Results 31 to 40 of about 1,142,931 (269)

Dysregulated RANK Ligand/RANK Axis in Hyperhomocysteinemic Subjects [PDF]

Stroke, 2009
Background and Purpose— Homocysteine has been linked to increased risk of ischemic stroke and other cardiovascular events. Matrix degradation and inflammation play an important role in these disorders, and we have demonstrated increased levels of matrix-degrading enzymes and inflammatory cytokines in
Marit S, Nenseter, Thor, Ueland, Kjetil, Retterstøl, Ellen, Strøm, Lars, Mørkrid, Sverre, Landaas, Leiv, Ose, Pål, Aukrust, Kirsten B, Holven   +8 more
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RANK ligand and the regulation of skeletal remodeling [PDF]

Journal of Clinical Investigation, 2003
It has long been known that estrogen deficiency in animal models and postmenopausal women is associated with increased osteoclastic bone resorption and bone loss (1–5). In the past decade, several important discoveries of some of the key factors involved in osteoclast formation, survival, function, and regulation by estrogen have been made. A number
openaire   +2 more sources

Ranking ligand affinity for the DNA minor groove by experiment and simulation [PDF]

, 2010
The structural and thermodynamic basis for the strength and selectivity of the interactions of minor-groove binders (MGBs) with DNA is not fully understood.
Wittayanarakul, Kitiyaporn, Parkinson, John A, Hannongbua, Supa, Anthony, Nahoum G., Treesuwan, Witcha, Suckling, Colin J., Khalaf, Abedawn I., Alniss, Hasan, Mackay, Simon P.   +8 more
core   +3 more sources

Eribulin mesylate induces bone mass loss by promoting osteoclastic bone resorption in mice

Bone Reports, 2023
Over the past few decades, the clinical outcomes of patients with cancer have significantly improved mostly owing to the development of effective chemotherapeutic treatments. However, chronic health conditions such as bone mass loss and risk of fragility
Takahiro Ishizaka, Keisuke Horiuchi, Shinya Kondo, Masashi Isaji, Takahiro Nakagawa, Masahiro Inoue, Hajime Rikitake, Eiko Taguchi, Michiro Susa, Masaki Yoda, Takeshi Ono, Yusuke Kozai, Kazuhiro Chiba   +12 more
doaj   +1 more source

Scoring functions and enrichment : a case study on Hsp90 [PDF]

, 2007
This work was funded by the EPSRC, InsightFaraday (now part of the Chemistry Innovation Knowledge Transfer Network), Arrow Therapeutics Ltd and Unilever plc.Background: The need for fast and accurate scoring functions has been driven by the increased use
Chrysi Konstantinou-Kirtay, Lumley James A, Konstantinou-Kirtay, Chrysi, John BO Mitchell, James A Lumley, Lumley, James A., Mitchell John BO, Mitchell, John Blayney Owen, Konstantinou-Kirtay Chrysi, Mitchell, John Blayney Owen; id_orcid   +9 more
core   +3 more sources

RANK Ligand and Osteoprotegerin [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2002
In 1997, investigators isolated a secreted glycoprotein that blocked osteoclast differentiation from precursor cells, prevented osteoporosis (decreased bone mass) when administered to ovariectomized rats, and resulted in osteopetrosis (increased bone mass) when overexpressed in transgenic mice.
Michael, Schoppet, Klaus T, Preissner, Lorenz C, Hofbauer   +2 more
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Inhibition of RANK signaling in breast cancer induces an anti-tumor immune response orchestrated by CD8+ T cells

Nature Communications, 2020
Receptor activator of nuclear factor-κB (RANK)/RANK-ligand (RANKL) signaling regulates the tumor-immune crosstalk. Here the authors show that systemic RANKL inhibition promotes CD8 + T cell infiltration in patients with early breast cancer and that loss ...
Clara Gómez-Aleza, Bastien Nguyen, Guillermo Yoldi, Marina Ciscar, Alexandra Barranco, Enrique Hernández-Jiménez, Marion Maetens, Roberto Salgado, Maria Zafeiroglou, Pasquale Pellegrini, David Venet, Soizic Garaud, Eva M. Trinidad, Sandra Benítez, Peter Vuylsteke, Laura Polastro, Hans Wildiers, Philippe Simon, Geoffrey Lindeman, Denis Larsimont, Gert Van den Eynden, Chloé Velghe, Françoise Rothé, Karen Willard-Gallo, Stefan Michiels, Purificación Muñoz, Thierry Walzer, Lourdes Planelles, Josef Penninger, Hatem A. Azim, Sherene Loi, Martine Piccart, Christos Sotiriou, Eva González-Suárez   +33 more
doaj   +1 more source

Comprehensive Transcriptomic Profiling of Murine Osteoclast Differentiation Reveals Novel Differentially Expressed Genes and LncRNAs

Frontiers in Genetics, 2021
Osteoclasts are the sole bone resorbing cells, which undertake opposing roles to osteoblasts to affect skeletal mass and structure. However, unraveling the comprehensive molecular mechanisms behind osteoclast differentiation is necessitated to overcome ...
Salman M. Toor, Sachin Wani, Omar M. E. Albagha, Omar M. E. Albagha   +3 more
doaj   +1 more source

RANK and RANKL Expression in Salivary Gland Tumors

Ear, Nose & Throat Journal, 2020
Objectives: The pathogenesis and molecular basis of salivary gland tumors (SGT) are not well understood. We investigated the expression of receptor activator of nuclear factor κB (RANK) and RANK ligand (RANKL) in benign and malignant SGTs and their ...
Figen Aslan MD, Ülkü Küçük MD
doaj   +1 more source

Statistical Potential for Modeling and Ranking of Protein–Ligand Interactions [PDF]

Journal of Chemical Information and Modeling, 2011
Applications in structural biology and medicinal chemistry require protein-ligand scoring functions for two distinct tasks: (i) ranking different poses of a small molecule in a protein binding site and (ii) ranking different small molecules by their complementarity to a protein site.
Hao Fan 0002, Dina Schneidman-Duhovny, John J. Irwin, Guang Qiang Dong, Brian K. Shoichet, Andrej Sali   +5 more
openaire   +3 more sources