Correlating RANK Ligand/RANK Binding Kinetics With Osteoclast Formation and Function [PDF]
Journal of Cellular Biochemistry, 2015 ABSTRACTThe interaction between Receptor Activator of NF‐κB Ligand (RANKL) and its receptor RANK is essential for the differentiation and bone resorbing capacity of the osteoclast. Osteoprotegerin (OPG), a soluble homodimer, acts as a decoy receptor for RANKL and thus inhibits osteoclastogenesis.
Julia T, Warren +6 more
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DeepBindPoc: a deep learning method to rank ligand binding pockets using molecular vector representation [PDF]
PeerJ, 2020 Accurate identification of ligand-binding pockets in a protein is important for structure-based drug design. In recent years, several deep learning models were developed to learn important physical–chemical and spatial information to predict ligand ...
Haiping Zhang +6 more
doaj +3 more sources
RANK Ligand Helps Immunity to Leishmania major by Skewing M2-Like Into M1 Macrophages [PDF]
Frontiers in Immunology, 2020 Macrophages host Leishmania major infection, which causes cutaneous Leishmaniasis in humans. In the murine model, resistance to infection depends on the host immunity mediated by CD4 T-cell cytokines and macrophages.
Thaís S. Rigoni +9 more
doaj +2 more sources
Rank ligand as a target in musculoskeletal neoplasms [PDF]
Current Reviews in Musculoskeletal Medicine, 2015 Receptor activator of nuclear factor-κB ligand (RANKL) is a tumor necrosis factor (TNF) family member, which signals through the osteoclast surface RANK. As such, RANKL is required for osteoclast differentiation and function, namely bone resorption. There is now growing evidence that RANKL is a therapeutic target for musculoskeletal neoplasms, namely ...
Cote GM.
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Dysregulated Osteoprotegerin/RANK Ligand/RANK Axis in Clinical and Experimental Heart Failure [PDF]
Circulation, 2005 Background— Persistent inflammation appears to play a role in the development of heart failure (HF). Osteoprotegerin (OPG), the receptor activator of nuclear factor-κB (RANK), and RANK ligand (RANKL) are newly discovered members of the tumor necrosis factor superfamily that are critical regulators in
Thor, Ueland +9 more
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NIP45 negatively regulates RANK ligand induced osteoclast differentiation [PDF]
Journal of Cellular Biochemistry, 2012 AbstractReceptor activator of NF‐κB ligand (RANKL)‐RANK receptor signaling to induce NFATc1 transcription factor is critical for osteoclast differentiation and bone resorption. RANK adaptor proteins, tumor necrosis factor receptor‐associated factors (TRAFs) play an essential role in RANKL signaling.
Srinivasan, Shanmugarajan +3 more
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Histological Regression of Giant Cell Tumor of Bone Following RANK Ligand Inhibition [PDF]
Journal of Investigative Medicine High Impact Case Reports, 2014 Lung metastases are a rare complication of giant cell tumors of bone. We herein describe an interesting case of histological regression and size reduction of lung metastases originating from a primary giant cell tumor of bone in response to the RANK ...
Martin F. Dietrich MD, PhD +3 more
doaj +2 more sources
The role of RANK ligand/osteoprotegerin in rheumatoid arthritis [PDF]
Therapeutic Advances in Musculoskeletal Disease, 2012 In the complex system of bone remodeling, the receptor activator of nuclear factor κB ligand (RANKL)/osteoprotegerin (OPG) pathway is the coupling factor between bone formation and bone resorption. RANKL binds to the RANK receptor of pre-osteoclasts and mature osteoclasts and stimulates their activation and differentiation. The production of RANKL/OPG
Geusens P.
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Receptor activator of NF-kappaB and podocytes: towards a function of a novel receptor-ligand pair in the survival response of podocyte injury. [PDF]
PLoS ONE, 2012 BACKGROUND: Glomerulosclerosis correlates with reduction in podocyte number that occurs through mechanisms which include apoptosis. Podocyte injury or podocyte loss in the renal glomerulus has been proposed as the crucial mechanism in the development of ...
Shuangxin Liu +17 more
doaj +1 more source
The effects of chitosan oligosaccharides on OPG and RANKL expression in a rat osteoarthritis model [PDF]
Acta Cirúrgica Brasileira, 2017 Purpose: To investigate the effect of chitosan oligosaccharides (COS) against osteoarthritis (OA) and preliminarily discuss the osteoprotegerin (OPG), receptor activator of NF-κB ligand (RANKL) and RANK expression in a rat OA model.
Chun Zhang +6 more
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