Results 21 to 30 of about 371,333 (281)
Drugs, 2021 The number of patients on long-term anti-osteoporotic drug therapy is rising. Unfortunately, there are few data to guide decisions about duration of pharmacologic therapy for osteoporosis.
L. Elbers, H. Raterman, W. Lems
semanticscholar +1 more source
Nanoroughness, Surface Chemistry and Drug Delivery Control by Atmospheric Plasma Jet on Implantable Devices [PDF]
, 2018 Implantable devices need specific tailored surface morphologies and chemistries to interact with the living systems or to actively induce a biological response also by the release of drugs or proteins.
Ambrosi, Emmanuele +8 more
core +3 more sources
Transplantation Reports, 2022 Background: Osteoporosis is a prevalent complication in heart transplant population. Denosumab is a monoclonal antibody that inhibits bone resorption approved for the treatment of corticosteroid-induced osteoporosis and potentially useful in heart ...
Juan C. Uzquiano +5 more
doaj
Reversal of the diabetic bone signature with anabolic therapies in mice
Bone Research, 2023 The mechanisms underlying the bone disease induced by diabetes are complex and not fully understood; and antiresorptive agents, the current standard of care, do not restore the weakened bone architecture.
Silvia Marino +11 more
semanticscholar +1 more source
Rocaglates as dual-targeting agents for experimental cerebral malaria [PDF]
, 2018 Cerebral malaria (CM) is a severe and rapidly progressing complication of infection by Plasmodium parasites that is associated with high rates of mortality and morbidity.
Ayi, Kodjo +12 more
core +1 more source
Journal of Bone Oncology, 2022 Background: Giant-cell tumor of bone (GCTB) is a relatively benign, but locally aggressive osteoclastogenic stromal tumour of the bone. Although denosumab has been approved as an monoclonal antibody against RANK ligand for the treatment of GCTB, few ...
Jiaji Yue, Wei Sun, Shenglong Li
doaj
Bone Adaptation as a Geometric Flow [PDF]
arXiv, 2021 This paper presents bone adaptation as a geometric flow. The proposed method is based on two assumptions: first, that the bone surface is smooth (not fractal) permitting the definition of a tangent plane and, second, that the interface between marrow and bone tissue phases is orientable.
arxiv
Change in Bone Density and Reduction in Fracture Risk: A Meta‐Regression of Published Trials
Journal of Bone and Mineral Research, 2019 Meta‐analyses conducted >15 years ago reported that improvements in bone mineral density (BMD) were associated with reduction in vertebral and nonvertebral fractures in osteoporosis trials.
M. Bouxsein +9 more
semanticscholar +1 more source
Journal of Bone and Mineral Research, 2023 An imbalance between bone resorption and bone formation underlies the devastating osteolytic lesions and subsequent fractures seen in more than 90% of multiple myeloma (MM) patients.
Marija K Simic +8 more
semanticscholar +1 more source
Osteocytes as a record of bone formation dynamics: A mathematical model of osteocyte generation in bone matrix [PDF]
J Theor Biol 364: 418-427 (2015), 2014 The formation of new bone involves both the deposition of bone matrix, and the formation of a network of cells embedded within the bone matrix, called osteocytes. Osteocytes derive from bone-synthesising cells (osteoblasts) that become buried in bone matrix during bone deposition.
arxiv +1 more source