Results 81 to 90 of about 1,134,898 (249)

Single- Versus Multiple-Site Harvesting Techniques for Bone Marrow Concentrate: Evaluation of Aspirate Quality and Pain

Orthopaedic Journal of Sports Medicine, 2017
Background: Bone marrow concentrate (BMC) is growing in popularity as an alternative treatment option in orthopaedics. The regenerative capacity of BMC has been linked to the number of mesenchymal stem cells (MSCs) present in the graft at the time of its
Kristin Oliver MD, MPH, Tariq Awan MD, Matthew Bayes MD   +2 more
doaj   +1 more source

In Vivo CRISPR Screen Identifies RPS19 as an Immunotherapy Target in Hepatocellular Carcinoma

Advanced Science, EarlyView.
By employing in vivo CRISPR functional screening, we identify ribosomal protein RPS19 as a pivotal mediator driving immune evasion in hepatocellular carcinoma, wherein tumor‑released RPS19 binds C5aR1 on tumor‑associated macrophages to initiate downstream immunosuppressive signaling; SP94‑peptide‑modified SNPSS nanoparticles deliver Cas9/sgRPS19 ...
Lei He, Duo Yu, Fei Xie, Kaisheng Hou, Zhaozhao Li, Meifang Dai, Jingyi Yun, Haiyan Cao, Yang Xiao, Yueyuan Qiu, Gege Shi, Wangqian Zhang, Shuning Wang, Qiang Hao, Jieyu Zhang, Zhaowei Wang, Yingqi Zhang, Kuo Zhang, Jintao Gu, Haichen Du, Meng Li   +20 more
wiley   +1 more source

Foamy histiocytes in a patient with visceral leishmaniasis after treatment with liposomal amphotericin B

The Turkish Journal of Pediatrics, 2008
A seven-year-old patient was admitted to our hospital with the complaints of fever, malaise, and abdominal distention. In the bone marrow aspiration smears, leishmania amastigotes were observed.
Betül Tavil, Gülten Seçmeer, Hasan Ozen, Ali Bülent Cengiz, Sule Unal, Aytemiz Gürgey   +5 more
doaj  

Assessment of dysplastic hematopoiesis: lessons from healthy bone marrow donors

Haematologica, 2012
Background According to WHO 2008 guidelines, the required percentage of cells manifesting dysplasia in the bone marrow to qualify as significant is 10% or over in one or more hematopoietic cell lineages, but this threshold is controversial.
Stefani Parmentier, Johannes Schetelig, Kerstin Lorenz, Michael Kramer, Robin Ireland, Ulrich Schuler, Rainer Ordemann, Gabi Rall, Markus Schaich, Martin Bornhäuser, Gerhard Ehninger, Frank Kroschinsky   +11 more
doaj   +1 more source

The Effect of Classical Turkish Music on Pain Severity and Anxiety Levels in Patients Undergoing Bone Marrow Aspiration and Biopsy

, 2019
Background: Bone marrow aspiration is a painful procedure. In addition, the anxiety experienced during the procedure can affect the pain felt during the procedure.
Sultan Taşcı, Yıldızhan, Esra, Ülkü Özdemir, Özdemir, Ülkü, Taşcı, Sultan, Eser, Bülent, Aslan, Suheyla, Esra Yıldızhan, Bülent Eser, Süheyla Aslan   +9 more
core   +1 more source

DUSP26 Regulated by YY1 Lactylation Couples Osteogenesis and Angiogenesis by Dephosphorylating PMPCB at Y141 and Activating Mitophagy in BMSCs

Advanced Science, EarlyView.
p300‐associated YY1 lactylation promotes DUSP26 expression in BMSCs. By regulating PMPCB phosphorylation and PINK1 processing, DUSP26 supports mitophagy, osteogenic differentiation, and pro‐angiogenic factor secretion. BMSC‐derived exosomes carrying a RUNX2 promoter‐driven DUSP26 plasmid favor osteogenic‐lineage transgene expression, partially ...
Yunpeng Lv, Feng Wu, Xiongjie Liang, Chong Liu, Wenhui Guo, Kejian Zhang, Jiawen Niu, Wenjie Jiang, Hongjian Xu, Anlong Jiang, Yang Zheng, Enming Yu, Xintao Wang, Jinglong Yan, Jingjun Xia, Chengchao Song   +15 more
wiley   +1 more source

EFFICACY OF DISPOSABLE SPINAL NEEDLE IN DIAGNOSTIC BONE MARROW ASPIRATION

Pakistan Armed Forces Medical Journal, 2012
Objective: To see the efficacy of disposable spinal needle in diagnostic bone marrow aspiration. Study Design: Observational study. Place and Duration of Study: Department of Haematology, Military Hospital and Army Medical College, Rawalpindi from 1st ...
Dr Nasira Shaheen, Zahra Rashid, Muhammad Qaiser Alam Khan, Waqar Azim   +3 more
doaj   +2 more sources

Study of bone marrow: dyserythropoiesis for etiological evaluation of anemia [PDF]

, 2017
Background: Bone Marrow Aspiration plays a major role in the diagnosis of various hematolgical disorders which are very frequent in various age groups. The aim of this study was to analyze the causes of haematological disorders, and to interpret the bone
Sheikh, Shamim, Parmar, Jignesh K.
core   +1 more source

Concurrent Germline RB1 & Mosaic TP53 in a Child With Multiple Childhood Cancers

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT We report a patient with a pathogenic germline variant (PGV) in RB1 and somatic mosaicism for a pathogenic TP53 variant who developed three distinct types of childhood cancer: retinoblastoma, osteosarcoma, and myelodysplastic syndrome (MDS) before the age of 6 years.
Ole Haubjerg Nielsen, Ulrik Kristoffer Stoltze, Pernille Axél Gregersen, Marianne Hoffmann, Morten Lyng Høgild, Mette Klarskov Andersen, Lise Barlebo Ahlborn, Lisa Lyngsie Hjalgrim, Karin A. W. Wadt   +8 more
wiley   +1 more source

Generation of osteoinductive grafts by three-dimensional perfusion culture of human bone marrow cells into porous ceramic scaffolds [PDF]

, 2005
The main aims of this thesis were (i) to identify and develop a system that could be reproducibly used to streamline manufacture of osteoinductive grafts based on human bone marrow stromal cells (BMSC) in the context of regenerative medicine, (ii) to ...
Braccini, Alessandra
core   +1 more source