Results 31 to 40 of about 1,084,074 (266)
Boletín Médico del Hospital Infantil de México, 2022 Duchenne muscular dystrophy (DMD) is an X-linked inherited disorder. Patients present with decreased bone mineral density (BMD) due to glucocorticoid therapy and progressive muscle weakness.
Salvador Atilano-Miguel +2 more
doaj +1 more source
Dysregulated RANK Ligand/RANK Axis in Hyperhomocysteinemic Subjects [PDF]
Stroke, 2009 Background and Purpose— Homocysteine has been linked to increased risk of ischemic stroke and other cardiovascular events. Matrix degradation and inflammation play an important role in these disorders, and we have demonstrated increased levels of matrix-degrading enzymes and inflammatory cytokines in
Marit S, Nenseter +8 more
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RANK ligand and the regulation of skeletal remodeling [PDF]
Journal of Clinical Investigation, 2003 It has long been known that estrogen deficiency in animal models and postmenopausal women is associated with increased osteoclastic bone resorption and bone loss (1–5). In the past decade, several important discoveries of some of the key factors involved in osteoclast formation, survival, function, and regulation by estrogen have been made. A number
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Eribulin mesylate induces bone mass loss by promoting osteoclastic bone resorption in mice
Bone Reports, 2023 Over the past few decades, the clinical outcomes of patients with cancer have significantly improved mostly owing to the development of effective chemotherapeutic treatments. However, chronic health conditions such as bone mass loss and risk of fragility
Takahiro Ishizaka +12 more
doaj +1 more source
RANK Ligand and Osteoprotegerin [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2002 In 1997, investigators isolated a secreted glycoprotein that blocked osteoclast differentiation from precursor cells, prevented osteoporosis (decreased bone mass) when administered to ovariectomized rats, and resulted in osteopetrosis (increased bone mass) when overexpressed in transgenic mice.
Michael, Schoppet +2 more
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Nature Communications, 2020 Receptor activator of nuclear factor-κB (RANK)/RANK-ligand (RANKL) signaling regulates the tumor-immune crosstalk. Here the authors show that systemic RANKL inhibition promotes CD8 + T cell infiltration in patients with early breast cancer and that loss ...
Clara Gómez-Aleza +33 more
doaj +1 more source
Frontiers in Genetics, 2021 Osteoclasts are the sole bone resorbing cells, which undertake opposing roles to osteoblasts to affect skeletal mass and structure. However, unraveling the comprehensive molecular mechanisms behind osteoclast differentiation is necessitated to overcome ...
Salman M. Toor +3 more
doaj +1 more source
RANK and RANKL Expression in Salivary Gland Tumors
Ear, Nose & Throat Journal, 2020 Objectives: The pathogenesis and molecular basis of salivary gland tumors (SGT) are not well understood. We investigated the expression of receptor activator of nuclear factor κB (RANK) and RANK ligand (RANKL) in benign and malignant SGTs and their ...
Figen Aslan MD, Ülkü Küçük MD
doaj +1 more source
Statistical Potential for Modeling and Ranking of Protein–Ligand Interactions [PDF]
Journal of Chemical Information and Modeling, 2011 Applications in structural biology and medicinal chemistry require protein-ligand scoring functions for two distinct tasks: (i) ranking different poses of a small molecule in a protein binding site and (ii) ranking different small molecules by their complementarity to a protein site.
Hao Fan 0002 +5 more
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Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source