Results 101 to 110 of about 133,829 (277)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
BMC Oral HealthBackground In recent years, there has been a growing interest in adult orthodontics due to increasing aesthetic demands and advancements in treatment modalities. As more adults seek orthodontic treatment, clinicians frequently encounter patients with pre-
Buse Basak Feyizoglu +5 more
doaj +1 more source
FEBS Letters, EarlyView.Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley +1 more source
Cell Death and DiseaseTNF receptor superfamily member 11a (TNFRSF11a, RANK) and its ligand TNF superfamily member 11 (TNFRSF11, RANKL) are overexpressed in many malignancies. However, the clinical importance of RANKL/RANK in colorectal cancer (CRC) is mainly unknown.
Jing Ouyang +18 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
The Role of Myeloma Cells to Osteoclast Activation [PDF]
Cell Journal, 2010 Objective: Multiple myeloma (MM) is a hematological malignancy characterized by osteolyticbone disease which is associated with severe bone pain and pathological bonefractures.
Bahare Sadeghi +5 more
doaj
Denosumab for the treatment of bone metastases in breast cancer: evidence and opinion
Therapeutic Advances in Medical Oncology, 2011 Introduction: Denosumab, a fully human monoclonal antibody, targets the receptor activator of nuclear factor-kappaB (RANK) ligand, a protein essential for osteoclast differentiation, activity and survival.
Guenther G. Steger, Rupert Bartsch
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Soluble TRAIL enhanced bone destruction acting on Rank-ligand in estrogen dependent/independent human brest cancer cell lines. [PDF]
, 2008 Soluble TRAIL enhanced bone destruction acting on Rank-ligand in estrogen dependent/independent human brest cancer cell ...
NICOLIN, VANESSA, NARDUCCI, PAOLA
core
Evaluation of the osteoclastogenic process associated with RANK / RANK-L / OPG in odontogenic myxomas [PDF]
, 2018 Odontogenic myxoma (OM) is a benign intraosseous neoplasm that exhibits local aggressiveness and high recurrence rates. Osteoclastogenesis is an important phenomenon in the tumor growth of maxillary neoplasms.
Gonzalez Galvan, Maria del Carmen +13 more
core +1 more source