Results 81 to 90 of about 371,333 (281)

Denosumab versus zoledronic acid in cases of surgically unsalvageable giant cell tumor of bone: A randomized clinical trial

Journal of Bone Oncology, 2019
Background: Although denosumab has been approved as an antiresorptive agent for giant cell tumor of bone, its efficacy has not been proven. Objectives: To compare the efficacy and safety of denosumab and zoledronic acid treatment in patients with ...
Shenglong Li, Peng Chen, Qiankun Yang
doaj  

High-resolution coproecology: Using coprolites to reconstruct the habits and habitats of New Zealand’s extinct upland Moa (Megalapteryx didinus) [PDF]

, 2005
Knowledge about the diet and ecology of extinct herbivores has important implications for understanding the evolution of plant defence structures, establishing the influences of herbivory on past plant community structure and composition, and identifying
Wood, Jamie R., Wilmshurst, Janet M., Wagstaff, Steven J., Worthy, Trevor H., Rawlence, Nicolas J., Cooper, Alan   +5 more
core   +4 more sources

Generation of Neural Organoids and Their Application in Disease Modeling and Regenerative Medicine

Advanced Science, EarlyView.
Neural organoids provide a versatile platform for neurological research. Advances in organoid technology have partially achieved human neural tissue complexity in terms of tissue structure, cell diversity, and neural signaling, offering insights into neural disorders and regenerative strategies. Technology advances from biomaterials, bio‐manufacturing,
Ruiqi Huang, Feng Gao, Liqun Yu, Haokun Chen, Rongrong Zhu   +4 more
wiley   +1 more source

The Research Space: using the career paths of scholars to predict the evolution of the research output of individuals, institutions, and nations

, 2016
In recent years scholars have built maps of science by connecting the academic fields that cite each other, are cited together, or that cite a similar literature.
Aristarán, Manuel, Guevara, Miguel R., Hartmann, Dominik, Hidalgo, César A., Mendoza, Marcelo   +4 more
core   +1 more source

Mice, scats and burials: unusual concentrations of microfauna found in human burials at the Neolithic site of Catalhoyuk, Central Anatolia [PDF]

, 2012
Three human burials were found at Çatalhöyük that contained large microfaunal assemblages. Taphonomic analysis demonstrated that many of these elements had passed through the digestive tract of a small carnivore, indicating that the microfauna entered ...
Jenkins, Emma L.
core   +1 more source

Kinsenoside‐Loaded Microneedle Accelerates Diabetic Wound Healing by Reprogramming Macrophage Metabolism via Inhibiting IRE1α/XBP1 Signaling Axis

Advanced Science, EarlyView.
Gut metabolite trimethylamine N‐oxide accumulates in the diabetic wound area to amplify macrophage inflammation via enhancing glycolysis activities. Kinsenoside induces macrophage repolarization from M1 to M2 phenotype through inhibiting IRE1α/XBP1 pathway, followed by HIF‐1α‐glycolysis axis repression and mitophagy‐oxidative phosphorylation axis ...
Li Lu, Jiewen Liao, Chao Xu, Yuan Xiong, Juan Zhou, Guangji Wang, Ze Lin, Kangkang Zha, Chuanlu Lin, Ruiyin Zeng, Guandong Dai, Qian Feng, Bobin Mi, Guohui Liu   +13 more
wiley   +1 more source

Response rates for hip, femoral neck, and lumbar spine bone mineral density in patients treated with abaloparatide followed by alendronate: Results from phase 3 ACTIVExtend

Bone Reports, 2019
Abaloparatide is a selective activator of the parathyroid hormone type 1 receptor signaling pathway that favors the stimulation of bone formation. Here, we report a prospective, exploratory analysis of bone mineral density (BMD) response rates comparing ...
Chad L. Deal, Bruce H. Mitlak, Yamei Wang, Lorraine A. Fitzpatrick, Paul D. Miller   +4 more
doaj  

Change in bone mineral density as a function of age in women and men and association with the use of antiresorptive agents

Canadian Medical Association Journal, 2008
Background: Measurement of bone mineral density is the most common method of diagnosing and assessing osteoporosis. We sought to estimate the average rate of change in bone mineral density as a function of age among Canadians aged 25–85, stratified by ...
C. Berger, L. Langsetmo, L. Joseph, D. Hanley, K. Davison, R. Josse, N. Kreiger, A. Tenenhouse, D. Goltzman   +8 more
semanticscholar   +1 more source

Light‐Driven PAA Adhesive: A Green Bonding Platform Integrating High‐Performance, Environmental Resilience, and Closed‐Loop Recyclability

Advanced Science, EarlyView.
This investigation introduces the formulation of a cutting‐edge, robust polyacrylic aqueous adhesive (PAA), synthesized through the employment of visible‐light initiated polymerization. The adhesive demonstrates minimal energy demand, environmental friendliness, robust adhesive properties (20.86 MPa on wood), remarkable thermal stability (with ...
Xueying Fu, Jingtian Chen, Yuqi Zhao, Yanan Liu, Chenyang Xie, Xuhang Zhang, Yingdan Liu, Jingyue Yang   +7 more
wiley   +1 more source

Inhibition of Heat Shock Protein 90β by Catalpol: A Potential Therapeutic Approach for Alleviating Inflammation‐Induced Cartilage Injuries in Osteoarthritis

Advanced Science, EarlyView.
The schematic diagram delineates the chondroprotective effects of Ca‐bMSN in OA models. The upper portion of the diagram depicts the synthesis process of Ca‐bMSN. The lower section illustrates the post‐injection of Ca‐bMSN in joint cavity, catalpol released and subsequently mediates the reduction of oxidative stress, ECM catabolism, apoptosis, and ...
Zhenwei Zhou, Binghua Zhang, Lang Liu, Jie Yang, Yuting Wang, Cheng Lv, He Zhang, Yuchi Wei, Zhanliang Jiang, Zeyu Peng, Daqing Zhao, Xiangyang Leng, Xiangyan Li, Hang Su, Haisi Dong   +14 more
wiley   +1 more source