Results 211 to 220 of about 283,173 (311)

Identifying Cytokine Motif‐Containing, Immunomodulatory Bacterial Proteins in Human Gut Microbiome

Advanced Science, EarlyView.
By building and constructing HMM (Upper left, blue), the authors identify CMCPs in bacteria genomes and CRC related metagenomes and enriched CRC‐related CMCPs (Upper right, blue). They analyze sequence and structural similarity of hits (Lower left, green), test function with engineered EcN delivered to tumors in a mouse tumor model (Lower right, pink ...
Ziyu Wang, Siqi Guo, Jing Li, Qianqian Huang, Jing Ning, Binbin Xia, Xun Lv, Xiang Liu, Zeyu Gao, Jine Li, Longchao Liu, Moshi Song, Jun Wang   +12 more
wiley   +1 more source

Modeling the chondrocyte-derived osteoblasts formation process reveals its molecular signature and regulation network. [PDF]

Bone Res
Ruiz-Hernández R, Gay L, Moncho-Amor V, Martín P, Vergara-Arce JA, Di Blasio S, Snoeks T, Cossío U, Matheu A, Caffarel MM, Gerovska D, Araúzo-Bravo MJ, Vilas A, Prosper F, Moya S, Alonso-Alconada D, Alonso-Varona A, Nusspaumer G, Lopez-Rios J, Rizotti K, Lovell-Badge R, Bonnet D, Malanchi I, Abarrategi A.   +23 more
europepmc   +1 more source

A Keratinocyte‐Mast Cell NF‐κB2/CXCL2/IL‐6 Amplification Loop Enhances Cutaneous Antifungal Defense Against C. albicans

Advanced Science, EarlyView.
ABSTRACT Mast cells (MCs), key innate immune sentinels at the host–environment interface, serve as primary responders to invading pathogens. However, their specific contribution to host defense against cutaneous Candida albicans (C. albicans) infection and their synergy with other immune and non‐immune cells remain poorly understood. Here, we show that
Yan Yuan, Manyun Mao, Jiaan Zhang, Zhimin Duan, JiaNing Wang, Yujie Chen, Sihan Chen, Chuting Liang, Xvyue Zhou, Songmei Geng, Min Li, Xu Chen, Ni Lian   +12 more
wiley   +1 more source

Advancements in bone marrow biopsy: the role of omics and artificial intelligence in hematologic diagnostics. [PDF]

Front Med (Lausanne)
Alwahaibi M, Alwahaibi N.
europepmc   +1 more source

Secondary osteons scale allometrically in mammalian humerus and femur [PDF]

, 2017
Biewener AA, Currey JD, Falconer H, Giua S, Gray JE, Jowsey J, Kerbert C, Kleiman DG, Larramendi A, Linnaeus C, Martin RB, Peters W, Quekett JT, Ritvo H, Swartz SM, Tarach J   +15 more
core   +2 more sources

Macrophage Extracellular Traps in Immunity and Cancer

Advanced Science, EarlyView.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li, Eugenie Nepovimova, Adam Grundel, Lukas Peter, Qinghua Wu, Kamil Kuca   +5 more
wiley   +1 more source

Gallbladder osseous metaplasia mimicking a focal lesion on ultrasound: a case report of a rare benign condition. [PDF]

J Surg Case Rep
Alouani H, Nasri S, Safta AB, Trabelsi MM, Jerraya H, Nouira R.   +5 more
europepmc   +1 more source

AML‐Targeted Metal‐Polyphenol Nanoplatform Induces Ferroptosis‐ICD Cascade for Antitumor Immunity Boosting

Advanced Science, EarlyView.
Schematic illustration of the synthesis protocol for Fe‐SH@Fn, an AML‐targeted nanoplatform engineered to co‐deliver shikonin (SH) and Fe3+, synergistically boosting antitumor immunity via ferroptosis induction and immunogenic cell death (ICD). ABSTRACT Acute myeloid leukemia (AML) remains a therapeutic challenge due to its low immunogenicity and ...
Shangqin Yang, Jingxuan Wang, Kerong Tu, Xiaobing Huang, Liangliang Lv, Mingjie Peng, Qiqi Xu, Hongmei Liu, Qiang Sun, Lulu Cai   +9 more
wiley   +1 more source

Legumain Restrains Granuloma Formation by Inhibiting mTORC1/STAT1‐Mediated M1 Macrophage Polarization in Sarcoidosis

Advanced Science, EarlyView.
Legumain (LGMN) is upregulated in macrophages during sarcoid‑like granuloma formation. Macrophage‑derived LGMN binds to integrin αvβ3 and suppresses mTORC1/STAT1 signaling to restrain M1 macrophage polarization. Intratracheal delivery of lipid nanoparticles carrying Lgmn plasmid DNA (pDNA) elevates LGMN expression and effectively attenuates pulmonary ...
Mengyuan Liu, Yueyin Han, Bingbing Xie, Lili Zhu, Wenxiu Xu, Yinzhen Han, Yue Liao, Shuwei Gao, Dingyuan Jiang, Jing Geng, Zhen Li, Yinan Hu, Huaping Dai   +12 more
wiley   +1 more source

The scientific basis of vascularized bone grafts: Models and perfusion assessments, a systematic review. [PDF]

JPRAS Open
Wölffer M, Olariu R, Woollard A, Zubler C.   +3 more
europepmc   +1 more source