Self-Assembled RANK Induces Osteoclastogenesis Ligand-Independently
Journal of Bone and Mineral Research, 2005 Abstract By immunoprecipitation assay, we showed that mouse RANK was self-assembled through its cytoplasmic domain located at position 534–539, whose domain was different form TRAF binding domains. Moreover, overexpression experiments showed that oligomeric RANK, which was self-associated, induced osteoclastogenesis ligand-independently.
Akira Kudo
exaly +3 more sources
Inflammation is responsible for systemic bone loss in patients with seropositive rheumatoid arthritis treated with rituximab [PDF]
The Korean Journal of Internal Medicine, 2023 Background/Aims We investigated the effect of rituximab on systemic bone metabolism in patients with seropositive rheumatoid arthritis (RA). Methods Twenty seropositive patients with RA were enrolled and administered one cycle of rituximab.
Mie Jin Lim +3 more
doaj +1 more source
Denosumab use in osteogenesis imperfecta: an update on therapeutic approaches [PDF]
Annals of Pediatric Endocrinology & Metabolism, 2023 Osteogenesis imperfecta (OI) is an inherited skeletal disorder that leads to bone fragility and multiple fractures. Given advances in the genetic understanding of existing phenotypes and newly discovered mutations, therapeutic management of OI has become
Fatma Majdoub +5 more
doaj +1 more source
Discontinuing Denosumab: Can It Be Done Safely? A Review of the Literature [PDF]
Endocrinology and Metabolism, 2022 Denosumab, which has been approved for the treatment of osteoporosis since 2010, is a fully humanised monoclonal antibody against a cytokine, receptor activator of nuclear factor kappa B ligand (RANKL), involved in bone resorption.
Wei Lin Tay, Donovan Tay
doaj +1 more source
Tocotrienol regulates osteoclastogenesis in rheumatoid arthritis [PDF]
The Korean Journal of Internal Medicine, 2021 Background/Aims The present study aimed to investigate whether tocotrienol regulates interleukin 17 (IL-17)-induced osteoclastogenesis in rheumatoid arthritis (RA).
Kyoung-Woon Kim +6 more
doaj +1 more source
NIP45 negatively regulates RANK ligand induced osteoclast differentiation [PDF]
Journal of Cellular Biochemistry, 2012 Shanmugarajan S +3 more
exaly +2 more sources
N-acetyl-l-cysteine controls osteoclastogenesis through regulating Th17 differentiation and RANKL in rheumatoid arthritis [PDF]
The Korean Journal of Internal Medicine, 2019 Background/Aims This study aimed to determine the regulatory role of N-acetyl-l-cysteine (NAC), an antioxidant, in interleukin 17 (IL-17)-induced osteoclast differentiation in rheumatoid arthritis (RA).
Hae-Rim Kim +4 more
doaj +1 more source
Implicating Receptor Activator of NF-κB (RANK)/RANK Ligand Signalling in Microglial Responses to Toll-Like Receptor Stimuli. [PDF]
Dev Neurosci, 2017 Inflammation in the perinatal brain caused by maternal or intrauterine fetal infection is now well established as an important contributor to the development of perinatal brain injury.
Kichev A +4 more
europepmc +2 more sources
The role of RANK ligand/OPG system in bone erosions in rheumatoid arthritis [PDF]
Arthritis Res Ther, 2012 There is still growing insight on the links between the immune system and bone at the anatomical, vascular, cellular and molecular level. A the anatomical level, bone is at the inside in direct contact with the bone marrow and at the outside with ...
Geusens P.
europepmc +2 more sources
RANK Signaling in the Differentiation and Regeneration of Thymic Epithelial Cells [PDF]
, 2021 International audienceThymic epithelial cells (TECs) provide essential clues for the proliferation, survival, migration, and differentiation of thymocytes.
Irla, Magali
core +1 more source