Results 31 to 40 of about 356,556 (259)

Haploidentical transplants deliver equal outcomes to matched sibling transplants: a propensity score-matched analysis

Journal of Translational Medicine, 2023
The success of allogeneic hematopoietic stem cell transplant for hematological malignancies is heavily dependent on the availability of suitable donors. Haploidentical donor (HID) and matched sibling donor (MSD) are two important donor options providing ...
Hengwei Wu, Yeqian Zhao, Fei Gao, Jimin Shi, Yi Luo, Jian Yu, Xiaoyu Lai, Lizhen Liu, Huarui Fu, Pengxu Qian, He Huang, Yanmin Zhao   +11 more
doaj   +1 more source

Watch and Wait – Actualities in the Treatment of Chronic Lymphocytic Leukemia

Journal of Interdisciplinary Medicine, 2017
In Western countries, chronic lymphocytic leukemia (CLL) is one of the most diagnosed leukemia types among elderly patients. CLL is described as an indolent lymphoproliferative disorder, characterized by the presence of a high number of small, mature B ...
Bíró Szilárd, Benedek István, Bzduch Árpád, Sándor-Kéri Johanna, Lázár Erzsébet, Benedek István   +5 more
doaj   +1 more source

Immunomagnetic t-lymphocyte depletion (ITLD) of rat bone marrow using OX-19 monoclonal antibody [PDF]

, 1989
Graft versus host disease (GVHD) may be abrogated and host survival prolonged by in vitro depletion of T lymphocytes from bone marrow (BM) prior to allotransplantation. Using a mouse anti-rat pan T-lymphocyte monoclonal antibody (0×19) bound to monosized,
A. Pascualone, A.L. Hoffman, B.F. Banner, Barclay A, Berenson R J, Beschorner W E, Bril H, D.G. Sheahan, D.V. Cramer, Dallman M J, Elkins W L, Farnsworth A, Filipovich A H, Kvalheim G, L. Makowka, Lubaroff D M, Martin P J, Monchik G J, Oaks M K, P. Rettinger, Prentice H G, Reisner Y, Rodt H, Slavin R E, T.E. Starzl, Thtschka P J, Tsoi M-S, Van Bekkum D W, Vartdal F, Waldman H, X. Cai   +30 more
core   +1 more source

Unrelated Allogeneic Stem Cell Transplantation in a Patient with Chronic Myeloid Leukemia in Blast Crisis

Journal of Interdisciplinary Medicine, 2017
Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder, which can involve the hematopoietic stem cell or early progenitor cells, without the loss of their capacity to differentiate.
Benedek István, Lázár Erzsébet, Köpeczi Judit Beáta, Benedek István, Tunyogi Aliz Beáta, Jakab Szende, Pakucs Annamária   +6 more
doaj   +1 more source

The oncometabolite R-2-hydroxyglutarate dysregulates the differentiation of human mesenchymal stromal cells via inducing DNA hypermethylation

BMC Cancer, 2021
Background Isocitrate dehydrogenase (IDH1/2) gene mutations are the most frequently observed mutations in cartilaginous tumors. The mutant IDH causes elevation in the levels of R-enantiomer of 2-hydroxylglutarate (R-2HG). Mesenchymal stromal cells (MSCs)
Lizhen Liu, Kaimin Hu, Jingjing Feng, Huafang Wang, Shan Fu, Binsheng Wang, Limengmeng Wang, Yulin Xu, Xiaohong Yu, He Huang   +9 more
doaj   +1 more source

Leukemia with Plasma Cells — Case Report

Journal of Interdisciplinary Medicine, 2017
Plasma cell leukemia (PCL) is one of the most aggressive monoclonal gammopathies, being characterized by the presence of more than 20% of plasma cells in the peripheral blood and an absolute number of these cells of more than 2×109, with different ...
Benedek István, Benedek István, Köpeczi Judit Beáta, Kéri Johanna Sándor, Pakucs Annamária, Jakab Szende, Lázár Erzsébet   +6 more
doaj   +1 more source

Metabolic reprogramming in macrophage responses

Biomarker Research, 2021
Macrophages are critical mediators of tissue homeostasis, with the function of tissue development and repair, but also in defense against pathogens. Tumor-associated macrophages (TAMs) are considered as the main component in the tumor microenvironment ...
Yang Liu, Ruyi Xu, Huiyao Gu, Enfan Zhang, Jianwei Qu, Wen Cao, Xi Huang, Haimeng Yan, Jingsong He, Zhen Cai   +9 more
doaj   +1 more source

Dengue virus infection in hematopoietic stem cell transplant recipients: A case series and comparative literature review from dengue endemic region

SAGE Open Medical Case Reports
This case series describes the wide spectrum of clinical presentation, laboratory findings, and morbidity/mortality associated with dengue fever in hematopoietic stem cell transplant recipients, treated in a dengue endemic region.
Waseem Shahani, Faiqa Fayyaz, Shafaq Abdul Samad, Muhammad Nizamuddin, Madiha Abid, Aisha Jamal, Zainab Ghayas, Ayesha Rafiq, Abdul Hayee, Dilnasheen Safdar, Tasleem Farzana, Uzma Zaidi   +11 more
doaj   +1 more source

Immune Reconstitution-Based Score for Risk Stratification of Chronic Graft-Versus-Host Disease Patients

Frontiers in Oncology, 2021
IntroductionAllogeneic stem cell transplantation survivors are at a relevant risk of developing chronic GvHD (cGvHD), which importantly affects quality of life and increases morbidity and mortality.
Fabio Serpenti, Francesca Lorentino, Francesca Lorentino, Sarah Marktel, Raffaella Milani, Carlo Messina, Raffaella Greco, Stefania Girlanda, Daniela Clerici, Fabio Giglio, Carmine Liberatore, Francesca Farina, Sara Mastaglio, Simona Piemontese, Elena Guggiari, Francesca Lunghi, Magda Marcatti, Matteo G. Carrabba, Massimo Bernardi, Chiara Bonini, Chiara Bonini, Andrea Assanelli, Consuelo Corti, Jacopo Peccatori, Fabio Ciceri, Fabio Ciceri, Maria Teresa Lupo-Stanghellini   +26 more
doaj   +1 more source

Stem Cell Mobilization and Harvesting Failure in Case of Heavily Pretreated Patients

Journal of Interdisciplinary Medicine, 2017
Background: High-dose chemotherapy and autologous stem cell transplantation have become a standard curative treatment in various hematologic malignancies. Many factors can affect the success of mobilization and hematopoietic stem cell harvesting.
Mild Eszter, Lázár Erzsébet, Köpeczi Judit-Beáta, Kakucs Enikő, Găzdac Marius, Pakucs Annamária, Tudor Cezara, Benedek István   +7 more
doaj   +1 more source