Results 21 to 30 of about 55,987 (284)

Reversal of the diabetic bone signature with anabolic therapies in mice

Bone Research, 2023
The mechanisms underlying the bone disease induced by diabetes are complex and not fully understood; and antiresorptive agents, the current standard of care, do not restore the weakened bone architecture.
Silvia Marino, Nisreen S Akel, Shenyang Li, M. Cregor, Meghan Jones, Betiana Pérez, Gaston Troncoso, Jomeeka Meeks, Scott Stuart, Amy Y. Sato, I. Nookaew, T. Bellido   +11 more
semanticscholar   +1 more source

Change in Bone Density and Reduction in Fracture Risk: A Meta‐Regression of Published Trials

Journal of Bone and Mineral Research, 2019
Meta‐analyses conducted >15 years ago reported that improvements in bone mineral density (BMD) were associated with reduction in vertebral and nonvertebral fractures in osteoporosis trials.
M. Bouxsein, R. Eastell, L. Lui, Lucy A Wu, A. D. de Papp, A. Grauer, F. Marin, J. Cauley, D. Bauer, D. Black   +9 more
semanticscholar   +1 more source

Multi‐Targeting DKK1 and LRP6 Prevents Bone Loss and Improves Fracture Resistance in Multiple Myeloma

Journal of Bone and Mineral Research, 2023
An imbalance between bone resorption and bone formation underlies the devastating osteolytic lesions and subsequent fractures seen in more than 90% of multiple myeloma (MM) patients.
Marija K Simic, Sindhu T. Mohanty, Ya Xiao, T. Cheng, Victoria E Taylor, O. Charlat, Michael P. Daley, P. Croucher, M. McDonald   +8 more
semanticscholar   +1 more source

Coronectomy of deeply impacted lower third molar : incidence of outcomes and complications after one year follow-up [PDF]

, 2015
Objectives: The purpose of present study was to assess the surgical management of impacted third molar with proximity to the inferior alveolar nerve and complications associated with coronectomy in a series of patients undergoing third molar surgery ...
Ajbage, Jimoh Olubanwo, Heijsters, Guido, Politis, Constantinus, Salem, Ahmed Sobhy, Schepers, Serge, Van Slycke, Sarah, Vrielinck, Luc   +6 more
core   +3 more sources

Diretrizes para prevenção e tratamento da osteoporose induzida por glicocorticoide Guidelines for the prevention and treatment of glucocorticoid-induced osteoporosis

Revista Brasileira de Reumatologia, 2012
Os glicocorticoides (GC) são prescritos por praticamente todas as especialidades médicas, e cerca de 0,5% da população geral do Reino Unido utiliza esses medicamentos.
Rosa Maria Rodrigues Pereira, Jozélio Freire de Carvalho, Ana Patrícia Paula, Cristiano Zerbini, Diogo S. Domiciano, Helenice Gonçalves, Jaime S. Danowski, João F. Marques Neto, Laura M. C. Mendonça, Mailze C. Bezerra, Maria Teresa Terreri, Marta Imamura, Pedro Weingrill, Perola G. Plapler, Sebastião Radominski, Tatiana Tourinho, Vera L. Szejnfeld, Nathalia C. Andrada   +17 more
doaj   +1 more source

Difference in Bone Mineral Density Change at the Lateral Femoral Cortices according to Administration of Different Bisphosphonate Agents

Journal of Bone Metabolism, 2016
Background To retrospectively assess whether the response of subtrochanteric lateral cortex (STLC) is different according to the bisphosphonate agents in terms of bone mineral density (BMD) change.
Sungjun Kim, Hyunhee Bang, Hanna Yoo, I. Park, K. Yang, Hyunsun Lim, W. Jung   +6 more
semanticscholar   +1 more source

Computer simulation of glioma growth and morphology [PDF]

, 2007
Despite major advances in the study of glioma, the quantitative links between intra-tumor molecular/cellular properties, clinically observable properties such as morphology, and critical tumor behaviors such as growth and invasiveness remain unclear ...
Adam, Ambrosi, Ambrosi, Anderson, Anderson, Anderson, Anderson, Araujo, Augustin, Bartels, Bello, Bellomo, Berger, Bernsen, Bernsen, Boegler, Brandt, Bullitt, Byrne, Byrne, Byrne, Byrne, Cai, Carmeliet, Chaplain, Chaplain, Chaplain, Chaplain, Condeelis, Cristini, Cristini, Cursiefen, DeJaeger, Derycke, Eble, Elaine L. Bearer, Ellis, Elvin, Fallenstein, Frieboes, Friedl, Friedl, Friedl, Friedman, Garcke, Gatenby, Giese, Greenspan, Hayot, Helmlinger, Hermann B. Frieboes, Holash, Holash, Huang, Jacqmin, Jain, Jain, John S. Lowengrub, Keller, Khoshyomn, Kim, Kim, Kim, Kopfstein, Kuiper, Kumar, Kunkel, Lah, Lamszus, Lee, Leo, Less, Li, Li, Lockett, Lowengrub, Macklin, Macklin, McDougall, McLean, Naganuma, O'Connor, Ommaya, Padera, Page, Patan, Patan, Paul Macklin, Pennacchietti, Plank, Plank, Preusser, Ridley, Rofstad, Rubenstein, S. Wise, Sahai, Sanga, Seftor, Shweiki, Sierra, Sinek, Skinner, Steeg, Sun, Takano, Toker, Tysnes, Vajkoczy, van Kempen, Vittorio Cristini, Wise, Wolf, Wurzel, X. Zheng, Yamaguchi, Yin, Zheng   +117 more
core   +1 more source

A Single Infusion of Zoledronate in Postmenopausal Women Following Denosumab Discontinuation Results in Partial Conservation of Bone Mass Gains

Journal of Bone and Mineral Research, 2020
Discontinuation of denosumab is associated with a rapid return of bone mineral density (BMD) to baseline and an increased risk of multiple vertebral fractures.
J. Everts-Graber, S. Reichenbach, H. Ziswiler, U. Studer, Thomas Lehmann   +4 more
semanticscholar   +1 more source

Reporting guidelines, review of methodological standards, and challenges toward harmonization in bone marrow adiposity research. Report of the Methodologies Working Group of the International Bone Marrow Adiposity Society [PDF]

, 2020
The interest in bone marrow adiposity (BMA) has increased over the last decade due to its association with, and potential role, in a range of diseases (osteoporosis, diabetes, anorexia, cancer) as well as treatments (corticosteroid, radiation ...
et al,, Scheller, Erica L, Tratwal, Josefine   +2 more
core   +1 more source

Novel cathepsin K inhibitors block osteoclasts in vitro and increase spinal bone density in zebrafish

RSC Advances, 2019
Cathepsin K (Cat K) is a predominant cysteine protease and highly potent collagenase expressed in osteoclasts. Cat K inhibitors are anti-resorptive agents to treat osteoporosis. A novel scaffold of cathepsin K inhibitors, exemplified by lead compound 1x,
Si-tu Xue, Yali Wang, Xiaowan Han, Hong Yi, Wei Jiang, S. Si, Hui-fang Guo, Zhuo-rong Li   +7 more
semanticscholar   +1 more source