Results 191 to 200 of about 548,525 (315)

Various roles of heme oxygenase-1 in response of bone marrow macrophages to RANKL and in the early stage of osteoclastogenesis [PDF]

, 2018
Bukowska-Straková, Karolina, Dulak, Józef, Florczyk-Soluch, Urszula, Józefczuk, Ewelina, Józkowicz, Alicja, Mendel, Mateusz, Nowak, Witold, Stępniewski, Jacek, Viscardi, Monika   +8 more
core   +1 more source

TRAP5 Inhibition Targeting Scar‐Associated Macrophages Ameliorates Acute Kidney Injury to Chronic Kidney Disease Transition

Advanced Science, EarlyView.
This study delineates macrophage heterogeneity along the acute kidney injury to chronic kidney disease transition. Single‐cell RNA sequencing reveals a TRAP5+ scar‐associated macrophage subset driven by Spp1–Cd44 signaling and mitochondrial metabolic reprogramming.
Chenxi Wang, Yaodong Gu, Wen Du, Lin Xie, Jinwei Quan, Yu Zhao, Ye Cheng, Zhaonan Wei, Yuanyuan Sha, Yi Wang, Dechao Xu, Xiang Gao, Min Chen, Xiangchen Gu   +13 more
wiley   +1 more source

Protective effect of pomegranate seed oil against lead acetate-induced toxicity on the hippocampus and bone marrow in rats. [PDF]

Avicenna J Phytomed
Alavi MS, Hosseini A, Torabi F, Rayati Banadkooki M, Taghadosi Z, Boroushaki MT.   +5 more
europepmc   +1 more source

A Photothermal Transducer Regulates Transmembrane Calcium Flow for Synergistic Osteoarthritis Therapy

Advanced Science, EarlyView.
Upon NIR irradiation at 808 nm, the activity of TRPV4 was inhibited by M2M@BPSC, which led to reduced calcium influx, mitochondrial protection, and, importantly, the transcriptional activation of the STAT6‐EGR2 pathway. The improved macrophage function indirectly readjusts the equilibrium between C‐ECM and F‐ECM to reconstruct a suitable ...
Chenqi Yu, Yang Liu, Kang Kang, Jianfeng Yu, Xiaowei Xia, Yaoge Deng, Yingjie Lu, Huilin Yang, Lisong Li, Wu Xu, Yijian Zhang, Xuesong Zhu   +11 more
wiley   +1 more source

The Art of Deception: Multiple Myeloma Imitating Spondyloarthritis-A Case Report. [PDF]

Clin Case Rep
Khatri P, Subedi A, Dahal B, Shrestha G, Phuyal M, Adhikari R.   +5 more
europepmc   +1 more source

Identifying Cytokine Motif‐Containing, Immunomodulatory Bacterial Proteins in Human Gut Microbiome

Advanced Science, EarlyView.
By building and constructing HMM (Upper left, blue), the authors identify CMCPs in bacteria genomes and CRC related metagenomes and enriched CRC‐related CMCPs (Upper right, blue). They analyze sequence and structural similarity of hits (Lower left, green), test function with engineered EcN delivered to tumors in a mouse tumor model (Lower right, pink ...
Ziyu Wang, Siqi Guo, Jing Li, Qianqian Huang, Jing Ning, Binbin Xia, Xun Lv, Xiang Liu, Zeyu Gao, Jine Li, Longchao Liu, Moshi Song, Jun Wang   +12 more
wiley   +1 more source

Epigenetic transcriptional regulation of skeletal aging: The emerging role of m⁶A methylation. [PDF]

J Orthop Translat
Song C, Song G, Zhang S, Zhao H, Wen Z, Chen Y, Chen X, Liu B, Ni Q, Fan D.   +9 more
europepmc   +1 more source

A Keratinocyte‐Mast Cell NF‐κB2/CXCL2/IL‐6 Amplification Loop Enhances Cutaneous Antifungal Defense Against C. albicans

Advanced Science, EarlyView.
ABSTRACT Mast cells (MCs), key innate immune sentinels at the host–environment interface, serve as primary responders to invading pathogens. However, their specific contribution to host defense against cutaneous Candida albicans (C. albicans) infection and their synergy with other immune and non‐immune cells remain poorly understood. Here, we show that
Yan Yuan, Manyun Mao, Jiaan Zhang, Zhimin Duan, JiaNing Wang, Yujie Chen, Sihan Chen, Chuting Liang, Xvyue Zhou, Songmei Geng, Min Li, Xu Chen, Ni Lian   +12 more
wiley   +1 more source

Rare presentation of Pre-B acute lymphoblastic leukemia with severe eosinophilia, bicytopenia, and cardiac mass in a 4-year-old boy: a case report. [PDF]

BMC Pediatr
Hayatbakhsh E, Karami Robati F, Nasri A, Jafari E, Lashkarizadeh M.   +4 more
europepmc   +1 more source

Macrophage Extracellular Traps in Immunity and Cancer

Advanced Science, EarlyView.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li, Eugenie Nepovimova, Adam Grundel, Lukas Peter, Qinghua Wu, Kamil Kuca   +5 more
wiley   +1 more source