Results 1 to 10 of about 259,849 (237)

Failure of Mineralized Collagen Microfibrils Using Finite Element Simulation Coupled to Mechanical Quasi-brittle Damage [PDF]

Procedia engineering 10 (2011) 3193-3198, 2011
Bone is a multiscale heterogeneous materiel of which principal function is to support the body structure and to resist mechanical loading and fractures. Bone strength does not depend only on the quantity and quality of bone which is characterized by the geometry and the shape of bones but also on the mechanical proprieties of its compounds, which have ...
Abdelwahed Barkaoui, Awad Bettamer, Baselt, Currey, Fratzl, Habelitz, Holmes, Hulmes, Jae-Young Rhao, Knott, Lemaitre, Markus, Markus, Matthew, Nagaraja, Raspanti, Ridha Hambli, Stephen, Thomas Siegmund, Vashishth, Viguet-Carrin, Viguet-Carrin, Wang, Wu   +23 more
arxiv   +4 more sources

Multiple verification in computational modeling of bone pathologies [PDF]

EPTCS 67, 2011, pp. 82-96, 2011
We introduce a model checking approach to diagnose the emerging of bone pathologies. The implementation of a new model of bone remodeling in PRISM has led to an interesting characterization of osteoporosis as a defective bone remodeling dynamics with respect to other bone pathologies.
A. Aziz, D.T. Gillespie, E. Bartocci, E. Bartocci, E. Bartocci, Emanuela Merelli, Erik de Vink, G. Karsenty, Ion Petre, L.J. Raggatt, M. Calder, M. Kwiatkowska, M. Kwiatkowska, N. Paoletti, Nicola Paoletti, P. Lió, Pietro Liò, R. Barbuti, R. Hanada, S. Jabbar, S.C. Manolagas, T.E. Pronk   +21 more
arxiv   +4 more sources

Bone Quality in CKD Patients: Current Concepts and Future Directions – Part I

Kidney Diseases, 2021
Background: There is ample evidence that patients with CKD have an increased risk of osteoporotic fractures. Bone fragility is not only influenced by low bone volume and mass but also by poor microarchitecture and tissue quality.
Kamyar Asadipooya, Mohamed Abdalbary, Yahya Ahmad, Elijah Kakani, Marie-Claude Monier-Faugere, Amr El-Husseini   +5 more
doaj   +1 more source

Bone Quality in Chronic Kidney Disease Patients: Current Concepts and Future Directions – Part II

Kidney Diseases, 2021
Background: Patients with chronic kidney disease (CKD) have an increased risk of osteoporotic fractures, which is due not only to low bone volume and mass but also poor microarchitecture and tissue quality.
Kamyar Asadipooya, Mohamed Abdalbary, Yahya Ahmad, Elijah Kakani, Marie-Claude Monier-Faugere, Amr El-Husseini   +5 more
doaj   +1 more source

Bone remodeling: an operational process ensuring survival and bone mechanical competence

Bone Research, 2022
Bone remodeling replaces old and damaged bone with new bone through a sequence of cellular events occurring on the same surface without any change in bone shape.
Simona Bolamperti, Isabella Villa, Alessandro Rubinacci   +2 more
doaj   +1 more source

Molecular origin of viscoelasticity in mineralized collagen fibrils [PDF]

Biomaterials Science, 9(9), 3390-3400 (2021), 2021
Bone is mineralized tissue constituting the skeletal system, supporting and protecting body organs and tissues. At the molecular level, mineralized collagen fibril is the basic building block of bone tissue, and hence, understanding bone properties down to fundamental tissue structures enables to better identify the mechanisms of structural failures ...
arxiv   +1 more source

A bone-specific adipogenesis pathway in fat-free mice defines key origins and adaptations of bone marrow adipocytes with age and disease

eLife, 2021
Bone marrow adipocytes accumulate with age and in diverse disease states. However, their origins and adaptations in these conditions remain unclear, impairing our understanding of their context-specific endocrine functions and relationship with ...
Xiao Zhang, Hero Robles, Kristann L Magee, Madelyn R Lorenz, Zhaohua Wang, Charles A Harris, Clarissa S Craft, Erica L Scheller   +7 more
doaj   +1 more source

Theoretical and experimental study of attenuation in cancellous bone [PDF]

Wenyi Xu, Weiya Xie, Dong Yu, Haohan Sun, Ying Gu, Xingliang Tao, Menglu Qian, Liming Cheng, Hao Wang, Qian Cheng, Theoretical and experimental study of attenuation in cancellous bone, J. Biomed. Opt. 29(S1), S11526 (2024), 2023
Photoacoustic (PA) technology can provide information on both the physical structure and chemical composition of bone, showing great potential in bone assessment. However, due to the complex composition and porous structure of cancellous bone, the PA signals generated and propagated in cancellous bone are complex and difficult to be directly used in ...
arxiv   +1 more source

Molecular Mechanisms of Parathyroid Disorders in Chronic Kidney Disease

Metabolites, 2022
Secondary hyperparathyroidism (SHP) is a common complication of chronic kidney disease (CKD) that induces morbidity and mortality in patients. How CKD stimulates the parathyroid to increase parathyroid hormone (PTH) secretion, gene expression and cell ...
Alia Hassan, Nareman Khalaily, Rachel Kilav-Levin, Morris Nechama, Oded Volovelsky, Justin Silver, Tally Naveh-Many   +6 more
doaj   +1 more source

Conditional loss of IKKα in Osterix + cells has no effect on bone but leads to age-related loss of peripheral fat

Scientific Reports, 2022
NF-κB has been reported to both promote and inhibit bone formation. To explore its role in osteolineage cells, we conditionally deleted IKKα, an upstream kinase required for non-canonical NF-κB activation, using Osterix (Osx)-Cre.
Jennifer L. Davis, Nitin Kumar Pokhrel, Linda Cox, Nidhi Rohatgi, Roberta Faccio, Deborah J. Veis   +5 more
doaj   +1 more source