Results 21 to 30 of about 133,829 (277)
Bone metastasis in breast cancer: The story of RANK-Ligand [PDF]
Journal of the Egyptian National Cancer Institute, 2012 The primary cellular mechanism responsible for osteolytic bone metastases is osteoclastic activation. Preclinical models have shown that breast cancer cells can produce parathyroid hormone-related protein (PTHrP), and other osteolytic molecules, which stimulate excessive osteoclastic bone resorption and establishment of osteolytic lesions.
exaly +4 more sources
Rank ligand as a target in musculoskeletal neoplasms. [PDF]
Curr Rev Musculoskelet Med, 2015 Receptor activator of nuclear factor-κB ligand (RANKL) is a tumor necrosis factor (TNF) family member, which signals through the osteoclast surface RANK. As such, RANKL is required for osteoclast differentiation and function, namely bone resorption. There is now growing evidence that RANKL is a therapeutic target for musculoskeletal neoplasms, namely ...
Cote GM.
europepmc +4 more sources
RANK Ligand Helps Immunity to Leishmania major by Skewing M2-Like Into M1 Macrophages [PDF]
Frontiers in Immunology, 2020 Macrophages host Leishmania major infection, which causes cutaneous Leishmaniasis in humans. In the murine model, resistance to infection depends on the host immunity mediated by CD4 T-cell cytokines and macrophages.
Thaís S. Rigoni +9 more
doaj +2 more sources
Breast Cancer: Rank Ligand Inhibition. [PDF]
Breast Care (Basel), 2010 Breast cancer and bone health are closely linked. Early menopause induced by gonadotropin-releasing hormone analogues or chemotherapy as well as aromatase inhibitors reduce oestrogen levels, thereby causing cancer treatment-induced bone loss (CTIBL). Furthermore, bone metastases are commonly found in advanced disease. Current treatment options for bone
Bartsch R +3 more
europepmc +4 more sources
RANK Ligand and Osteoprotegerin [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2002 In 1997, investigators isolated a secreted glycoprotein that blocked osteoclast differentiation from precursor cells, prevented osteoporosis (decreased bone mass) when administered to ovariectomized rats, and resulted in osteopetrosis (increased bone mass) when overexpressed in transgenic mice.
Michael, Schoppet +2 more
openaire +4 more sources
Dysregulated Osteoprotegerin/RANK Ligand/RANK Axis in Clinical and Experimental Heart Failure [PDF]
Circulation, 2005 Background— Persistent inflammation appears to play a role in the development of heart failure (HF). Osteoprotegerin (OPG), the receptor activator of nuclear factor-κB (RANK), and RANK ligand (RANKL) are newly discovered members of the tumor necrosis factor superfamily that are critical regulators in
Thor Ueland +2 more
exaly +3 more sources
RANK and RANKL Expression in Salivary Gland Tumors [PDF]
Ear, Nose & Throat Journal, 2020 Objectives: The pathogenesis and molecular basis of salivary gland tumors (SGT) are not well understood. We investigated the expression of receptor activator of nuclear factor κB (RANK) and RANK ligand (RANKL) in benign and malignant SGTs and their ...
Figen Aslan MD, Ülkü Küçük MD
doaj +2 more sources
The role of RANK-ligand inhibition in cancer: the story of denosumab. [PDF]
Oncologist, 2011 Abstract The diagnosis of bone metastases is an event with certain consequences for the patient. They often mean pain and can also mean pathological fractures, hypercalcemia, and spinal cord compression, all synonymous with a diminished quality of life and often also hospitalization.
Castellano D +5 more
europepmc +4 more sources
The role of rank-ligand inhibition in the treatment of postmenopausal osteoporosis
Reumatismo, 2011 Osteoporosis is a skeletal disease affecting millions of people worldwide in which a decreased bone mass and a microarchitectural deterioration compromise bone strength leading to bone fragility and increased susceptibility to fracture.
M. Varenna, D. Gatti
doaj +6 more sources
Autoregulation of RANK ligand in oral squamous cell carcinoma tumor cells [PDF]
Journal of Cellular Physiology, 2018 Chad Novince +2 more
exaly +2 more sources