mechanism of bone metastasis. Pre-metastatic niche (PMN) is a concept in tumor metastasis, which is characterized by tumor-secreted factors,
Chiwei Chen +4 more
doaj +1 more source