Tocilizumab but not Siltuximab prevents systemic inflammation in a humanized mouse model [PDF]
Frontiers in ImmunologyObjectivesThe present study aimed to assess the therapeutic efficacy of neutralizing monoclonal antibodies targeting a prominent proinflammatory cytokine in a PBMC transfer-induced humanized mouse model of systemic inflammation.MethodsInflammatory ...
Liang Zhang +13 more
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Infectious Medicine, 2023 Background: West Nile virus is a severe zoonotic pathogen that can cause severe central nervous system symptoms in humans and horses, and is fatal for birds, chickens and other poultry. With no specific drugs or vaccines available, antibody-based therapy
Meng-Jie Yang +8 more
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A Review of Therapeutic Antibodies in Breast Cancer
Journal of Pharmacy & Pharmaceutical Sciences, 2021 Since the first production of monoclonal antibodies about 35 years ago, researchers have found them useful in the treatment and diagnosis of various diseases such as cancer.
Maryam Eini +4 more
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Human monoclonal antibodies and monoclonal antibody multispecificity [PDF]
British Journal of Cancer, 1987 The majority of human anti-tumour monoclonal antibodies (Mabs) isolated to date have been disappointing. Firstly, they react or cross react with intracellular cytoskeletal proteins or nuclear antigens and therefore are of limited value as blood borne agents.
A M, Campbell, P, Whitford, R E, Leake
openaire +2 more sources
Unique allergen-specific human IgE monoclonal antibodies derived from patients with allergic disease
Frontiers in Allergy, 2023 IntroductionAllergic reactions are mediated by human IgE antibodies that bind to and cross-link allergen molecules. The sites on allergens that are recognized by IgE antibodies have been difficult to investigate because of the paucity of IgE antibodies ...
Bryan R. E. Smith +11 more
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Novel Clostridium difficile Anti-Toxin (TcdA and TcdB) Humanized Monoclonal Antibodies Demonstrate In Vitro Neutralization across a Broad Spectrum of Clinical Strains and In Vivo Potency in a Hamster Spore Challenge Model. [PDF]
PLoS ONE, 2016 Clostridium difficile (C. difficile) infection (CDI) is the main cause of nosocomial antibiotic-associated colitis and increased incidence of community-associated diarrhea in industrialized countries.
Hongyu Qiu +17 more
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New and Old Anti-CD20 Monoclonal Antibodies for Nephrotic Syndrome. Where We Are?
Frontiers in Immunology, 2022 Nephrotic proteinuria is the hallmark of several glomerulonephritis determined by different pathogenetic mechanisms, including autoimmune, degenerative and inflammatory.
Biswanath Basu +5 more
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Neutralizing Anti-Rituximab Antibodies and Relapse in Membranous Nephropathy Treated With Rituximab
Frontiers in Immunology, 2020 Membranous Nephropathy (MN) is an autoimmune disease associated with antibodies against podocyte proteins: M-type phospholipase A2 receptor (PLA2R1) or thrombospondin type-1 domain-containing 7A (THSD7A) in 70 and 3% of patients, respectively.
Sonia Boyer-Suavet +13 more
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A humanized anti-VEGF rabbit monoclonal antibody inhibits angiogenesis and blocks tumor growth in xenograft models. [PDF]
PLoS ONE, 2010 Rabbit antibodies have been widely used in research and diagnostics due to their high antigen specificity and affinity. Though these properties are also highly desirable for therapeutic applications, rabbit antibodies have remained untapped for human ...
Yanlan Yu +13 more
doaj +1 more source
Biosafety and Health, 2019 Antibodies are ideal for controlling the influenza A virus, but their effect on newly emerging strains is unclear. Here, we assessed the neutralization activity of the humanized monoclonal antibodies (mAbs) F10, H98 and H40 against circulating influenza ...
Jing Liu +10 more
doaj +1 more source