Results 21 to 30 of about 127,342 (255)
Lipopolysaccharide- TLR-4 Axis regulates Osteoclastogenesis independent of RANKL/RANK signaling
BMC Immunology, 2021 Background Lipopolysaccharide (LPS) is an endotoxin and a vital component of gram-negative bacteria’s outer membrane. During gram-negative bacterial sepsis, LPS regulates osteoclast differentiation and activity, in addition to increasing inflammation ...
Mohammed S. AlQranei +4 more
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Dysregulated RANK Ligand/RANK Axis in Hyperhomocysteinemic Subjects [PDF]
Stroke, 2009 Background and Purpose— Homocysteine has been linked to increased risk of ischemic stroke and other cardiovascular events. Matrix degradation and inflammation play an important role in these disorders, and we have demonstrated increased levels of matrix-degrading enzymes and inflammatory cytokines in
Marit S, Nenseter +8 more
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Evaluation of the effect of topical and systemic ozone application in periodontitis: an experimental study in rats [PDF]
Journal of Applied Oral Science, 2019 Objective: The goal of the present study was to determine the effect of systemic and topical ozone application on alveolar bone loss (ABL) by evaluating the effect of Hypoxia-inducible factor −1 alpha (HIF-1-α) and receptor activator of NF-kB ligand ...
Ebru Saglam +4 more
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Boletín Médico del Hospital Infantil de México, 2022 Duchenne muscular dystrophy (DMD) is an X-linked inherited disorder. Patients present with decreased bone mineral density (BMD) due to glucocorticoid therapy and progressive muscle weakness.
Salvador Atilano-Miguel +2 more
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RANK Ligand and Osteoprotegerin [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2002 In 1997, investigators isolated a secreted glycoprotein that blocked osteoclast differentiation from precursor cells, prevented osteoporosis (decreased bone mass) when administered to ovariectomized rats, and resulted in osteopetrosis (increased bone mass) when overexpressed in transgenic mice.
Michael, Schoppet +2 more
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Eribulin mesylate induces bone mass loss by promoting osteoclastic bone resorption in mice
Bone Reports, 2023 Over the past few decades, the clinical outcomes of patients with cancer have significantly improved mostly owing to the development of effective chemotherapeutic treatments. However, chronic health conditions such as bone mass loss and risk of fragility
Takahiro Ishizaka +12 more
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Frontiers in Genetics, 2021 Osteoclasts are the sole bone resorbing cells, which undertake opposing roles to osteoblasts to affect skeletal mass and structure. However, unraveling the comprehensive molecular mechanisms behind osteoclast differentiation is necessitated to overcome ...
Salman M. Toor +3 more
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Self-Assembled RANK Induces Osteoclastogenesis Ligand-Independently
Journal of Bone and Mineral Research, 2005 Abstract By immunoprecipitation assay, we showed that mouse RANK was self-assembled through its cytoplasmic domain located at position 534–539, whose domain was different form TRAF binding domains. Moreover, overexpression experiments showed that oligomeric RANK, which was self-associated, induced osteoclastogenesis ligand-independently.
Kanazawa, K., Kudo, A.
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Nature Communications, 2020 Receptor activator of nuclear factor-κB (RANK)/RANK-ligand (RANKL) signaling regulates the tumor-immune crosstalk. Here the authors show that systemic RANKL inhibition promotes CD8 + T cell infiltration in patients with early breast cancer and that loss ...
Clara Gómez-Aleza +33 more
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RANK and RANKL Expression in Salivary Gland Tumors
Ear, Nose & Throat Journal, 2020 Objectives: The pathogenesis and molecular basis of salivary gland tumors (SGT) are not well understood. We investigated the expression of receptor activator of nuclear factor κB (RANK) and RANK ligand (RANKL) in benign and malignant SGTs and their ...
Figen Aslan MD, Ülkü Küçük MD
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