RANK and RANK ligand expression in primary human osteosarcoma [PDF]
Journal of Bone Oncology, 2015 Receptor activator of nuclear factor kappa-B ligand (RANKL) is an essential mediator of osteoclast formation, function and survival. In patients with solid tumor metastasis to the bone, targeting the bone microenvironment by inhibition of RANKL using ...
Daniel Branstetter +7 more
doaj +4 more sources
RANK-Ligand inhibitor associated osteonecrosis of the jaw [PDF]
GMS Interdisciplinary Plastic and Reconstructive Surgery DGPW, 2013 Osteonecrosis of the jaw may be caused by many different triggers. One of them is described to be the drug or medication related osteonecrosis of the jaw. Since many years bisphosphonates induced the dreaded diagnosis.
Rashad, Ashkan +2 more
doaj +5 more sources
Changes in Serum Dickkopf-1, RANK Ligand, Osteoprotegerin, and Bone Mineral Density after Allogeneic Hematopoietic Stem Cell Transplantation Treatment [PDF]
Endocrinology and Metabolism, 2021 Background Dickkopf-1 (DKK1) regulates bone formation by inhibiting canonical Wnt/β-catenin pathway signaling, and indirectly enhances osteoclastic activity by altering the expression ratio of receptor activator of nuclear factor-κB ligand (RANKL ...
Eunhee Jang +3 more
doaj +2 more sources
Correlating RANK Ligand/RANK Binding Kinetics With Osteoclast Formation and Function [PDF]
Journal of Cellular Biochemistry, 2015 ABSTRACTThe interaction between Receptor Activator of NF‐κB Ligand (RANKL) and its receptor RANK is essential for the differentiation and bone resorbing capacity of the osteoclast. Osteoprotegerin (OPG), a soluble homodimer, acts as a decoy receptor for RANKL and thus inhibits osteoclastogenesis.
Julia T Warren +2 more
exaly +5 more sources
RANK Ligand Helps Immunity to Leishmania major by Skewing M2-Like Into M1 Macrophages [PDF]
Frontiers in Immunology, 2020 Macrophages host Leishmania major infection, which causes cutaneous Leishmaniasis in humans. In the murine model, resistance to infection depends on the host immunity mediated by CD4 T-cell cytokines and macrophages.
Thaís S. Rigoni +9 more
doaj +2 more sources
DeepBindPoc: a deep learning method to rank ligand binding pockets using molecular vector representation [PDF]
PeerJ, 2020 Accurate identification of ligand-binding pockets in a protein is important for structure-based drug design. In recent years, several deep learning models were developed to learn important physical–chemical and spatial information to predict ligand ...
Haiping Zhang +6 more
doaj +3 more sources
Histological Regression of Giant Cell Tumor of Bone Following RANK Ligand Inhibition [PDF]
Journal of Investigative Medicine High Impact Case Reports, 2014 Lung metastases are a rare complication of giant cell tumors of bone. We herein describe an interesting case of histological regression and size reduction of lung metastases originating from a primary giant cell tumor of bone in response to the RANK ...
Martin F. Dietrich MD, PhD +3 more
doaj +2 more sources
Autoregulation of RANK ligand in oral squamous cell carcinoma tumor cells [PDF]
Journal of Cellular Physiology, 2018 Yuvaraj Sambandam +2 more
exaly +2 more sources
Inflammation is responsible for systemic bone loss in patients with seropositive rheumatoid arthritis treated with rituximab [PDF]
The Korean Journal of Internal Medicine, 2023 Background/Aims We investigated the effect of rituximab on systemic bone metabolism in patients with seropositive rheumatoid arthritis (RA). Methods Twenty seropositive patients with RA were enrolled and administered one cycle of rituximab.
Mie Jin Lim +3 more
doaj +1 more source
Denosumab use in osteogenesis imperfecta: an update on therapeutic approaches [PDF]
Annals of Pediatric Endocrinology & Metabolism, 2023 Osteogenesis imperfecta (OI) is an inherited skeletal disorder that leads to bone fragility and multiple fractures. Given advances in the genetic understanding of existing phenotypes and newly discovered mutations, therapeutic management of OI has become
Fatma Majdoub +5 more
doaj +1 more source