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Skull and vertebral bone marrow are myeloid cell reservoirs for the meninges and CNS parenchyma
Science, 2021 Getting around the blood–brain barrier The meninges comprise three membranes that surround and protect the central nervous system (CNS). Recent studies have noted the existence of myeloid cells resident there, but little is known about their ontogeny and
A. Cugurra +16 more
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eLife, 2020 Bone marrow mesenchymal lineage cells are a heterogeneous cell population involved in bone homeostasis and diseases such as osteoporosis. While it is long postulated that they originate from mesenchymal stem cells, the true identity of progenitors and ...
L. Zhong +21 more
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Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET
Nature Network Boston, 2012 Tumor-derived exosomes are emerging mediators of tumorigenesis. We explored the function of melanoma-derived exosomes in the formation of primary tumors and metastases in mice and human subjects.
H. Peinado +24 more
semanticscholar +1 more source
Journal of Experimental Medicine, 1992 Antigen-presenting, major histocompatibility complex (MHC) class II- rich dendritic cells are known to arise from bone marrow. However, marrow lacks mature dendritic cells, and substantial numbers of proliferating less-mature cells have yet to be ...
K. Inaba +7 more
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Bone Vasculature and Bone Marrow Vascular Niches in Health and Disease
Journal of Bone and Mineral Research, 2020 Bone vasculature and bone marrow vascular niches supply oxygen, nutrients, and secrete angiocrine factors required for the survival, maintenance, and self‐renewal of stem and progenitor cells.
Junyu Chen +4 more
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Nature Cell Biology, 2019 The bone marrow constitutes the primary site for life-long blood production and skeletal regeneration. However, its cellular and spatial organization remains controversial.
Chiara Baccin +9 more
semanticscholar +1 more source
Sequestration of T-cells in bone marrow in the setting of glioblastoma and other intracranial tumors
Nature Network Boston, 2018 T cell dysfunction contributes to tumor immune escape in patients with cancer and is particularly severe amidst glioblastoma (GBM). Among other defects, T cell lymphopenia is characteristic, yet often attributed to treatment.
Pakawat Chongsathidkiet +22 more
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Nature Neuroscience, 2018 Innate immune cells recruited to inflammatory sites have short life spans and originate from the marrow, which is distributed throughout the long and flat bones.
F. Herisson +14 more
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Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Adrenergic nerve degeneration in bone marrow drives aging of the hematopoietic stem cell niche
Nature Network Boston, 2018 Aging of hematopoietic stem cells (HSCs) is associated with a decline in their regenerative capacity and multilineage differentiation potential, contributing to the development of blood disorders.
Maria Maryanovich +11 more
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