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Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

open access: yesNature Medicine, 2012
Tumor-derived exosomes are emerging mediators of tumorigenesis. We explored the function of melanoma-derived exosomes in the formation of primary tumors and metastases in mice and human subjects.
Héctor Peinado   +2 more
exaly   +2 more sources

Deep imaging of bone marrow shows non-dividing stem cells are mainly perisinusoidal

open access: yesNature, 2015
Haematopoietic stem cells (HSCs) reside in a perivascular niche but the specific location of this niche remains controversial. HSCs are rare and few can be found in thin tissue sections or upon live imaging, making it difficult to comprehensively ...
Malea M Murphy   +2 more
exaly   +2 more sources

Bone marrow adipocytes [PDF]

open access: yesAdipocyte, 2017
Adipocytes were identified in human bone marrow more than a century ago, yet until recently little has been known about their origin, development, function or interactions with other cells in the bone marrow. Little functional significance has been attributed to these cells, a paradigm that still persists today. However, we now know that marrow adipose
Gene P Ables   +10 more
openaire   +4 more sources

Mesenchymal and haematopoietic stem cells form a unique bone marrow niche

open access: yesNature, 2010
Simón Méndez-ferrer   +2 more
exaly   +2 more sources

Skull and vertebral bone marrow are myeloid cell reservoirs for the meninges and CNS parenchyma

open access: yesScience, 2021
Getting around the blood–brain barrier The meninges comprise three membranes that surround and protect the central nervous system (CNS). Recent studies have noted the existence of myeloid cells resident there, but little is known about their ontogeny and
A. Cugurra   +16 more
semanticscholar   +1 more source

Case report: A novel mutation in RTEL1 gene in dyskeratosis congenita

open access: yesFrontiers in Oncology, 2023
Dyskeratosis congenita (DKC), also known as Zinsser–Cole–Engman syndrome, is a telomeropathy typically presenting as a triad of leukoplakia, nail dystrophy, and reticular hyperpigmentation.
Haider Nisar   +5 more
doaj   +1 more source

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