Results 121 to 130 of about 366,647 (265)

Microtubule actin crosslinking factor 1 functions as a novel therapeutic target in lung metastasis of osteosarcoma

Genes and Diseases, 2023
Chaofei Yang, Ye Tian, Fan Zhao, Qian Huang, Zhiyong Liu, Chenyang He, Hui Li, Yu li, Zhiping Miao, Airong Qian   +9 more
doaj   +1 more source

Bone metabolism in primary hyperparathyroidism. [PDF]

Wien Klin Wochenschr
Kerschan-Schindl K, Gelles K, Butylina M, Crevenna R, Pietschmann P.   +4 more
europepmc   +1 more source

Adipocyte‐Derived Leptolin Enhances Energy Expenditure and Prevents Obesity

Advanced Science, EarlyView.
We identified a novel adipokine, which we named leptolin. In humans, leptolin levels in white adipose tissue were positively correlated with exercise and negatively associated with body mass index. We observed elevated leptolin in serum from athletes and lower leptolin in serum from obese individuals.
Jiarui Liu, Bingwei Wang, Zhijie Su, Xiaoxv Han, Miao He, Yun Zhao, Yujia Hou, Daotong Li, Weiguang Zhang, Lihua Qin, Ke Wang, Yanchun Li, Yi Yan, Siwang Yu, Xiaoshuai Huang, Tairan Yuwen, Jianyuan Luo, Ruimao Zheng   +17 more
wiley   +1 more source

Restoring cartilage-subchondral bone metabolism with biphasic magnesium microspheres ameliorate early osteoarthritis. [PDF]

Bioact Mater
Chen T, Zhi W, Wu G, He X, Wang H, Wang Z, Yang X, Qi X, Chen L, Rao S, Zheng L, Xu J, Zan G, Liu W, Liu Y, Wang J, Wang H, Zhang Y.   +17 more
europepmc   +1 more source

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

RNA Helicase DDX21 Controls CD4+ T Cell Proliferation and Promotes Inflammatory Bowel Disease via Translational Control

Advanced Science, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang, Chen Kan, Xinhui Yang, Yajuan Hao, Xuemin Cai, Mei Yang, Qianqian Zhang, Zhengting Wang, Ning Jiang, Lei Wang, Hua‐Bing Li, Jing Zhou   +11 more
wiley   +1 more source

The relationship between bone regulatory markers and bone turnover in renal osteodystrophy

Bone Reports, 2020
Syazrah Salam, Orla Gallagher, Fatma Gossiel, Arif Khwaja, Richard Eastell   +4 more
doaj   +1 more source

Bone metabolism and inflammation drive structural damage in rheumatoid arthritis: clustering and multivariable analysis. [PDF]

Ther Adv Musculoskelet Dis
Pollastri F, Viapiana O, Gatti D, Fassio A, Benini C, Dartizio C, Galvagni I, Messina V, Rossini M, Adami G.   +9 more
europepmc   +1 more source

Tropomyosin 1 Promotes Platelet Adhesion and Clot Contraction Separate from Its Roles in Developmental Hematopoiesis

Advanced Science, EarlyView.
ABSTRACT Genome‐wide association studies (GWAS) link the Tropomyosin 1 (Tpm1) locus to quantitative blood trait variation, but related mechanisms are unclear. Tpm1 encodes an actin‐binding protein that regulates actin filament diversity, cell adhesion, signaling, and actomyosin contractility.
Po‐Lun Kung, Victor Tsao, Alina D Peshkova, Oscar A. Marcos‐Contreras, Kim Ha, Brian M Dulmovits, Nkemdilim Okoli, Anvi Sinha, Gennadiy Fonar, Rong Qiu, Rolf D Bates, Janelle Yeboah, Carson Shalaby, Tyler Truex, Soomin Jeong, Edna C Hardeman, Peter W Gunning, Vladimir R Muzykantov, Jacob W Myerson, Christopher S Thom   +19 more
wiley   +1 more source

Advances in the regulation of bone metabolism by central nuclei: a new perspective on the brain-bone axis. [PDF]

Front Neurosci
Yang G, Huang X, Qiu D, Wang A, Liu D, Liu Z.   +5 more
europepmc   +1 more source