Results 51 to 60 of about 239,349 (307)

Allogeneic bone marrow transplantation for infants with acute leukemia or myelodysplastic syndrome

, 2001
The objective of this study is to investigate the outcome of children 24 months or age or younger (infants) at the time of allogeneic bone marrow transplantation (BMT) for acute leukemia or myelodysplasia.
Cunningham, J. M., Pitts, N., Leung, W., Woodard, P., Bowman, L. C., Benaim, E., Horwitz, E. M., Burnette, K., Pui, C. H., Hale, G.   +9 more
core   +1 more source

NUDT21 Drives T‐Cell Acute Lymphoblastic Leukemia Through Dual Regulation of Alternative Polyadenylation and Transcriptional Activation

Advanced Science, EarlyView.
In summary, our study defines a coordinated oncogenic model in which NUDT21 integrates alternative polyadenylation–dependent UBE2D3 stabilization and transcriptional activation to sustain MYC‐driven T‐ALL cell survival, thereby establishing NUDT21 as a central regulatory node and a promising therapeutic target.
Conglian Qiu, Jianwei Wang, Zhiheng Li, Qi Ji, Hui Zhang, Qinyi Zhang, Senlin Zhang, Juanjuan Yu, Yanfang Tao, Yijun Wu, Chunxia Shi, Zong Zai, Zimu Zhang, Yizhen Li, Zhenjiang Bai, Shaoyan Hu, Jian Pan, Yang Yang, Shuiyan Wu   +18 more
wiley   +1 more source

Bone Marrow Transplantation in Leukemia

, 1983
Marrow grafting is now an established treatment for patients under the age of 50 with acute leukemia and a suitable marrow donor. For all patients who have relapsed at least once, marrow grafting offers the possibility of cure of approximately 20%-30% of these patients, which cannot be achieved by any other regimen yet reported. Although still somewhat
openaire   +3 more sources

Bone marrow transplantation for thalassaemia [PDF]

Journal of Internal Medicine, 1997
For all patients with a histocompatibiliy antigen (HLA) identical donor we are actually using two protocols to whom the patient is assigned. This is based on which class the patients belongs to at the time of bone‐marrow transplant and is independent from the patient's age.
openaire   +2 more sources

Noninvasive in vivo tracking of mesenchymal stem cells and evaluation of cell therapeutic effects in a murine model using a clinical 3.0 T MRI

, 2013
Cardiac cell therapy with mesenchymal stem cells (MSCs) represents a promising treatment approach for end-stage heart failure. However, little is known about the underlying mechanisms and the fate of the transplanted cells. The objective of the presented
Neef, Klaus, Drey, Florian, Choi, Yeong-Hoon, Brenkmann, Meike, Tenbrock, Arne, Wahlers, Thorsten, Treskes, Philipp, Wittwer, Thorsten, Liakopoulos, Oliver J, Ewert, Birgit, Bovenschulte, Henning, Stamm, Christof   +11 more
core   +1 more source

Extracellular Vesicle‐Transferred ATP‐Citrate Lyase Induces Monocyte Differentiation Toward Tumor‐Associated Macrophages and Fuels Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Hepatocellular carcinoma (HCC)‐derived extracellular vesicles (EVs) enrich the metabolic enzyme ATP‐citrate lyase (ACLY). EV‐transferred ACLY enhances palmitate biosynthesis, increases the S‐palmitoylation and stability of multiple immune checkpoint proteins, augments the cellular immunosuppressive activity, and ultimately accelerates the malignant ...
Zhijun Liu, Haihong Lai, Qing Yang, Chaoyue Zhang, Bin Jia, Qiyi Chen, Yuling Deng, Fen Cao, Yuyu You, Zhe Li, Dongming Kuang, Bo Li   +11 more
wiley   +1 more source

Vogt-Koyangi-Harada syndrome complcating allogeneic bone marrow transplantation

, 1994
Vogt-Koyanagi-Harada (VKH) syndrome is an uncommon acute ophthalmological disorder, characterised by bilateral serous retinal detachment with diffuse choroiditis, in association with specific extra-ocular manifestations.
Neoh, C, Pettitt, AR, Wong, SHD, Clark, RE   +3 more
core  

Editorial: Bone marrow transplants in leukemia. [PDF]

, 1974

openalex   +1 more source

Tumor‐Derived Exosomes Deliver Membrane‐Bound Fgl2 to Activate FcγRIIB‐Mediated Immunosuppression in Myeloid‐Derived Suppressor Cells

Advanced Science, EarlyView.
This study reveals that the Fgl2‐FcγRIIB signaling axis is a key mechanism by which MDSCs mediate tumor immune evasion. Tumor‐derived exosomes systemically activate MDSCs via this pathway, positioning this axis as a promising broad‐spectrum target for cancer immunotherapy.
Fenglin Lin, Dingqin Cai, Chunli Jian, Yaxian Qi, Linpeng Zheng, Qiao Yang, Longyao Zhang, Diangang Chen, Lingchen Li, Ping Cai, Lingyou Sun, Luping Zhang, Jianguo Sun   +12 more
wiley   +1 more source

Oral cryotherapy to prevent total parenteral nutrition for patients undergoing bone marrow transplantation

, 2006
Introduction: Mucositis is a major complication in intensive chemotherapy, which often necessitates total parenteral nutrition (TPN). While the side effects of the conditioning regimes vary with regard to degree of severity among individual’s and between
Svanberg, Anncarin,, Birgegård, Gunnar, Öhrn, Kerstin,   +2 more
core