Results 191 to 200 of about 53,728 (264)

RNF219 RING Finger Domain Mutants Drive Phase Separation to Encapsulate CCR4‐NOT and Promote Cell Proliferation

open access: yesCell Proliferation, EarlyView.
Mutations in the RING finger domain (C3HC4) of RNF219 promote the formation of RNF219 condensates, which are able to encapsulate the CCR4‐NOT complex. These RNF219Mut‐CCR4‐NOT condensates reduce the deacetylation activity of the CCR4‐NOT complex and induce cell proliferation.
Chen Chen   +4 more
wiley   +1 more source

Cost-effectiveness analysis of romosozumab for severe postmenopausal osteoporosis at very high risk of fracture in Mexico. [PDF]

open access: yesPLoS One
Diaz Martinez JP   +4 more
europepmc   +1 more source

Role of Histone Deacetylase and Inhibitors in Cardiovascular Diseases

open access: yesCell Proliferation, EarlyView.
HDACs play an important role in the occurrence and development of cardiovascular diseases, such as myocardial hypertrophy, hypertension, and atherosclerosis. HDAC inhibitors have broad prospects for the treatment of CVD, and different HDAC subtypes can act through different mechanisms.
Li‐Ying Zhang   +4 more
wiley   +1 more source

Illegal trade of crocodylians in Colombia: Spatiotemporal dynamics and implications on conservation efforts

open access: yesConservation Science and Practice, EarlyView.
Crocodylian conservation effectiveness has been limited by illegal trade as well as changes in control and trade policies. We assessed spatiotemporal dynamics of illegal crocodylian trade in Colombia from 2010 to 2022 based on data collected by regional and district environmental authorities and discussed its implications on conservation efforts ...
Edison D. Bonilla‐Liberato   +4 more
wiley   +1 more source

Successful first rehabilitation and release of an endangered Ethiopian wolf

open access: yesConservation Science and Practice, EarlyView.
Wildlife rehabilitation is widely practiced to help injured animals recover and return to the wild, particularly benefiting endangered species that have small local populations. Here, we report the first case of a rehabilitated Ethiopian wolf that was successfully released back in the Simien Mountains.
Sandra Lai   +7 more
wiley   +1 more source

Bridging the gap in obesity research: A consensus statement from the European Society for Clinical Investigation

open access: yesEuropean Journal of Clinical Investigation, EarlyView.
This consensus highlights critical research gaps in obesity epidemiology, phenotypic heterogeneity and clinical management, calling for advanced methodologies, collaborative strategies and innovative policies to mitigate the global obesity epidemic and its socio‐economic impacts.
Federico Carbone   +28 more
wiley   +1 more source

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