Results 11 to 20 of about 226,513 (310)

Bone Quality in CKD Patients: Current Concepts and Future Directions – Part I

Kidney Diseases, 2021
Background: There is ample evidence that patients with CKD have an increased risk of osteoporotic fractures. Bone fragility is not only influenced by low bone volume and mass but also by poor microarchitecture and tissue quality.
Kamyar Asadipooya, Mohamed Abdalbary, Yahya Ahmad, Elijah Kakani, Marie-Claude Monier-Faugere, Amr El-Husseini   +5 more
doaj   +1 more source

Bone Quality in Chronic Kidney Disease Patients: Current Concepts and Future Directions – Part II

Kidney Diseases, 2021
Background: Patients with chronic kidney disease (CKD) have an increased risk of osteoporotic fractures, which is due not only to low bone volume and mass but also poor microarchitecture and tissue quality.
Kamyar Asadipooya, Mohamed Abdalbary, Yahya Ahmad, Elijah Kakani, Marie-Claude Monier-Faugere, Amr El-Husseini   +5 more
doaj   +1 more source

Bone remodeling: an operational process ensuring survival and bone mechanical competence

Bone Research, 2022
Bone remodeling replaces old and damaged bone with new bone through a sequence of cellular events occurring on the same surface without any change in bone shape.
Simona Bolamperti, Isabella Villa, Alessandro Rubinacci   +2 more
doaj   +1 more source

Effect of vitamin D metabolites on bone histomorphometry in healthy black and white women: An attempt to unravel the so-called vitamin D paradox in blacks

Bone Reports, 2023
An apparent vitamin D paradox, characterized by lower serum 25-hydroxyvitamin D (25(OH)D) levels and higher bone mineral density, is present in black population. In contrast, blacks have higher serum 1,25-dihydroxyvitamin D (1,25(OH)2D) levels.
Shijing Qiu, George Divine, Sudhaker D. Rao   +2 more
doaj   +1 more source

Kidney Recovery in Patients With Acute Kidney Injury Treated in Outpatient Hemodialysis or Rehabilitation FacilitiesPlain-Language Summary

Kidney Medicine, 2021
Rationale & Objective: Since January 2017, patients with acute kidney injury requiring dialysis (AKI-D) can be discharged to outpatient dialysis centers for continued hemodialysis (HD) support. We aimed to examine the rate of kidney recovery, time to
Melissa Jordan, Victor Ortiz-Soriano, Aaron Pruitt, Lauren Chism, Lucas J. Liu, Nourhan Chaaban, Madona Elias, B. Peter Sawaya, Jin Chen, Javier A. Neyra   +9 more
doaj   +1 more source

A bone-specific adipogenesis pathway in fat-free mice defines key origins and adaptations of bone marrow adipocytes with age and disease

eLife, 2021
Bone marrow adipocytes accumulate with age and in diverse disease states. However, their origins and adaptations in these conditions remain unclear, impairing our understanding of their context-specific endocrine functions and relationship with ...
Xiao Zhang, Hero Robles, Kristann L Magee, Madelyn R Lorenz, Zhaohua Wang, Charles A Harris, Clarissa S Craft, Erica L Scheller   +7 more
doaj   +1 more source

Compound loss of GSDMD and GSDME function is necessary to achieve maximal therapeutic effect in colitis

Journal of Translational Autoimmunity, 2022
Gasdermin D (GSDMD) and gasdermin E (GSDME) perpetuate inflammation by mediating the release of cytokines such as interleukin-1β (IL-1β) and IL-18. However, not only are the actions of GSDMD in colitis still controversial, but its interplay with GSDME in
Jianqiu Xiao, Kai Sun, Chun Wang, Yousef Abu-Amer, Gabriel Mbalaviele   +4 more
doaj   +1 more source

Molecular Mechanisms of Parathyroid Disorders in Chronic Kidney Disease

Metabolites, 2022
Secondary hyperparathyroidism (SHP) is a common complication of chronic kidney disease (CKD) that induces morbidity and mortality in patients. How CKD stimulates the parathyroid to increase parathyroid hormone (PTH) secretion, gene expression and cell ...
Alia Hassan, Nareman Khalaily, Rachel Kilav-Levin, Morris Nechama, Oded Volovelsky, Justin Silver, Tally Naveh-Many   +6 more
doaj   +1 more source

Conditional loss of IKKα in Osterix + cells has no effect on bone but leads to age-related loss of peripheral fat

Scientific Reports, 2022
NF-κB has been reported to both promote and inhibit bone formation. To explore its role in osteolineage cells, we conditionally deleted IKKα, an upstream kinase required for non-canonical NF-κB activation, using Osterix (Osx)-Cre.
Jennifer L. Davis, Nitin Kumar Pokhrel, Linda Cox, Nidhi Rohatgi, Roberta Faccio, Deborah J. Veis   +5 more
doaj   +1 more source

Pathogenesis of FGF23-Related Hypophosphatemic Diseases Including X-linked Hypophosphatemia

Endocrines, 2022
Since phosphate is indispensable for skeletal mineralization, chronic hypophosphatemia causes rickets and osteomalacia. Fibroblast growth factor 23 (FGF23), which is mainly produced by osteocytes in bone, functions as the central regulator of phosphate ...
Tatsuro Nakanishi, Toshimi Michigami
doaj   +1 more source