Results 91 to 100 of about 133,829 (277)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Το σύστημα RANK, RANK-L και οστεοπροτεγερίνης ως βιοδείκτης [PDF]

, 2022
Το σύστημα του συνδέτη του ενεργοποιητή του υποδοχέα του πυρηνικού παράγοντα κΒ (RANK-L), του ενεργοποιητή του υποδοχέα του πυρηνικού παράγοντα κΒ (RANK) και της οστεοπροτεγερίνης (OPG) αναγνωρίστηκε στα τέλη της δεκαετίας του 1990, στην προσπάθεια ...
Chaliasou Anna-Louiza, Χαλιάσου Άννα-Λουίζα   +1 more
core  

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Molecular Triad RANK/ RANKL/ OPG in Mandible and Femur of Wistar Rats (Rattus norvegicus) With Type 2 Diabetes Mellitus [PDF]

, 2019
A successful treatment of dental implant needs a good jaw bone support, which depends on healthy bone metabolism. Bone metabolism can be affected by Diabetes Mellitus (DM). It may trigger various complications, including osteoporosis.
Primarinda D. Hapsari, Rostiny, Abil Kurdi, Ratri Maya Sitalaksmi, Muhammad D.A. Ari, Nike Hendrijantini, Puthi Y.I. Sati, Valentina V. Arief   +7 more
core   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Rank-ordering protein-ligand binding affinity by a quantum mechanics/molecular mechanics/Poisson-Boltzmann-surface area model [PDF]

, 2007
The authors describe a quantum mechanics/molecular mechanics/Poisson-Boltzmann-surface area model for rank-ordering protein-ligand binding affinity in aqueous solution.
Mingliang Wang, Wang, Mingliang, Wong, Chung, Chung F. Wong   +3 more
core   +2 more sources

Impact of denosumab on fracture healing in osteoporotic patients: A double-blind, randomized trial [PDF]

Journal of Krishna Institute of Medical Sciences University
Background: Osteoporosis delays fracture healing due to impaired bone remodeling. Denosumab, a monoclonal antibody targeting RANKL, reduces fracture risk but its role in healing is underexplored. Aim and Objectives: To evaluate the effect of denosumab on
Smit D. Upadhyay, Sameer Haveri
doaj  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Osteoprotegerin (OPG) and receptor activator of NF-kB ligand (RANK-L) serum levels in patients on chronic hemodialysis [PDF]

, 2005
The mechanisms underlying the skeletal resistance to PTH in patients on chronic hemodialysis (CHD) are not yet fully clarified. Osteoprotegerin (OPG) and receptor activator of NF-kB ligand (RANK-L) modulate the genesis and activity of osteoclasts ...
Cadirni A., Montagnani A., Gaggiotti E., Caffarelli C., Franci M. B., Lucani B., Gonnelli S., Campagna M. S., Nuti R.   +8 more
core   +1 more source