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A narrative review of diabetic bone disease: Characteristics, pathogenesis, and treatment
Frontiers in Endocrinology, 2022 Recently, the increasing prevalence of diabetes mellitus has made it a major chronic illness which poses a substantial threat to human health. The prevalence of osteoporosis among patients with diabetes mellitus has grown considerably.
Bo Wu +6 more
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Bone Disease in Multiple Myeloma: Biologic and Clinical Implications
Cells, 2022 Multiple Myeloma (MM) is a hematologic malignancy characterized by the proliferation of monoclonal plasma cells localized within the bone marrow. Bone disease with associated osteolytic lesions is a hallmark of MM and develops in the majority of MM ...
Z. Bernstein, E. B. Kim, N. Raje
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Myeloma Bone Disease: A Comprehensive Review
International Journal of Molecular Sciences, 2021 Multiple myeloma (MM) is a neoplastic clonal proliferation of plasma cells in the bone marrow microenvironment, characterized by overproduction of heavy- and light-chain monoclonal proteins (M-protein). These proteins are mainly found in the serum and/or
S. Mukkamalla, Dhatri Malipeddi
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Medicina, 2022 Background and Objectives: Oxytocin (OT) is a neuropeptide hormone which is known for its classical effects in pregnancy and lactation. Recently, growing evidence demonstrated a close relation between OT and bone.
Wei-Jia Yu +9 more
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BMC Geriatrics, 2021 Background Osteoporosis and sarcopenia are major health issues in postmenopausal women due to their high prevalence and association with several adverse outcomes. However, no biomarkers may be used for screening and diagnosis.
Yanping Du +9 more
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Frontiers in Endocrinology, 2021 ObjectiveThe current study was conducted to determine whether peak bone mineral density (BMD) and obesity phenotypes are associated with certain LGR4 gene polymorphisms found in Chinese nuclear families with female children.MethodsA total of 22 single ...
Su-qin Shi +10 more
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Novel mutations in BMP1 result in a patient with autosomal recessive osteogenesis imperfecta
Molecular Genetics & Genomic Medicine, 2021 Background Osteogenesis imperfecta (OI) is a rare heritable bone disorder that is characterised by increased bone fragility and recurrent fractures. To date, only 19 OI patients have been reported, as caused by BMP1 gene mutations, worldwide.
Lei Xi +3 more
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Skeletal Muscle, 2023 We investigated the effect of eldecalcitol on disuse muscle atrophy. C57BL/6J male mice aged 6 weeks were randomly assigned to control, tail suspension (TS), and TS-eldecalcitol–treated groups and were injected intraperitoneally twice a week with either ...
Haichao Zhang +7 more
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Eldecalcitol prevents muscle loss by suppressing PI3K/AKT/FOXOs pathway in orchiectomized mice
Frontiers in Pharmacology, 2022 Elderly male patients are susceptible to develop osteoporosis and sarcopenia, especially those with fragility fractures, hypogonadism, and prostate cancer with androgen deprivation therapy.
Haichao Zhang +7 more
doaj +1 more source
Journal of Translational Medicine, 2023 Background Ankylosing spondylitis (AS) is an autoimmune disease with a genetic correlation and is characterized by inflammation in the axial skeleton and sacroiliac joints.
Xinzhe Feng +5 more
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