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Clinical Biochemistry, 2012
To review recent advance in understanding the causation and management of Paget's disease.We review recent publications concerning the aetiology of the disease and the use of biochemical markers of bone turnover in diagnosis and treatment.Epidemiologic studies suggest that Paget's disease is decreasing in prevalence and severity (implying that ...
Tim, Cundy, Ian R, Reid
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To review recent advance in understanding the causation and management of Paget's disease.We review recent publications concerning the aetiology of the disease and the use of biochemical markers of bone turnover in diagnosis and treatment.Epidemiologic studies suggest that Paget's disease is decreasing in prevalence and severity (implying that ...
Tim, Cundy, Ian R, Reid
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Calcified Tissue International, 1977
Paget’s disease of bone is a focal disorder of unknown etiology characterized initially by excessive resorption and subsequently by excessive formation of bone, culminating in a “mosaic” pattern of lamellar bone associated with extensive local vascularity and increased fibrous tissue in adjacent marrow.
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Paget’s disease of bone is a focal disorder of unknown etiology characterized initially by excessive resorption and subsequently by excessive formation of bone, culminating in a “mosaic” pattern of lamellar bone associated with extensive local vascularity and increased fibrous tissue in adjacent marrow.
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Current Osteoporosis Reports, 2017
Bone disease is a defining characteristic of multiple myeloma (MM) and the major cause of morbidity. It manifests as lytic lesions or osteopenia and is often associated with severe pain, pathological fracture, spinal cord compression, vertebral collapse, and hypercalcemia.
Cristina, Panaroni +2 more
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Bone disease is a defining characteristic of multiple myeloma (MM) and the major cause of morbidity. It manifests as lytic lesions or osteopenia and is often associated with severe pain, pathological fracture, spinal cord compression, vertebral collapse, and hypercalcemia.
Cristina, Panaroni +2 more
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Clinical Orthopaedics and Related Research, 1986
Caisson disease of bone, which may affect compressed air workers and divers, is characterized by regions of bone and marrow necrosis that may lead to secondary osteoarthrosis of the hip and shoulder joints. A review of the pathologic, radiologic, and clinical aspects demonstrated uncertainties in the exact etiology.
P J, Gregg, D N, Walder
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Caisson disease of bone, which may affect compressed air workers and divers, is characterized by regions of bone and marrow necrosis that may lead to secondary osteoarthrosis of the hip and shoulder joints. A review of the pathologic, radiologic, and clinical aspects demonstrated uncertainties in the exact etiology.
P J, Gregg, D N, Walder
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Best Practice & Research Clinical Haematology, 2004
The major clinical manifestation of multiple myeloma is related to the osteolytic bone destruction. The bone disease can lead to pathologic fractures, spinal cord compression, hypercalcemia, and pain. It is also a major cause of morbidity and mortality in these patients.
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The major clinical manifestation of multiple myeloma is related to the osteolytic bone destruction. The bone disease can lead to pathologic fractures, spinal cord compression, hypercalcemia, and pain. It is also a major cause of morbidity and mortality in these patients.
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DISEASES OF BONE AND DISEASES AFFECTING BONE
Veterinary Surgery, 1975SUMMARYDiseases of bones and diseases affecting bone are frequently related to breed, age, and limb involvement. The following checklist of diseases which may result in lameness are presented as a summation of the disease conditions likely to result in lameness in dog.
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Bone Marrow and Metabolic Bone Disease
Seminars in Musculoskeletal RadiologyAbstractThe bone marrow represents one of the largest organs in the body, with a relevant metabolic role that continues to be investigated. Numerous studies have focused on marrow adipose tissue (MAT). Evidence indicates that the bone marrow adipocytes do not only work as storage tissue but also consist of endocrine and paracrine cells, with the ...
Maria Pilar Aparisi Gómez +1 more
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Bone Quality in Paget’s Disease of Bone
Current Osteoporosis Reports, 2016Paget's disease of bone is produced by a localized increase in osteoclastic and osteoblastic activity which can progress slowly to involve an entire bone if untreated. A common feature is enlarged bones which are deformed, particularly in weight-bearing regions of the skeleton such as the lower extremity.
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Immunology and Allergy Clinics of North America, 2018
Systemic mastocytosis can give very different bone pictures: from osteosclerosis to osteoporosis. Osteoporosis is one of the most frequent manifestations particularly in adults and the most clinical relevant. It is often complicated by a high recurrence of mainly vertebral fragility fractures.
Orsolini, Giovanni +4 more
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Systemic mastocytosis can give very different bone pictures: from osteosclerosis to osteoporosis. Osteoporosis is one of the most frequent manifestations particularly in adults and the most clinical relevant. It is often complicated by a high recurrence of mainly vertebral fragility fractures.
Orsolini, Giovanni +4 more
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Orthopedic Clinics of North America, 1990
Paget's disease of bone is defined as a process of increased bone remodeling; the primary event is increased resorption (osteoclastic activity) followed by subsequent reactive bone formation (osteoblastic activity). It is usually asymmetric and may be asymptomatic.
R L, Merkow, J M, Lane
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Paget's disease of bone is defined as a process of increased bone remodeling; the primary event is increased resorption (osteoclastic activity) followed by subsequent reactive bone formation (osteoblastic activity). It is usually asymmetric and may be asymptomatic.
R L, Merkow, J M, Lane
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