RANK and RANK Ligand Expression in Parotid Gland Carcinomas [PDF]
Applied Immunohistochemistry & Molecular Morphology, 2018 Recently, it has been reported that deregulation of the receptor activator of NFkB ligand (RANKL)/RANK signaling axis results in salivary gland tumor development in a mouse transgenic model. The aim of this study was to ascertain RANKL and RANK protein expression in a series of primary parotid gland carcinomas and to correlate it with clinicopathologic
Franchi A +6 more
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Dysregulated Osteoprotegerin/RANK Ligand/RANK Axis in Clinical and Experimental Heart Failure [PDF]
Circulation, 2005 Background— Persistent inflammation appears to play a role in the development of heart failure (HF). Osteoprotegerin (OPG), the receptor activator of nuclear factor-κB (RANK), and RANK ligand (RANKL) are newly discovered members of the tumor necrosis factor superfamily that are critical regulators in
Thor Ueland +2 more
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RANK ligand converts the NCoR/HDAC3 co-repressor to a PGC1β- and RNA-dependent co-activator of osteoclast gene expression [PDF]
Molecular Cell, 2023 Yohei Abe, Kristen Jepsen
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The role of rank-ligand inhibition in the treatment of postmenopausal osteoporosis
Reumatismo, 2011 Osteoporosis is a skeletal disease affecting millions of people worldwide in which a decreased bone mass and a microarchitectural deterioration compromise bone strength leading to bone fragility and increased susceptibility to fracture.
M. Varenna, D. Gatti
doaj +6 more sources
Genetic Polymorphisms of RANK, RANKL and their relation to osteoporosis (Polimorfismos genéticos de RANK y RANKL y su relación con la osteoporosis) [PDF]
, 2012 [eng] Osteoporosis is a systemic skeletal disorder and the most common metabolic bone disease. It is recognized as one of the most prevalent problems facing postmenopausal women in western society. The World Health Organization definition of osteoporosis
Yoskovitz, Guy
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Self-Assembled RANK Induces Osteoclastogenesis Ligand-Independently
Journal of Bone and Mineral Research, 2005 Abstract By immunoprecipitation assay, we showed that mouse RANK was self-assembled through its cytoplasmic domain located at position 534–539, whose domain was different form TRAF binding domains. Moreover, overexpression experiments showed that oligomeric RANK, which was self-associated, induced osteoclastogenesis ligand-independently.
Akira Kudo
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Autoregulation of RANK ligand in oral squamous cell carcinoma tumor cells [PDF]
Journal of Cellular Physiology, 2018 Chad Novince +2 more
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Denosumab, a RANK ligand inhibitor, for the management of bone loss in cancer patients
Clinical Interventions in Aging, 2012 Andrew J Yee, Noopur S RajeDivision of Hematology-Oncology, Massachusetts General Hospital Cancer Center, Boston, MA, USAAbstract: Bone loss is a common side effect of cancer treatments, especially antihormonal treatments used in the treatment of breast ...
Yee AJ, Raje NS
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Inflammation is responsible for systemic bone loss in patients with seropositive rheumatoid arthritis treated with rituximab [PDF]
The Korean Journal of Internal Medicine, 2023 Background/Aims We investigated the effect of rituximab on systemic bone metabolism in patients with seropositive rheumatoid arthritis (RA). Methods Twenty seropositive patients with RA were enrolled and administered one cycle of rituximab.
Mie Jin Lim +3 more
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Denosumab use in osteogenesis imperfecta: an update on therapeutic approaches [PDF]
Annals of Pediatric Endocrinology & Metabolism, 2023 Osteogenesis imperfecta (OI) is an inherited skeletal disorder that leads to bone fragility and multiple fractures. Given advances in the genetic understanding of existing phenotypes and newly discovered mutations, therapeutic management of OI has become
Fatma Majdoub +5 more
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