Results 11 to 20 of about 245,440 (214)

Relationship between bone mineral density and fragility fracture risk: a case-control study in Changsha, China

open access: yesBMC Musculoskeletal Disorders, 2021
Background Fragility fracture is associated with bone mineral density (BMD), and most databases used in related researches are instrument-matched.
Hong-Li Li   +11 more
doaj   +1 more source

Ferroptosis and Its Potential Role in Metabolic Diseases: A Curse or Revitalization?

open access: yesFrontiers in Cell and Developmental Biology, 2021
Ferroptosis is classified as an iron-dependent form of regulated cell death (RCD) attributed to the accumulation of lipid hydroperoxides and redox imbalance.
Jia-Yue Duan   +13 more
doaj   +1 more source

Antiproliferative Properties of Oleuropein in Human Osteosarcoma Cells

open access: yesNatural Product Communications, 2016
In this study, we evaluated the antiproliferative activity on two human osteosarcoma cell lines (MG-63 and Saos2) of oleuropein, an olive oil compound traditionally found in the Mediterranean diet.
Jose M. Moran   +6 more
doaj   +1 more source

Hereditary severe insulin resistance syndrome: Pathogenesis, pathophysiology, and clinical management

open access: yesGenes and Diseases, 2023
Severe insulin resistance has been linked to some of the most globally prevalent disorders, such as diabetes mellitus, nonalcoholic fatty liver disease, polycystic ovarian syndrome, and hypertension. Hereditary severe insulin resistance syndrome (H-SIRS)
Junaid Iqbal   +9 more
doaj   +1 more source

Effect of Body Surface Area on Severe Osteoporotic Fractures: A Study of Osteoporosis in Changsha China

open access: yesFrontiers in Endocrinology, 2022
Clinical vertebral fractures and femoral neck fractures are severe osteoporotic fractures that increase morbidity and mortality. Anthropometric variables are associated with an increased risk of osteoporotic fractures, but it is not clear whether body ...
Xi-Yu Wu   +9 more
doaj   +1 more source

Zoledronic acid and atorvastatin inhibit αvβ3-mediated adhesion of breast cancer cells

open access: yesJournal of Bone Oncology, 2014
Bone metastases represent common long term complications of patients with breast cancer. Zoledronic acid, an amino-bisphosphonate and mevalonate pathway inhibitor, is an established agent for the treatment of bone metastases.
Maria Wilke   +8 more
doaj   +1 more source

Exosomes as Mediators of Cell-to-Cell Communication in Thyroid Disease

open access: yesInternational Journal of Endocrinology, 2020
Exosomes are a type of extracellular vehicle, formed by budding cell membranes, containing proteins, DNA, and RNA. Concentrated cargoes from parent cells are enveloped in exosomes, which are cell specific and may have functions in the recipient cell ...
Yi Wang   +7 more
doaj   +1 more source

Exosomes and Obesity-Related Insulin Resistance

open access: yesFrontiers in Cell and Developmental Biology, 2021
Exosomes are extracellular vesicles, delivering signal molecules from donor cells to recipient cells. The cargo of exosomes, including proteins, DNA and RNA, can target the recipient tissues and organs, which have an important role in disease development.
Li-Min Lei   +9 more
doaj   +1 more source

A novel antimicrobial peptide derived from human BPIFA1 protein protects against infection

open access: yesInnate Immunity, 2022
Bactericidal/permeability-increasing fold containing family A, member 1 (BPIFA1) is an innate immunity defense protein. Our previous studies proved its antibacterial and antiviral effects, but its role in fungi remains unknown.
Nan Hu   +6 more
doaj   +1 more source

Role of VEGF Polymorphisms in the Susceptibility and Severity of Interstitial Lung Disease

open access: yesBiomedicines, 2021
The search for biomarkers that can help to establish an early diagnosis and prognosis of interstitial lung disease (ILD) is of potential interest. VEGF polymorphisms have been implicated in the development of several lung disorders.
Sara Remuzgo-Martínez   +18 more
doaj   +1 more source

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