The effects of chitosan oligosaccharides on OPG and RANKL expression in a rat osteoarthritis model [PDF]
Acta Cirúrgica Brasileira, 2017 Purpose: To investigate the effect of chitosan oligosaccharides (COS) against osteoarthritis (OA) and preliminarily discuss the osteoprotegerin (OPG), receptor activator of NF-κB ligand (RANKL) and RANK expression in a rat OA model.
Chun Zhang +6 more
doaj +1 more source
Receptor activator of NF-kappaB and podocytes: towards a function of a novel receptor-ligand pair in the survival response of podocyte injury. [PDF]
PLoS ONE, 2012 BACKGROUND: Glomerulosclerosis correlates with reduction in podocyte number that occurs through mechanisms which include apoptosis. Podocyte injury or podocyte loss in the renal glomerulus has been proposed as the crucial mechanism in the development of ...
Shuangxin Liu +17 more
doaj +1 more source
Lipopolysaccharide- TLR-4 Axis regulates Osteoclastogenesis independent of RANKL/RANK signaling
BMC Immunology, 2021 Background Lipopolysaccharide (LPS) is an endotoxin and a vital component of gram-negative bacteria’s outer membrane. During gram-negative bacterial sepsis, LPS regulates osteoclast differentiation and activity, in addition to increasing inflammation ...
Mohammed S. AlQranei +4 more
doaj +1 more source
Dysregulated RANK Ligand/RANK Axis in Hyperhomocysteinemic Subjects [PDF]
Stroke, 2009 Background and Purpose— Homocysteine has been linked to increased risk of ischemic stroke and other cardiovascular events. Matrix degradation and inflammation play an important role in these disorders, and we have demonstrated increased levels of matrix-degrading enzymes and inflammatory cytokines in
Marit S, Nenseter +8 more
openaire +2 more sources
Evaluation of the effect of topical and systemic ozone application in periodontitis: an experimental study in rats [PDF]
Journal of Applied Oral Science, 2019 Objective: The goal of the present study was to determine the effect of systemic and topical ozone application on alveolar bone loss (ABL) by evaluating the effect of Hypoxia-inducible factor −1 alpha (HIF-1-α) and receptor activator of NF-kB ligand ...
Ebru Saglam +4 more
doaj +2 more sources
RANK/RANKL/OPG pathway: genetic associations with stress fracture period prevalence in elite athletes [PDF]
, 2015 Context: The RANK/RANKL/OPG signalling pathway is important in the regulation of bone turnover, with single nucleotide polymorphisms (SNPs) in genes within this pathway associated with bone phenotypic adaptations.
Stellingwerff, Trent +13 more
core +1 more source
Boletín Médico del Hospital Infantil de México, 2022 Duchenne muscular dystrophy (DMD) is an X-linked inherited disorder. Patients present with decreased bone mineral density (BMD) due to glucocorticoid therapy and progressive muscle weakness.
Salvador Atilano-Miguel +2 more
doaj +1 more source
Scoring functions and enrichment : a case study on Hsp90 [PDF]
, 2007 This work was funded by the EPSRC, InsightFaraday (now part of the Chemistry Innovation Knowledge Transfer Network), Arrow Therapeutics Ltd and Unilever plc.Background: The need for fast and accurate scoring functions has been driven by the increased use
Chrysi Konstantinou-Kirtay +8 more
core +2 more sources
Ranking ligand affinity for the DNA minor groove by experiment and simulation [PDF]
, 2010 The structural and thermodynamic basis for the strength and selectivity of the interactions of minor-groove binders (MGBs) with DNA is not fully understood.
Supa Hannongbua +25 more
core +1 more source
Disclosing incoherent sparse and low-rank patterns inside homologous GPCR tasks for better modelling of ligand bioactivities [PDF]
, 2021 There are many new and potential drug targets in G protein-coupled receptors (GPCRs) without sufficient ligand associations, and accurately predicting and interpreting ligand bioactivities is vital for screening and optimizing hit compounds targeting ...
Lan, Chuangchuang +7 more
core +1 more source