Results 21 to 30 of about 2,927,306 (408)

Bone mineral organization at the mesoscale: A review of mineral ellipsoids in bone and at bone interfaces

Acta Biomaterialia, 2022
Much debate still revolves around bone architecture, especially at the nano- and microscale. Bone is a remarkable material where high strength and toughness coexist thanks to an optimized composition of mineral and protein and their hierarchical organization across several distinct length scales.
Chiara Micheletti, Ariana Hurley, Aurélien Gourrier, Anders Palmquist, Tengteng Tang, Furqan A. Shah, Kathryn Grandfield   +6 more
openaire   +3 more sources

Bone Nanomechanical Properties and Relationship to Bone Turnover and Architecture in Patients With Atypical Femur Fractures: A Prospective Nested Case‐Control Study

JBMR Plus, 2021
Atypical femur fractures (AFFs) are well‐established serious complication of long‐term bisphosphonate and denosumab therapy in patients with osteopenia or osteoporosis.
Lanny V. Griffin, Elizabeth Warner, Saroj Palnitkar, Shijing Qiu, Mahalakshmi Honasoge, Shawna G. Griffin, George Divine, Sudhaker D. Rao   +7 more
doaj   +1 more source

Bone mineral density and fracture risk with long-term use of inhaled corticosteroids in patients with asthma: systematic review and meta-analysis [PDF]

, 2015
Objectives: We aimed to assess the association between long-term use of inhaled corticosteroids (ICS) and bone adverse effects in patients with asthma. Design: Systematic review and meta-analysis of fracture risk and changes in bone mineral density with ...
Agertoft, Allen, Bahceciler, British-Thoracic-Society/Scottish-Intercollegiate-Guidelines-Network, El, Ferguson, Harris, Higgins, Higgins, Ioannidis, Johannes, Jones, Kelly, Kemp, Law, Li, Loke, Loke, Maspero, National-Asthma-Education-and-Prevention-Program, Ricciardolo, Richy, Rossi, Roux, Schlienger, Sosa, The Childhood Asthma Management Program Research Group, Turpeinen, Van Staa, Vanfleteren, Weatherall, Wisniewski, Yanik   +32 more
core   +1 more source

Identification of 613 new loci associated with heel bone mineral density and a polygenic risk score for bone mineral density, osteoporosis and fracture

PLoS ONE, 2018
Low bone mineral density (BMD) leads to osteoporosis, and is a risk factor for bone fractures, including stress fractures. Using data from UK Biobank, a genome-wide association study identified 1,362 independent SNPs that clustered into 899 loci of which
Stuart K. Kim
semanticscholar   +1 more source

Bone matrix components activate the NLRP3 inflammasome and promote osteoclast differentiation

Scientific Reports, 2017
The NLRP3 inflammasome senses a variety of signals referred to as danger associated molecular patterns (DAMPs), including those triggered by crystalline particulates or degradation products of extracellular matrix. Since some DAMPs confer tissue-specific
Yael Alippe, Chun Wang, Biancamaria Ricci, Jianqiu Xiao, Chao Qu, Wei Zou, Deborah V. Novack, Yousef Abu-Amer, Roberto Civitelli, Gabriel Mbalaviele   +9 more
doaj   +1 more source

A Novel Osseous Densification Approach in Implant Osteotomy Preparation to Increase Biomechanical Primary Stability, Bone Mineral Density, and Bone-to-Implant Contact.

The International Journal of Oral and Maxillofacial Implants, 2017
PURPOSE It is essential to have sufficient bone bulk and density at the implant site in order to achieve good bone-to-implant contact and primary stability, which are crucial for osseointegration.
Salah Huwais, E. Meyer
semanticscholar   +1 more source

Chronic inflammation triggered by the NLRP3 inflammasome in myeloid cells promotes growth plate dysplasia by mesenchymal cells

Scientific Reports, 2017
Skeletal complications are common features of neonatal-onset multisystem inflammatory disease (NOMID), a disorder caused by NLRP3-activating mutations. NOMID mice in which NLRP3 is activated globally exhibit several characteristics of the human disease ...
Chun Wang, Can-Xin Xu, Yael Alippe, Chao Qu, Jianqiu Xiao, Ernestina Schipani, Roberto Civitelli, Yousef Abu-Amer, Gabriel Mbalaviele   +8 more
doaj   +1 more source

A retrospective analysis of longitudinal changes in bone mineral content in cystic fibrosis [PDF]

, 2017
Background: We aimed to describe the longitudinal changes in bone mineral content and influencing factors, in children with cystic fibrosis (CF). Methods: One hundred children (50 females) had dual X-ray absorptiometry (DXA) performed.
Ahmed, Syed Faisal, Chirita-Emandi, Adela, Corrigan, Donna, Devenny, Anne, Dryden, Carol, Kyriakou, Andreas, McNeilly, Jane D., Shepherd, Sheila   +7 more
core   +1 more source

Romosozumab in postmenopausal women with low bone mineral density

New England Journal of Medicine, 2014
BACKGROUND Sclerostin is an osteocyte-derived inhibitor of osteoblast activity. The monoclonal antibody romosozumab binds to sclerostin and increases bone formation.
Sara L White
semanticscholar   +1 more source

Mechanism of Bone Mineralization [PDF]

Cold Spring Harbor Perspectives in Medicine, 2018
Mineralized "hard" tissues of the skeleton possess unique biomechanical properties to support the body weight and movement and act as a source of essential minerals required for critical body functions. For a long time, extracellular matrix (ECM) mineralization in the vertebrate skeleton was considered as a passive process.
openaire   +3 more sources