Results 71 to 80 of about 1,084,074 (266)

$p$-groups with maximal elementary abelian subgroups of rank $2$ [PDF]

, 2010
Let p be an odd prime number and G a finite p-group. We prove that if the rank of G is greater than p, then G has no maximal elementary abelian subgroup of rank 2.
Mazza, Nadia, Glauberman, George
core   +4 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

MoMA-LigPath: A web server to simulate protein-ligand unbinding [PDF]

, 2013
Protein-ligand interactions taking place far away from the active site, during ligand binding or release, may determine molecular specificity and activity. However, obtaining information about these interactions with experimental or computational methods
Al Bluwi, Ibrahim, Devaurs, Didier, Vaisset, Marc, Iehl, Romain, Bouard, Léa, Al-Bluwi, Ibrahim, Siméon, Thierry, Cortés, Juan, Zanon, Christophe   +8 more
core   +1 more source

FUSING SIMILARITY RANKINGS IN LIGAND-BASED VIRTUAL SCREENING [PDF]

Computational and Structural Biotechnology Journal, 2013
Data fusion is the name given to a range of methods for combining multiple sources of evidence. This mini-review summarizes the use of one such class of methods for combining the rankings obtained when similarity searching is used for ligand-based virtual screening.
openaire   +5 more sources

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Effects of orthodontic tooth movement on periodontal tissues after ligature-induced periodontitis through the mechanism of RANKL-induced osteoclastogenesis: an animal study

BMC Oral Health
Background In recent years, there has been a growing interest in adult orthodontics due to increasing aesthetic demands and advancements in treatment modalities. As more adults seek orthodontic treatment, clinicians frequently encounter patients with pre-
Buse Basak Feyizoglu, Batuhan Hazar Aysesek, Suheyla Kaya, Ulku Baser, Vakur Olgac, Aysen Gulden Isik   +5 more
doaj   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Rank of divisors on tropical curves [PDF]

, 2013
We investigate, using purely combinatorial methods, structural and algorithmic properties of linear equivalence classes of divisors on tropical curves.
Králʼ, Daniel, Hladký, Jan, Norine, Serguei   +2 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

RANKL/RANK signaling recruits Tregs via the CCL20–CCR6 pathway and promotes stemness and metastasis in colorectal cancer

Cell Death and Disease
TNF receptor superfamily member 11a (TNFRSF11a, RANK) and its ligand TNF superfamily member 11 (TNFRSF11, RANKL) are overexpressed in many malignancies. However, the clinical importance of RANKL/RANK in colorectal cancer (CRC) is mainly unknown.
Jing Ouyang, Shuang Hu, Qingqing Zhu, Chenxin Li, Tingting Kang, Wenlin Xie, Yun Wang, Yan Li, Yingsi Lu, Junhua Qi, Ming Xia, Jinrun Chen, Yingqian Yang, Yazhou Sun, Tianshun Gao, Liping Ye, Qian Liang, Yihang Pan, Chengming Zhu   +18 more
doaj   +1 more source