Results 71 to 80 of about 239,349 (307)
Advanced Science, EarlyView.After spinal cord injury, adult microglia remain persistently activated with chronic PRMT6 (protein arginine methyltransferase 6) upregulation. Prmt6 deficiency or inhibition reestablishes microglial homeostasis and promotes a scar‐limited repairment, enhancing axonal regrowth.
Weilin Peng +9 more
wiley +1 more source
Autologous transplantation of bone marrow mononuclear stem cells by mini-thoracotomy in dilated cardiomyopathy: technique and early results [PDF]
, 2008 Renato A. K. Kalil +9 more
openalex +1 more source
Advanced Science, EarlyView.TAX2‐NPs capture extracellular TSP‐1 in the injured liver and promote its macrophage‐mediated autophagic degradation. This process blocks TSP‐1/CD47 signaling, restores VEGFR2‐AKT activity, preserves endothelial function, and mitigates hepatic ischemia‐reperfusion injury.
Haorui Wang +12 more
wiley +1 more source
Advanced Science, EarlyView.Light‐switchable MSCs (MSC‐UCNPs) were constructed by intracellular incorporation of UCNPs. Upon 980 nm irradiation, UCNPs emitted localized ultraviolet light (365 nm), activating the ROS/HEXB/LAMP1 signaling pathway to suppress lysosome–multivesicular body fusion and thereby enhance exosome biogenesis. Embedded within an injectable hydrogel, MSC‐UCNPs
Tingting Wu +7 more
wiley +1 more source
The role of bone marrow derived cells in cardiac repair
, 2012 PhDCurrent pharmacological therapies fail to address the final end-point of cardiac ischaemia — the death and dysfunction of cardiomyocytes. Advances in stem cell biology have provided hope, for the first time, of addressing this underlying pathology.
Lovell, Matthew J, Lovell, Matthew J.
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1008 THEORETICAL AND BIOLOGICAL CONSIDERATIONS IN SUCCESSFUL MISMATCHED BONE MARROW TRANSPLANTATION [PDF]
, 1985 Robert C. Moen +6 more
openalex +1 more source
Advanced Science, EarlyView.This study reveals that Alzheimer's disease–linked APP expression in bone‐forming cells drives skull bone marrow remodeling and alters its vascular connections to the brain. These changes disrupt immune cell trafficking, cerebral blood flow, and cognition. Targeting bone marrow macrophages restores brain function, highlighting a previously unrecognized
Lei Xiong +6 more
wiley +1 more source
Bone marrow transplantation for thalassemia in Hong Kong: The early experience
, 1993 The first experience of bone marrow transplantation (BMT) for thalassemia in Hong Kong is reported. Of the three children transplanted using a matched allogeneic donor, two have been surviving disease free 291 and 256 days post-BMT respectively.
Chan, TK +6 more
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Advanced Science, EarlyView.This study identifies the mechanosensor PIEZO1 as a key factor in promoting acute myeloid leukemia progression and uncovers a ferroptosis defense system mediated by PIEZO1‐HIF1A‐SLC7A11 axis that is essential for leukemia stem cell maintenance. This ferroptotic defense system may represent a unique vulnerability for leukemia stem cells, providing a ...
Tiantian Zhang +10 more
wiley +1 more source
, 2008 Bone marrow transplantation (BMT) has been used for a wide variety of lysosomal storage diseases with encouraging results. We report a 3-year 5- month-old girl with Niemann- Pick type C disease (NPC) who received an allogeneic BMT, The patient presented ...
HSU, Y-S;HWU, WUH-LIANG;LU, MENG-YAO;CHEN, RONG-LONG;LIN, DONG-TSAMN;PENG, SHINN-FORNG;LIN, KAI-HSIN +1 more
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