Results 181 to 190 of about 53,728 (264)

Cardiovascular safety of osteoanabolic agents. [PDF]

J Bone Miner Metab
Takeuchi Y.
europepmc   +1 more source

Identification of a Distal Enhancer That Regulates TGF‐β–Induced SNAI1 Expression

Cancer Science, EarlyView.
In TGF‐β–stimulated cells, the activated Smad complex composed of Smad3 and Smad4 associates with the distal super enhancer region 2 (DSE2) and enhances its interaction with the SNAI1 proximal promoter, thus inducing SNAI1 expression. RREB1 regulates the basal activity of the enhancer but not its inducibility by TGF‐β.
Hao Fu, Yuka Itoh, Tomoe Sawaguchi, Shigeo Otake, Chiho Omata, Masao Saitoh, Keiji Miyazawa   +6 more
wiley   +1 more source

Challenges in managing osteogenesis imperfecta in a resource-limited setting: a case report. [PDF]

J Med Case Rep
Richard S, Robert N, Sambo VDC, Daniel A, Ronald O.   +4 more
europepmc   +1 more source

PC4 Potentially Predicts Chemoradiation‐Induced Antitumor Immunity in Esophageal Squamous Cell Carcinoma

Cancer Science, EarlyView.
In present study, we describe the tumor‐infiltrating CD8+T cells pattern induced by neoadjuvant chamoradiation (CRT) in human esophageal squamous cell carcinoma (ESCC), and reveal that PC4 expression predicted CRT‐induced antitumor immune response with high probability and may help stratify subgroups with better prognosis in patients with locally ...
Jieyong Tian, Xiaoying Wei, Huiquan Liu, Qingsong Pang, Dong Qian, Haiming Dai   +5 more
wiley   +1 more source

Evolving strategies for osteoporosis management in postmenopausal women: From tradition to innovation. [PDF]

Medicine (Baltimore)
Akbar A, Zaheer A, Kharal MM, Komel A, Khan MH, Ahsan A, Singh AK.   +6 more
europepmc   +1 more source

Organoid Models to Study Human Infectious Diseases

Cell Proliferation, EarlyView.
Our manuscript reviews the role of organoids as models for studying human infectious diseases, highlighting their irreplaceable contributions to drug testing and vaccine development for significant infectious diseases including HIV, ZIKV, SARS‐CoV‐2 and MPXV.
Sijing Zhu, Dan Chen, Xinzhi Yang, Liuliu Yang, Yuling Han   +4 more
wiley   +1 more source

Efficacy and safety of sequential therapy for primary osteoporosis with bone formation promoters followed by bone resorption inhibitors: a meta-analysis. [PDF]

J Orthop Surg Res
Liu Y, Liu X, Wu Y, Luo T.
europepmc   +1 more source

Mechanism of EC‐EXOs‐Derived THBS3 Targeting CD47 to Regulate BMSCs Differentiation to Ameliorate Bone Loss

Cell Proliferation, EarlyView.
EC‐EXOs could regulate the differentiation of BMSCs through the key protein THBS3, which inhibits their differentiation to lipogenic cells and promotes their differentiation to osteoblasts. THBS3 could down‐regulate the expression of its downstream target CD47 and delay the process of bone loss in aged mice and OVX mice, which may provide a novel ...
Jiaojiao Wang, Zhaokai Zhou, Wenjie Chen, Yun Chen, Qiyue Zheng, Yajun Chen, Zhengxiao Ouyang, Ran Xu, Qiong Lu   +8 more
wiley   +1 more source

Dental Implant Survival and Risk of Medication-Related Osteonecrosis in the Jaws in Patients Undergoing Antiresorptive Therapy: A Systematic Review. [PDF]

Int J Mol Sci
Crupi A, Lanzetti J, Todaro D, Pera F, Erovigni FM.   +4 more
europepmc   +1 more source

Macrophage Efferocytosis as a Therapeutic Strategy in Intervertebral Disc Degeneration

Cell Proliferation, EarlyView.
Macrophages, integral to degenerated intervertebral discs, play a critical role in disc degeneration. By performing efferocytosis, they clear apoptotic cells. This article explores the process of efferocytosis, its molecular mechanisms, potential therapeutic implications for intervertebral disc degeneration and future strategies for targeted treatments.
Shijie Chen, Haijun Zhang, Zhaoheng Wang, Daxue Zhu, Yanhu Li, Yizhi Zhang, Dongxin Wang, Shuwei Chen, Huan Liu, Xuewen Kang   +9 more
wiley   +1 more source