Results 61 to 70 of about 1,454,464 (291)

Association of Elevated Platelets and C‐Reactive Protein With Severe Disease and Poor Survival in Systemic Sclerosis

Arthritis Care &Research, EarlyView.
Objective Elevated C‐reactive protein (CRP) levels in systemic sclerosis (SSc) have been linked with severe disease and worse survival, but the role of platelet levels remains unclear. This study examined whether elevated platelet levels, CRP levels, or both are associated with disease severity, progression, and survival in SSc.
Brian S. Lee, Shufeng Li, Srijana Davuluri, Jennifer Lee, Lorinda Chung   +4 more
wiley   +1 more source

Making the Case for Organ‐on‐Chip Platforms in Long‐Acting Therapeutics Development

Advanced Healthcare Materials, EarlyView.
LATs release drug from a tissue‐resident depot over weeks to months, improving adherence, but their development is hampered by preclinical models that cannot reproduce the coupled tissue processes, sustained release, local microenvironment change, interstitial transport, immune and foreign‐body responses, and clearance that govern depot performance in ...
Charlie Gowans, Abdulwahhab Khedr, Panagiotis G. Georgiou, Nehir Arik, Ozlem Sen, Steve P. Rannard, Tom O. McDonald, Christos Tapeinos   +7 more
wiley   +1 more source

New Treatment Methods in Multiple Myeloma

Journal of Interdisciplinary Medicine, 2017
Multiple myeloma accounts for 10% of the hematologic malignancies and is characterized by a single clone of plasma cells producing a monoclonal protein. The aim of this review is to summarize the current treatment methods of multiple myeloma. In the last
Jakab Szende, Lázár Erzsébet, Benedek István, Köpeczi Judit Beáta, Pakucs Annamária, Benedek István   +5 more
doaj   +1 more source

mTOR inhibition improves the immunomodulatory properties of human bone marrow mesenchymal stem cells by inducing COX-2 and PGE2

Stem Cell Research & Therapy, 2017
Background Bone marrow mesenchymal stem cells (MSCs) are promising candidates for the treatment of various inflammatory disorders due to their profound immunomodulatory properties.
Binsheng Wang, Yu Lin, Yongxian Hu, Wei Shan, Senquan Liu, Yulin Xu, Hao Zhang, Shuyang Cai, Xiaohong Yu, Zhen Cai, He Huang   +10 more
doaj   +1 more source

Metabolic reprogramming in macrophage responses

Biomarker Research, 2021
Macrophages are critical mediators of tissue homeostasis, with the function of tissue development and repair, but also in defense against pathogens. Tumor-associated macrophages (TAMs) are considered as the main component in the tumor microenvironment ...
Yang Liu, Ruyi Xu, Huiyao Gu, Enfan Zhang, Jianwei Qu, Wen Cao, Xi Huang, Haimeng Yan, Jingsong He, Zhen Cai   +9 more
doaj   +1 more source

Clinical utilization of Chimeric Antigen Receptors T-cells (CAR-T) in B-cell acute lymphoblastic leukemia (ALL) - an expert opinion from the European Society for Blood and Marrow Transplantation (EBMT) and the American Society for Blood and Marrow Transplantation (ASBMT). [PDF]

, 2018
On August 30, 2017, the U.S. Food and Drug Administration (US-FDA) approved tisagenlecleucel (KYMRIAH, Novartis, Basel, Switzerland), a synthetic bioimmune product of anti-CD19 chimeric antigen receptor-T cells (CAR-T), for the treatment of children and ...
Liu, Hien D, Aljurf, Mahmoud Deeb, Litzow, Mark R., Litzow, Mark Robert, Carpenter, Paul A, Kansagra, Ankit J., Carpenter, Paul A., Savani, Bipin N., Frey, Noelle V, Komanduri, Krishna V, Kharfan-Dabaja, M. A., Perales, Miguel A, Kharfan-Dabaja, Mohamed A., Johnston, Laura, Gastineau, Dennis A., Johnston, Laura J., Bazarbachi, Ali, Grupp, Stephan A., Bar, Merav, Bollard, Catherine M., Bonini, Chiara, Mufti, Ghulam J., Kebriaei, Partow, Heslop, Helen E, Shah, Nirali N, Kenderian, Saad, Shah, Nirali N., Ghobadi, Armin, Bachanova, Veronika, Jacoby, Elad, Kansagra, Ankit J, Hashmi, Shahrukh K., Kharfan-Dabaja, Mohamed A, Barrett, John A., Grupp, Stephan A, Gastineau, Dennis A, Pavletic, Steven Z., Kenderian, Saad Sirop Irop, Laetsch, Theodore W., Chabannon, Christian, Mohty, Mohamad, Mufti, Ghulam J, Gill, Saar I., Bollard, Catherine M, Bachanova, V., Hill, Joshua A., Shpall, Elizabeth J, Barrett, John A, Perales, Miguel A., Aljurf, Mahmoud, Shpall, Elizabeth J., Maloney, David G., Andritsos, Leslie, Nagler, Arnon, DiPersio, John F., Perales, Miguel Ángel, Laetsch, Theodore W, DiPersio, John F, Hashmi, Shahrukh K, Laetsch, Theodore Willis, Hudecek, Michael, Porter, David L., Heslop, Helen E., Savani, Bipin N, Frey, Noelle V., Komanduri, Krishna V., Liu, Hien D., Hill, Joshua, Hill, Joshua A, Pavletic, Steven Z, Bazarbachi, Ali Abdul Hamid, Gill, Saar I, Porter, David L, Pavletic, Zivko Steven, Sadelain, Michel W.J., Hashmi, Shahrukh Khurshid, Maloney, David, Andritsos, Leslie A., Litzow, Mark R, Sadelain, Michel   +79 more
core   +1 more source

