Results 51 to 60 of about 1,084,074 (266)

Inhibition of choroidal osteoma progression using bisphosphonate and RANKL-inhibitory treatment

American Journal of Ophthalmology Case Reports
Purpose: To describe the use of anti-osteoclastic medications (i.e., bisphosphonates and receptor activator of nuclear factor kappa beta (RANK) ligand inhibitors) in treating choroidal osteoma.
Mélanie Hébert, Kelly Babic, Edward C. Hsiao, Armin Afshar, Nisha Acharya, John A. Gonzales   +5 more
doaj   +1 more source

Clinical, instrumental, serological and histological findings suggest that hemophilia B may be less severe than hemophilia A

Haematologica, 2016
Recent evidence suggests that patients with severe hemophilia B may have a less severe disease compared to severe hemophilia A. To investigate clinical, radiological, laboratory and histological differences in the arthropathy of severe hemophilia A and ...
Daniela Melchiorre, Silvia Linari, Mirko Manetti, Eloisa Romano, Francesco Sofi, Marco Matucci-Cerinic, Christian Carulli, Massimo Innocenti, Lidia Ibba-Manneschi, Giancarlo Castaman   +9 more
doaj   +1 more source

Soluble rank ligand produced by myeloma cells causes generalised bone loss in multiple myeloma. [PDF]

PLoS ONE, 2012
Patients with multiple myeloma commonly develop focal osteolytic bone disease, as well as generalised osteoporosis. The mechanisms underlying the development of osteoporosis in patients with myeloma are poorly understood. Although disruption of the RANKL/
Clive Henry Buckle, Evy De Leenheer, Michelle Anne Lawson, Kwee Yong, Neil Rabin, Mark Perry, Karen Vanderkerken, Peter Ian Croucher   +7 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Osteoporose e erosões osseas focais na artrite reumatóide: da patogênese ao tratamento Osteoporosis and focal erosive bone lesions in rheumatoid arthritis: pathogeny and treatment

Revista Brasileira de Reumatologia, 2004
As erosões ósseas focais e a osteoporose constituem manifestações características da artrite reumatóide e são importantes no desenvolvimento de deformidades e incapacidade funcional relacionadas com a doença.
Ivânio Alves Pereira, Rosa Maria Rodrigues Pereira   +1 more
doaj   +1 more source

Angiotensin II Induces Aortic Rupture and Dissection in Osteoprotegerin‐Deficient Mice

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background The biological mechanism of action for osteoprotegerin, a soluble decoy receptor for the receptor activator of nuclear factor‐kappa B ligand in the vascular structure, has not been elucidated.
Toshihiro Tsuruda, Atsushi Yamashita, Misa Otsu, Masanori Koide, Yuko Nakamichi, Yoko Sekita‐Hatakeyama, Kinta Hatakeyama, Taro Funamoto, Etsuo Chosa, Yujiro Asada, Nobuyuki Udagawa, Johji Kato, Kazuo Kitamura   +12 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Receptor Activator of Nuclear Factor-Kappa Ligand and Osteoprotegerin Expressions on Hyperglycemic Wistar Rats (Rattus Novergicus) During Orthodontic Tooth Movement

Pesquisa Brasileira em Odontopediatria e Clínica Integrada, 2022
Objective: To investigate the differences of receptor activator of nuclear factor-κB ligand (RANKL) and Osteoprotegerin (OPG) expressions between normoglycemic and hyperglycemic Wistar rats (Rattus Novergicus) during Orthodontic Tooth Movement (OTM ...
Alida Alida, Ervina Restiwulan Winoto, Ida Bagus Narmada   +2 more
doaj  

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Effect of Lovastatin on Serum Osteoprotegerin Level in Type 2 Diabetic Nephropathy

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2012
BACKGROUND AND OBJECTIVE: Osteoprotegerin (OPG), a glycoprotein is a member of the tumor necrotizing factor alpha receptor super-family. By considering the possible role of OPG in cardiovascular disease (CVD), higher incidence of CVD in patients with ...
N Nezami,, M Asghari, J Safa, MM Bagheri Asl, B Salari, S Ghorashi   +5 more
doaj