Results 1 to 10 of about 2,927,306 (408)

Pathogenesis of FGF23-Related Hypophosphatemic Diseases Including X-linked Hypophosphatemia

Endocrines, 2022
Since phosphate is indispensable for skeletal mineralization, chronic hypophosphatemia causes rickets and osteomalacia. Fibroblast growth factor 23 (FGF23), which is mainly produced by osteocytes in bone, functions as the central regulator of phosphate ...
Tatsuro Nakanishi, Toshimi Michigami
doaj   +1 more source

Rickets manifestations in a child with metaphyseal anadysplasia, report of a spontaneously resolving case

BMC Pediatrics, 2021
Introduction Rickets is not an unusual diagnosis for pediatricians even currently in developed countries. Children typically present with leg bowing, enlargement of wrists, rachitic rosary (swelling of costochondral junctions) and/or waddling gait.
Patricia Diaz Escagedo, Melissa Fiscaletti, Patricia Olivier, Chloé Hudon, Valancy Miranda, Marie-Claude Miron, Philippe M. Campeau, Nathalie Alos   +7 more
doaj   +1 more source

Mineral maturity and crystallinity index are distinct characteristics of bone mineral [PDF]

, 2010
The purpose of this study was to test the hypothesis that mineral maturity and crystallinity index are two different characteristics of bone mineral. To this end, Fourier transform infrared microspectroscopy (FTIRM) was used.
A Boskey, A Carden, A Carden, A Gee, A Shemesh, AB Barry, AC Ferrari, AL Boskey, AL Boskey, AL Boskey, AS Posner, B Giri, C Jager, C Rey, C Rey, C Rey, C Rey, CH Turner, CH Turner, CH Turner, Christian Rey, CP Tarnowski, D Chachra, D Faibish, Delphine Farlay, E Durchschlag, E Fitzer EG, E Pucéat, EP Paschalis, EP Paschalis, EP Paschalis, EP Paschalis, G Boivin, Georges Boivin, Gérard Panczer, J Green, JD Termine, JS Yerramshetty, JW Ager, KL Dziak, L Nasdala, LM Miller, LM Miller, LM Miller, MD Grynpas, MD Morris, MG Glimcher, N Pleshko, NP Camacho, O Akkus, O Akkus, P Fratzl, P Fratzl, PD Frazier, Pierre D. Delmas, RG Hanschin, RY Huang, RZ Legeros, S Bang, S Bohic, S Cazalbou, S Tadano, SJ Gadaleta, WJ Landis, Y Li   +64 more
core   +3 more sources

Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis.

New England Journal of Medicine, 2001
BACKGROUND Once-daily injections of parathyroid hormone or its amino-terminal fragments increase bone formation and bone mass without causing hypercalcemia, but their effects on fractures are unknown.
R. Neer, C. Arnaud, J. Zanchetta, R. Prince, G. Gaich, J. Reginster, A. Hodsman, E. Eriksen, S. Ish-shalom, H. Genant, O. Wang, B. Mitlak   +11 more
semanticscholar   +1 more source

Large parathyroid adenomas: Potential mechanisms to reconcile adenoma size and disease phenotype

Frontiers in Endocrinology, 2023
Parathyroid adenomas weighing more than 3.5 g are reported variously as “atypical”, “large” or “giant” parathyroid adenomas. All such adenomas are rare variants accounting for no more than 1.5% of all parathyroid adenomas.
Arti Bhan, Shobana Athimulam, Poonam Kumari, Rimesh Pal, Sanjay Kumar Bhadada, Bernard C. Cook, Shijing Qiu, Sudhaker D. Rao, Sudhaker D. Rao   +8 more
doaj   +1 more source

Bone mineral: new insights into its chemical composition

Scientific Reports, 2019
Some compositional and structural features of mature bone mineral particles remain unclear. They have been described as calcium-deficient and hydroxyl-deficient carbonated hydroxyapatite particles in which a fraction of the PO43− lattice sites are ...
S. Von Euw, Yan Wang, G. Laurent, C. Drouet, F. Babonneau, Nadine Nassif, T. Azaïs   +6 more
semanticscholar   +1 more source

Adjusting bone mass for differences in projected bone area and other confounding variables: an allometric perspective. [PDF]

, 2002
The traditional method of assessing bone mineral density (BMD; given by bone mineral content [BMC] divided by projected bone area [Ap], BMD = BMC/Ap) has come under strong criticism by various authors. Their criticism being that the projected bone "area"
Alan M. Nevill, Bonjour, Boot, Carter, Cheng, Cox, Durnin, Frost, Frost, Frost, Goldstein, Goldstein, Jack C. Y. Cheng, Joseph T. F. Lau, Katzman, Lehtonen-Veromaa, Lu, Morris, Nelson, Nevill, Nevill, Nevill, Nichols, Nicola Maffulli, Nordstrom, Robinson, Roger L. Holder, Schmidt-Nielsen, Slemenda, Sophie S. S. F. Leung, Stewart, Taaffe, Teegarden, Valimaki, Warren T. K. Lee, White   +35 more
core   +2 more sources

Lack of PTEN in osteocytes increases circulating phosphate concentrations by decreasing intact fibroblast growth factor 23 levels

Scientific Reports, 2020
Fibroblast growth factor 23 (FGF23) has been centric to the regulation of phosphate (Pi) metabolism; however, the regulatory network of FGF23 in osteocytes has not yet been defined in detail.
Masanobu Kawai, Saori Kinoshita, Keiichi Ozono, Toshimi Michigami   +3 more
doaj   +1 more source

Multitasking by the OC Lineage during Bone Infection: Bone Resorption, Immune Modulation, and Microbial Niche

Cells, 2020
Bone infections, also known as infectious osteomyelitis, are accompanied by significant inflammation, osteolysis, and necrosis. Osteoclasts (OCs) are the bone-resorbing cells that work in concert with osteoblasts and osteocytes to properly maintain ...
Philip M. Roper, Christine Shao, Deborah J. Veis   +2 more
doaj   +1 more source

Mathematical model for bone mineralization [PDF]

Frontiers in Cell and Developmental Biology, 2015
Defective bone mineralization has serious clinical manifestations, including deformities and fractures, but the regulation of this extracellular process is not fully understood. We have developed a mathematical model consisting of ordinary differential equations that describe collagen maturation, production and degradation of inhibitors, and mineral ...
Svetlana V Komarova, Svetlana V Komarova, Lee eSafranek, Jay eGopalakrishnan, Miao-jung Yvonne Ou, Marc D Mckee, Marc D Mckee, Monzur eMurshed, Monzur eMurshed, Frank eRauch, Erica eZuhr   +10 more
openaire   +5 more sources