Results 11 to 20 of about 2,979,968 (410)

Conditional loss of IKKα in Osterix + cells has no effect on bone but leads to age-related loss of peripheral fat

Scientific Reports, 2022
NF-κB has been reported to both promote and inhibit bone formation. To explore its role in osteolineage cells, we conditionally deleted IKKα, an upstream kinase required for non-canonical NF-κB activation, using Osterix (Osx)-Cre.
Jennifer L. Davis, Nitin Kumar Pokhrel, Linda Cox, Nidhi Rohatgi, Roberta Faccio, Deborah J. Veis   +5 more
doaj   +1 more source

Rickets manifestations in a child with metaphyseal anadysplasia, report of a spontaneously resolving case

BMC Pediatrics, 2021
Introduction Rickets is not an unusual diagnosis for pediatricians even currently in developed countries. Children typically present with leg bowing, enlargement of wrists, rachitic rosary (swelling of costochondral junctions) and/or waddling gait.
Patricia Diaz Escagedo, Melissa Fiscaletti, Patricia Olivier, Chloé Hudon, Valancy Miranda, Marie-Claude Miron, Philippe M. Campeau, Nathalie Alos   +7 more
doaj   +1 more source

Pathogenesis of FGF23-Related Hypophosphatemic Diseases Including X-linked Hypophosphatemia

Endocrines, 2022
Since phosphate is indispensable for skeletal mineralization, chronic hypophosphatemia causes rickets and osteomalacia. Fibroblast growth factor 23 (FGF23), which is mainly produced by osteocytes in bone, functions as the central regulator of phosphate ...
Tatsuro Nakanishi, Toshimi Michigami
doaj   +1 more source

Mineral maturity and crystallinity index are distinct characteristics of bone mineral [PDF]

, 2010
The purpose of this study was to test the hypothesis that mineral maturity and crystallinity index are two different characteristics of bone mineral. To this end, Fourier transform infrared microspectroscopy (FTIRM) was used.
A Boskey, A Carden, A Carden, A Gee, A Shemesh, AB Barry, AC Ferrari, AL Boskey, AL Boskey, AL Boskey, AS Posner, B Giri, C Jager, C Rey, C Rey, C Rey, C Rey, CH Turner, CH Turner, CH Turner, Christian Rey, CP Tarnowski, D Chachra, D Faibish, Delphine Farlay, E Durchschlag, E Fitzer EG, E Pucéat, EP Paschalis, EP Paschalis, EP Paschalis, EP Paschalis, G Boivin, Georges Boivin, Gérard Panczer, J Green, JD Termine, JS Yerramshetty, JW Ager, KL Dziak, L Nasdala, LM Miller, LM Miller, LM Miller, MD Grynpas, MD Morris, MG Glimcher, N Pleshko, NP Camacho, O Akkus, O Akkus, P Fratzl, P Fratzl, PD Frazier, Pierre D. Delmas, RG Hanschin, RY Huang, RZ Legeros, S Bang, S Bohic, S Cazalbou, S Tadano, SJ Gadaleta, WJ Landis, Y Li   +64 more
core   +3 more sources

Large parathyroid adenomas: Potential mechanisms to reconcile adenoma size and disease phenotype

Frontiers in Endocrinology, 2023
Parathyroid adenomas weighing more than 3.5 g are reported variously as “atypical”, “large” or “giant” parathyroid adenomas. All such adenomas are rare variants accounting for no more than 1.5% of all parathyroid adenomas.
Arti Bhan, Shobana Athimulam, Poonam Kumari, Rimesh Pal, Sanjay Kumar Bhadada, Bernard C. Cook, Shijing Qiu, Sudhaker D. Rao, Sudhaker D. Rao   +8 more
doaj   +1 more source

High‐Intensity Resistance and Impact Training Improves Bone Mineral Density and Physical Function in Postmenopausal Women With Osteopenia and Osteoporosis: The LIFTMOR Randomized Controlled Trial

Journal of Bone and Mineral Research, 2019
Optimal osteogenic mechanical loading requires the application of high-magnitude strains at high rates. High-intensity resistance and impact training (HiRIT) applies such loads but is not traditionally recommended for individuals with osteoporosis ...
S. Watson, B. Weeks, L. Weis, A. Harding, Sean A. Horan, Belinda R. Beck   +5 more
semanticscholar   +1 more source

Bone mineral density and fracture risk with long-term use of inhaled corticosteroids in patients with asthma: systematic review and meta-analysis [PDF]

, 2015
Objectives: We aimed to assess the association between long-term use of inhaled corticosteroids (ICS) and bone adverse effects in patients with asthma. Design: Systematic review and meta-analysis of fracture risk and changes in bone mineral density with ...
Agertoft, Allen, Bahceciler, British-Thoracic-Society/Scottish-Intercollegiate-Guidelines-Network, El, Ferguson, Harris, Higgins, Higgins, Ioannidis, Johannes, Jones, Kelly, Kemp, Law, Li, Loke, Loke, Maspero, National-Asthma-Education-and-Prevention-Program, Ricciardolo, Richy, Rossi, Roux, Schlienger, Sosa, The Childhood Asthma Management Program Research Group, Turpeinen, Van Staa, Vanfleteren, Weatherall, Wisniewski, Yanik   +32 more
core   +1 more source

N-cadherin in osteolineage cells modulates stromal support of tumor growth

Journal of Bone Oncology, 2021
Tumor growth and metastases are dependent on interactions between cancer cells and the local environment. Expression of the cell–cell adhesion molecule N-cadherin (Ncad) is associated with highly aggressive cancers, and its expression by osteogenic cells
Francesca Fontana, Jingyu Xiang, Xinming Su, Eric Tycksen, Rachel Nassau, Gregory Fox, Giulia Leanza, Katherine Weilbaecher, Roberto Civitelli   +8 more
doaj   +1 more source

Bone mineral: new insights into its chemical composition

Scientific Reports, 2019
Some compositional and structural features of mature bone mineral particles remain unclear. They have been described as calcium-deficient and hydroxyl-deficient carbonated hydroxyapatite particles in which a fraction of the PO43− lattice sites are ...
S. Von Euw, Yan Wang, G. Laurent, C. Drouet, F. Babonneau, Nadine Nassif, T. Azaïs   +6 more
semanticscholar   +1 more source

A retrospective analysis of longitudinal changes in bone mineral content in cystic fibrosis [PDF]

, 2017
Background: We aimed to describe the longitudinal changes in bone mineral content and influencing factors, in children with cystic fibrosis (CF). Methods: One hundred children (50 females) had dual X-ray absorptiometry (DXA) performed.
Ahmed, Syed Faisal, Chirita-Emandi, Adela, Corrigan, Donna, Devenny, Anne, Dryden, Carol, Kyriakou, Andreas, McNeilly, Jane D., Shepherd, Sheila   +7 more
core   +1 more source