The role of RANK ligand/osteoprotegerin in rheumatoid arthritis [PDF]
Therapeutic Advances in Musculoskeletal Disease, 2012 In the complex system of bone remodeling, the receptor activator of nuclear factor κB ligand (RANKL)/osteoprotegerin (OPG) pathway is the coupling factor between bone formation and bone resorption. RANKL binds to the RANK receptor of pre-osteoclasts and mature osteoclasts and stimulates their activation and differentiation.
Piet Geusens
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The role of rank-ligand inhibition in the treatment of postmenopausal osteoporosis
Reumatismo, 2011 Osteoporosis is a skeletal disease affecting millions of people worldwide in which a decreased bone mass and a microarchitectural deterioration compromise bone strength leading to bone fragility and increased susceptibility to fracture.
M. Varenna, D. Gatti
doaj +6 more sources
Rank ligand as a target in musculoskeletal neoplasms. [PDF]
Curr Rev Musculoskelet Med, 2015 Receptor activator of nuclear factor-κB ligand (RANKL) is a tumor necrosis factor (TNF) family member, which signals through the osteoclast surface RANK. As such, RANKL is required for osteoclast differentiation and function, namely bone resorption. There is now growing evidence that RANKL is a therapeutic target for musculoskeletal neoplasms, namely ...
Cote GM.
europepmc +4 more sources
Discontinuing Denosumab: Can It Be Done Safely? A Review of the Literature [PDF]
Endocrinology and Metabolism, 2022 Denosumab, which has been approved for the treatment of osteoporosis since 2010, is a fully humanised monoclonal antibody against a cytokine, receptor activator of nuclear factor kappa B ligand (RANKL), involved in bone resorption.
Wei Lin Tay, Donovan Tay
doaj +1 more source
Tocotrienol regulates osteoclastogenesis in rheumatoid arthritis [PDF]
The Korean Journal of Internal Medicine, 2021 Background/Aims The present study aimed to investigate whether tocotrienol regulates interleukin 17 (IL-17)-induced osteoclastogenesis in rheumatoid arthritis (RA).
Kyoung-Woon Kim +6 more
doaj +1 more source
NIP45 negatively regulates RANK ligand induced osteoclast differentiation [PDF]
Journal of Cellular Biochemistry, 2012 Srinivasan Shanmugarajan
exaly +2 more sources
N-acetyl-l-cysteine controls osteoclastogenesis through regulating Th17 differentiation and RANKL in rheumatoid arthritis [PDF]
The Korean Journal of Internal Medicine, 2019 Background/Aims This study aimed to determine the regulatory role of N-acetyl-l-cysteine (NAC), an antioxidant, in interleukin 17 (IL-17)-induced osteoclast differentiation in rheumatoid arthritis (RA).
Hae-Rim Kim +4 more
doaj +1 more source
Breast Cancer: Rank Ligand Inhibition. [PDF]
Breast Care (Basel), 2010 Breast cancer and bone health are closely linked. Early menopause induced by gonadotropin-releasing hormone analogues or chemotherapy as well as aromatase inhibitors reduce oestrogen levels, thereby causing cancer treatment-induced bone loss (CTIBL). Furthermore, bone metastases are commonly found in advanced disease. Current treatment options for bone
Bartsch R +3 more
europepmc +4 more sources
RANK and RANK Ligand Expression in Parotid Gland Carcinomas [PDF]
Applied Immunohistochemistry & Molecular Morphology, 2018 Recently, it has been reported that deregulation of the receptor activator of NFkB ligand (RANKL)/RANK signaling axis results in salivary gland tumor development in a mouse transgenic model. The aim of this study was to ascertain RANKL and RANK protein expression in a series of primary parotid gland carcinomas and to correlate it with clinicopathologic
Franchi A +6 more
openaire +4 more sources
Receptor activator of NF-kappaB and podocytes: towards a function of a novel receptor-ligand pair in the survival response of podocyte injury. [PDF]
PLoS ONE, 2012 BACKGROUND: Glomerulosclerosis correlates with reduction in podocyte number that occurs through mechanisms which include apoptosis. Podocyte injury or podocyte loss in the renal glomerulus has been proposed as the crucial mechanism in the development of ...
Shuangxin Liu +17 more
doaj +1 more source