Results 31 to 40 of about 208,218 (280)
GibbsCluster: unsupervised clustering and alignment of peptide sequences [PDF]
, 2017 Receptor interactions with short linear peptide fragments (ligands) are at the base of many biological signaling processes. Conserved and information-rich amino acid patterns, commonly called sequence motifs, shape and regulate these interactions ...
Alvarez, Bruno +2 more
core +2 more sources
RANK Ligand and Osteoprotegerin [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2002 In 1997, investigators isolated a secreted glycoprotein that blocked osteoclast differentiation from precursor cells, prevented osteoporosis (decreased bone mass) when administered to ovariectomized rats, and resulted in osteopetrosis (increased bone mass) when overexpressed in transgenic mice.
Michael, Schoppet +2 more
openaire +2 more sources
Eribulin mesylate induces bone mass loss by promoting osteoclastic bone resorption in mice
Bone Reports, 2023 Over the past few decades, the clinical outcomes of patients with cancer have significantly improved mostly owing to the development of effective chemotherapeutic treatments. However, chronic health conditions such as bone mass loss and risk of fragility
Takahiro Ishizaka +12 more
doaj +1 more source
Expression of TIM3/VISTA checkpoints and the CD68 macrophage-associated marker correlates with anti-PD1/PDL1 resistance: implications of immunogram heterogeneity. [PDF]
, 2020 Although immunotherapies have achieved remarkable salutary effects among subgroups of advanced cancers, most patients do not respond. We comprehensively evaluated biomarkers associated with the "cancer-immunity cycle" in the pan-cancer setting in order ...
Dressman, Devin +13 more
core +1 more source
RANK ligand and the regulation of skeletal remodeling [PDF]
Journal of Clinical Investigation, 2003 It has long been known that estrogen deficiency in animal models and postmenopausal women is associated with increased osteoclastic bone resorption and bone loss (1–5). In the past decade, several important discoveries of some of the key factors involved in osteoclast formation, survival, function, and regulation by estrogen have been made. A number
openaire +2 more sources
Similarity-based virtual screening using 2D fingerprints [PDF]
, 2006 This paper summarises recent work at the University of Sheffield on virtual screening methods that use 2D fingerprint measures of structural similarity. A detailed comparison of a large number of similarity coefficients demonstrates that the well-known ...
Willett, P.
core +1 more source
Positioning novel biologicals in CKD-mineral and bone disorders [PDF]
, 2017 Renal osteodystrophy (ROD), the histologic bone lesions of chronic kidney disease (CKD), is now included in a wider syndrome with laboratory abnormalities of mineral metabolism and extra-skeletal calcifications or CKD-mineral and bone disorders (CKD-MBD),
Covic, Adrian +5 more
core +1 more source
Frontiers in Genetics, 2021 Osteoclasts are the sole bone resorbing cells, which undertake opposing roles to osteoblasts to affect skeletal mass and structure. However, unraveling the comprehensive molecular mechanisms behind osteoclast differentiation is necessitated to overcome ...
Salman M. Toor +3 more
doaj +1 more source
The role of RANK-ligand inhibition in cancer: the story of denosumab. [PDF]
Oncologist, 2011 Abstract The diagnosis of bone metastases is an event with certain consequences for the patient. They often mean pain and can also mean pathological fractures, hypercalcemia, and spinal cord compression, all synonymous with a diminished quality of life and often also hospitalization.
Castellano D +5 more
europepmc +4 more sources
Activated γδ T cells inhibit osteoclast differentiation and resorptive activity in vitro [PDF]
, 2013 Peer reviewedPublisher ...
Pappalardo, A., Thompson, K.
core +1 more source