Results 41 to 50 of about 181,318 (257)

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

Yield of Bone Marrow Examination in Diagnosis of HIV Infected Patients with Fever of Unknown Origin

Siriraj Medical Journal, 2014
Background:  HIV-infected patients are commonly found with fever of unknown origin (FUO), leading to high morbidity, prolonged hospitalization, and extensive diagnosis.
Patama Suttha
doaj  

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

Bone Marrow Aspirate – A Diagnostic Tool in Hematology, Importance, and Applications: Experience from Jordanian Royal Medical Services

Journal of Applied Hematology
BACKGROUND: A bone marrow aspirate is a medical procedure used to extract a small amount of bone marrow fluid and cells for examination under microscope. It is a very useful diagnostic tool in hematological field.
Mohammad J. Maaita, Abdullah Alshawabkeh, Manar AlJaafreh, Talal Mwafaq, Mohammad N. Almanaseer, Saif N. Alshoubaki, Elham A. Alsmadi   +6 more
doaj   +1 more source

Bone marrow aspiration and biopsy. Technique and considerations

Revista Médica del Hospital General de México, 2015
Bone marrow aspiration and bone marrow biopsy are invasive procedures in which good technical skill is crucial to obtain samples suitable for processing and diagnostic interpretation. The type and calibre of the needle is one of the main variables of the
R.A. Trejo-Ayala, M. Luna-Pérez, M. Gutiérrez-Romero, J. Collazo-Jaloma, M.C. Cedillo-Pérez, C.O. Ramos-Peñafiel   +5 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Diagnostic insights into disseminated histoplasmosis: a case report highlighting bone marrow analysis

Iranian Journal of Microbiology
We present a case of a 43-year-old immunocompromised female patient diagnosed with disseminated histoplasmosis on bone marrow examination, at clinical laboratory of Kasturba Hospital, Manipal, Karnataka, India. The patient, presenting with symptoms like
Vaanya Kaushik, Ruchee Khanna, Vinay Khanna, Muralidhar Varma   +3 more
doaj   +1 more source

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin, Binbin Xue, Dewei Xie, Jia Li, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Ruofan Zhu, Xu Zhang, Junhui Xia, Xiang Li   +11 more
wiley   +1 more source

Evaluation the Role of Bone Marrow Examination in Diagnosis of Hematological Diseases in Hemato-Oncology Centers in Kurdistan

Iraqi Journal of Hematology, 2016
Background: Bone marrow aspiration and trephine biopsy have an important role in evaluation and diagnosis of most hematological and some non hematological disorders.
Shorsh Jameel Ridha, Nawsherwan Sadiq Mohammad, Hoger Ismael Muhammed Sarhang   +2 more
doaj