Bioengineered Interfaces for Peripheral Nerve Sensory Restoration

Advanced Materials, EarlyView.
Half of amputees abandon their prosthetics for lack of feeling. This review charts the full path from peripheral nerve injury to restored sensation, through surgical, regenerative, noninvasive, and implanted approaches, and shows how injury type and interface material properties determine which strategy can deliver naturalistic feedback, and why ...
Sydney Swedick, Salim El Hadwe, Kesi Liang, George G. Malliaras, Damiano G. Barone   +4 more
wiley   +1 more source

Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties

Advanced Science, EarlyView.
Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez, Rose E. Presby, Sara Nakanishi, Pallavi Gaur, Ugur Akcan, Johannes Daugaard Krog, Iben Daugaard Krog, Lipi Das, David S. Johnson, Danny Jamoul, Douglas Jury, Brian Lawson, Jacob Körbelin, Lewis M. Brown, Vilas Menon, Dritan Agalliu, Irene Munk Pedersen   +16 more
wiley   +1 more source

Long-term effects of autologous bone marrow stem cell treatment in acute myocardial infarction: factors that may influence outcomes [PDF]

, 2012
AIMS: To investigate whether there are important sources of heterogeneity between the findings of different clinical trials which administer autologous stem cell treatment for acute myocardial infarction (AMI) and to evaluate what factors may influence ...
Anthony Mathur, Fisher Sheila A., Doree Carolyn, Doree, C, Mike J Clarke, Carolyn Doree (162145), Enca Martin-Rendon, Mathur Anthony, Clarke, MJ, Martin-Rendon Enca, Susan J Brunskill, Brunskill, Susan J., Susan J. Brunskill (162133), Watt, SM, Sheila A. Fisher (162124), Clifford, DM, Mike J. Clarke (162164), Watt Suzanne M., Carolyn Doree, Clifford, David M., Fisher, Sheila A., Brunskill, SJ, Suzanne M Watt, David M. Clifford (162115), Martin-Rendon, E, David M Clifford, Watt, Suzanne M., Brunskill Susan J., Clifford David M., Enca Martin-Rendon (162178), Suzanne M. Watt (162171), Fisher, SA, Doree, Caroyln, Mathur, Anthony, Clarke Mike J., Clarke, Michael, Anthony Mathur (162155), Sheila A Fisher, Martin-Rendon, Enca, Mathur, A   +39 more
core   +2 more sources

Mr BMT Achieves Systemic Macrophage Replacement With Preservation of Tissue Homeostasis

Advanced Science, EarlyView.
Microglia replacement by bone marrow transplantation (Mr BMT) enables systemic replacement of tissue‐resident macrophages. Despite persistent macrophage and tissue remodeling across multiple organs, core biological functions and innate immune responses remain preserved, supporting long‐term maintenance of organismal homeostasis and the therapeutic ...
Yufei Xu, Miaozhan Zou, Yunshang Bai, Yang He, Zhihao Jin, Baozhi Yang, Jinjin Du, Pei Ouyang, Yuanyuan Cai, Yuheng Zhang, Bingying Du, Chengcheng Ge, Jian‐an Gong, Xiaoyu Li, Yuanyi Zheng, Jing Ding, Bo Peng, Yanxia Rao   +17 more
wiley   +1 more source