Results 51 to 60 of about 133,829 (277)
TNF-family member Receptor Activator of NF-$B (RANK) and RANK-Ligand (RANKL) in bone remodelling [PDF]
, 2018 Receptor Activator of NF-κB (RANK) and RANK-Ligand (RANKL) are members of the Tumour Necrosis Factor (TNF)-superfamily involved in bone homeostasis. In a tightly controlled interplay of this receptor and ligand, bone is continuously being remodelled ...
Wang, Yizhou +3 more
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RANK ligand and the regulation of skeletal remodeling [PDF]
Journal of Clinical Investigation, 2003 It has long been known that estrogen deficiency in animal models and postmenopausal women is associated with increased osteoclastic bone resorption and bone loss (1–5). In the past decade, several important discoveries of some of the key factors involved in osteoclast formation, survival, function, and regulation by estrogen have been made. A number
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Eribulin mesylate induces bone mass loss by promoting osteoclastic bone resorption in mice
Bone Reports, 2023 Over the past few decades, the clinical outcomes of patients with cancer have significantly improved mostly owing to the development of effective chemotherapeutic treatments. However, chronic health conditions such as bone mass loss and risk of fragility
Takahiro Ishizaka +12 more
doaj +1 more source
Einfluss des RANK-Ligand Inhibitors Denosumab auf H3F3A-mutierte Riesenzelltumoren in situ und in vitro [PDF]
, 2023 Die vorliegende Arbeit untersuchte einen Zusammenhang zwischen dem Riesenzelltumor des Knochens und den unter Denosumabtherapie beschriebenen Sarkomen.
Hasenfratz, Marc
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Statistical Potential for Modeling and Ranking of Protein–Ligand Interactions [PDF]
Journal of Chemical Information and Modeling, 2011 Applications in structural biology and medicinal chemistry require protein-ligand scoring functions for two distinct tasks: (i) ranking different poses of a small molecule in a protein binding site and (ii) ranking different small molecules by their complementarity to a protein site.
Hao Fan 0002 +5 more
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Receptor activator of NF-kB (RANK) and RANK ligand protein expression in invasive ductal carcinoma. [PDF]
, 2009 Abstract #2057 Purpose: Bone metastases are commonly observed in patients with advanced breast cancer. Tumor cells interact with the bone microenvironment to induce osteoclastogenesis via local bone stromal expression of receptor activator
A Jacob +9 more
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AtomNet PoseRanker: Enriching Ligand Pose Quality for Dynamic Proteins in Virtual High Throughput Screens [PDF]
, 2021 Structure-based, virtual High Throughput Screening (vHTS) methods for predicting ligand activity in drug discovery are important when there are no or relatively few known compounds that interact with a therapeutic target of interest.
Kate, Stafford +3 more
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Nature Communications, 2020 Receptor activator of nuclear factor-κB (RANK)/RANK-ligand (RANKL) signaling regulates the tumor-immune crosstalk. Here the authors show that systemic RANKL inhibition promotes CD8 + T cell infiltration in patients with early breast cancer and that loss ...
Clara Gómez-Aleza +33 more
doaj +1 more source
Frontiers in Genetics, 2021 Osteoclasts are the sole bone resorbing cells, which undertake opposing roles to osteoblasts to affect skeletal mass and structure. However, unraveling the comprehensive molecular mechanisms behind osteoclast differentiation is necessitated to overcome ...
Salman M. Toor +3 more
doaj +1 more source
Rapid rescoring and refinement of ligand-receptor complexes using REMD with a MC pose reservoir [PDF]
, 2023 Virtual screening (VS) involves generation of poses for a library of ligands, and ranking using simplified energy functions and limited flexibility. Top scored poses are used to rank and prioritize ligands.
Kelley, Chiu +4 more
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