The effects of chitosan oligosaccharides on OPG and RANKL expression in a rat osteoarthritis model [PDF]
Acta Cirúrgica Brasileira, 2017 Purpose: To investigate the effect of chitosan oligosaccharides (COS) against osteoarthritis (OA) and preliminarily discuss the osteoprotegerin (OPG), receptor activator of NF-κB ligand (RANKL) and RANK expression in a rat OA model.
Chun Zhang +6 more
doaj +1 more source
Lipopolysaccharide- TLR-4 Axis regulates Osteoclastogenesis independent of RANKL/RANK signaling
BMC Immunology, 2021 Background Lipopolysaccharide (LPS) is an endotoxin and a vital component of gram-negative bacteria’s outer membrane. During gram-negative bacterial sepsis, LPS regulates osteoclast differentiation and activity, in addition to increasing inflammation ...
Mohammed S. AlQranei +4 more
doaj +1 more source
Effects of RANKL-Targeted Therapy in Immunity and Cancer. [PDF]
, 2014 The role of the receptor activator of nuclear factor-κB ligand (RANKL)/RANK system is well characterized within bone, where RANKL/RANK signaling mediates osteoclastogenesis and bone resorption.
Cheng, Michael L, Fong, Lawrence
core +2 more sources
Evaluation of a novel virtual screening strategy using receptor decoy binding sites [PDF]
, 2016 Virtual screening is used in biomedical research to predict the binding affinity of a large set of small organic molecules to protein receptor targets.
Kukol, A. +3 more
core +2 more sources
Dysregulated RANK Ligand/RANK Axis in Hyperhomocysteinemic Subjects [PDF]
Stroke, 2009 Background and Purpose— Homocysteine has been linked to increased risk of ischemic stroke and other cardiovascular events. Matrix degradation and inflammation play an important role in these disorders, and we have demonstrated increased levels of matrix-degrading enzymes and inflammatory cytokines in
Marit S, Nenseter +8 more
openaire +2 more sources
Evaluation of the effect of topical and systemic ozone application in periodontitis: an experimental study in rats [PDF]
Journal of Applied Oral Science, 2019 Objective: The goal of the present study was to determine the effect of systemic and topical ozone application on alveolar bone loss (ABL) by evaluating the effect of Hypoxia-inducible factor −1 alpha (HIF-1-α) and receptor activator of NF-kB ligand ...
Ebru Saglam +4 more
doaj +2 more sources
Genetically Encoded Photo-cross-linkers Map the Binding Site of an Allosteric Drug on a G Protein-Coupled Receptor [PDF]
, 2012 G protein-coupled receptors (GPCRs) are dynamic membrane proteins that bind extracellular molecules to transduce signals. Although GPCRs represent the largest class of therapeutic targets, only a small percentage of their ligand-binding sites are ...
Abrol, Ravinder +5 more
core +1 more source
Boletín Médico del Hospital Infantil de México, 2022 Duchenne muscular dystrophy (DMD) is an X-linked inherited disorder. Patients present with decreased bone mineral density (BMD) due to glucocorticoid therapy and progressive muscle weakness.
Salvador Atilano-Miguel +2 more
doaj +1 more source
Determination of a predictive cleavage motif for eluted major histocompatibility complex class II ligands [PDF]
, 2018 CD4+ T cells have a major role in regulating immune responses. They are activated by recognition of peptides mostly generated from exogenous antigens through the major histocompatibility complex (MHC) class II pathway.
Dhanda, Sandeep Kumar +7 more
core +6 more sources
Protein-Protein Docking with F2Dock 2.0 and GB-Rerank [PDF]
, 2013 Rezaul Chowdhury is with UT Austin; Muhibur Rasheed is with UT Austin; Maysam Moussalem is with UT Austin; Donald Keidel is with The Scripps Research Institute; Arthur Olson is with The Scripps Research Institute; Michel Sanner is with The Scripps ...
Bajaj, Chandrajit +6 more
core +4 more sources