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The bone marrow in Hodgkin's disease: the non‐involved marrow
Histopathology, 1978One hundred and nineteen methacrylate‐embedded trephine biopsy specimens from 80 patients with Hodgkin's disease are reviewed. Although marrow involvement was found in 4% of the untreated patients, the present study was mainly concerned with the marrow unaffected by specific infiltrates and in negative specimens. The non‐involved bone marrow in Hodgkin'
J, Te Velde +4 more
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Bone Marrow and Metabolic Bone Disease
Seminars in Musculoskeletal RadiologyAbstractThe bone marrow represents one of the largest organs in the body, with a relevant metabolic role that continues to be investigated. Numerous studies have focused on marrow adipose tissue (MAT). Evidence indicates that the bone marrow adipocytes do not only work as storage tissue but also consist of endocrine and paracrine cells, with the ...
Maria Pilar Aparisi Gómez +1 more
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Histiocytic Diseases of Bone Marrow
Hematology/Oncology Clinics of North America, 1988The disease most likely to be associated with large numbers of bone marrow storage histiocytes is Gaucher's disease. In our community of western Pennsylvania, eastern Ohio, and West Virginia, we have encountered 30 patients with Gaucher's disease during the past 25 years.
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Bone Marrow Transplantation for Genetic Diseases
Hematology/Oncology Clinics of North America, 1990Bone marrow transplantation is the treatment of choice for a number of genetic diseases. Recently, bone marrow transplantation has been increasingly used for erythroid disorders, such as thalassemia and sickle cell anemia. A number of inherited metabolic disorders (i.e., storage diseases, leukodystrophies, and the like) may be corrected with a marrow ...
C, Lenarsky +3 more
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Multiple myeloma—A painful disease of the bone marrow
Seminars in Cell & Developmental Biology, 2021Multiple myeloma is a bone marrow neoplasia with an incidence of 6/100,000/year in Europe. While the disease remains incurable, the development of novel treatments such as autologous stem cell transplantation, proteasome inhibitors and monoclonal antibodies has led to an increasing subset of patients living with long-term myeloma.
Diaz-delcastillo, Marta +3 more
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2019
The bone marrow consists of active red marrow and inactive fatty marrow which is mainly situated in the extremities. Red marrow can be replaced by various conditions. Focal disease is easy to perceive; however, diffuse disease is often hard to detect. Gadolinium application can help for quantification of contrast enhancement.
Andrea Baur-Melnyk, Tobias Geith
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The bone marrow consists of active red marrow and inactive fatty marrow which is mainly situated in the extremities. Red marrow can be replaced by various conditions. Focal disease is easy to perceive; however, diffuse disease is often hard to detect. Gadolinium application can help for quantification of contrast enhancement.
Andrea Baur-Melnyk, Tobias Geith
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Bone marrow biopsy in malignant disease
Postgraduate Medicine, 1974Bone marrow examination should routinely include biopsy. Often it is the only means of detecting advanced malignant disease. The findings aid in determining therapy and sometimes in following therapeutic response.
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Bone Marrow Transplantation for Genetic Diseases
New England Journal of Medicine, 1987Four recent editorials in the Journal have reviewed the potential for increasing the therapeutic armamentarium for genetic disease.1 2 3 4 Bone marrow transplantation has been considered in each of...
W, Krivit, C B, Whitley
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Impact of bone marrow on respiratory disease
Current Opinion in Pharmacology, 2008The bone marrow is not only a site of haematopoiesis but also serves as an important reservoir for mature granulocytes and stem cells, including haematopoietic stem cells, mesenchymal stem cells and fibrocytes. In respiratory diseases, such as asthma and idiopathic pulmonary fibrosis these cells are mobilised from the bone marrow in response to blood ...
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Bone Marrow Transplantation for Nonmalignant Diseases
Journal of Hematotherapy & Stem Cell Research, 2002Bone marrow transplantation (BMT) has emerged as a major therapeutic option for a number of nonmalignant disorders affecting the bone marrow and leading to clinical manifestations most likely affecting distant organs. Disorders such as autoimmune diseases, metabolic disorders, hemoglobinopathies, immunodeficiencies, and others have been the target of ...
Nabil, Saba, Thomas, Flaig
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