Results 21 to 30 of about 3,036,943 (405)

N-cadherin in osteolineage cells modulates stromal support of tumor growth

Journal of Bone Oncology, 2021
Tumor growth and metastases are dependent on interactions between cancer cells and the local environment. Expression of the cell–cell adhesion molecule N-cadherin (Ncad) is associated with highly aggressive cancers, and its expression by osteogenic cells
Francesca Fontana, Jingyu Xiang, Xinming Su, Eric Tycksen, Rachel Nassau, Gregory Fox, Giulia Leanza, Katherine Weilbaecher, Roberto Civitelli   +8 more
doaj   +1 more source

Thyroid hormone status within the physiological range affects bone mass and density in healthy men at the age of peak bone mass [PDF]

, 2011
Context: The hormonal factors involved in the regulation of peak bone mass (PBM) in men have not been fully investigated. Apart from gonadal steroids and somatotropic hormones, thyroid hormones are known to affect bone maturation and homeostasis and are ...
Fiers, Tom, Goemaere, Stefan, Kaufman, Jean, Lapauw, Bruno, ROEF, GREET, Taes, Youri, Zmierczak, Hans-Georg   +6 more
core   +2 more sources

Lack of PTEN in osteocytes increases circulating phosphate concentrations by decreasing intact fibroblast growth factor 23 levels

Scientific Reports, 2020
Fibroblast growth factor 23 (FGF23) has been centric to the regulation of phosphate (Pi) metabolism; however, the regulatory network of FGF23 in osteocytes has not yet been defined in detail.
Masanobu Kawai, Saori Kinoshita, Keiichi Ozono, Toshimi Michigami   +3 more
doaj   +1 more source

Multitasking by the OC Lineage during Bone Infection: Bone Resorption, Immune Modulation, and Microbial Niche

Cells, 2020
Bone infections, also known as infectious osteomyelitis, are accompanied by significant inflammation, osteolysis, and necrosis. Osteoclasts (OCs) are the bone-resorbing cells that work in concert with osteoblasts and osteocytes to properly maintain ...
Philip M. Roper, Christine Shao, Deborah J. Veis   +2 more
doaj   +1 more source

Bone mineral: update on chemical composition and structure [PDF]

, 2009
Bone mineral: update on chemical composition and ...
Combes, Christèle, Drouet, Christophe, Glimcher, Melvin J., Rey, Christian   +3 more
core   +2 more sources

Lactobacillus reuteri reduces bone loss in older women with low bone mineral density: a randomized, placebo‐controlled, double‐blind, clinical trial

Journal of Internal Medicine, 2018
The importance of the gut microbiome for bone metabolism in mice has recently been demonstrated, but no studies are available in humans. Lactobacillus reuteri ATCCPTA 6475 (L. reuteri 6475) has been reported to increase bone mineral density (BMD) in mice
Anna G. Nilsson, Anna G. Nilsson, D. Sundh, Fredrik Bäckhed, Fredrik Bäckhed, M. Lorentzon, M. Lorentzon   +6 more
semanticscholar   +1 more source

Bone Nanomechanical Properties and Relationship to Bone Turnover and Architecture in Patients With Atypical Femur Fractures: A Prospective Nested Case‐Control Study

JBMR Plus, 2021
Atypical femur fractures (AFFs) are well‐established serious complication of long‐term bisphosphonate and denosumab therapy in patients with osteopenia or osteoporosis.
Lanny V. Griffin, Elizabeth Warner, Saroj Palnitkar, Shijing Qiu, Mahalakshmi Honasoge, Shawna G. Griffin, George Divine, Sudhaker D. Rao   +7 more
doaj   +1 more source

Micro-CT Characterization of Human Trabecular Bone in Osteogenesis Imperfecta [PDF]

, 2011
Osteogenesis imperfecta (OI) is a genetic syndrome affecting collagen synthesis and assembly. Its symptoms vary widely but commonly include bone fragility, reduced stature, and bone deformity.
Albert, Carolyne, Harris, Gerald F, Jameson, John, Molthen, Robert C., Smith, Peter   +4 more
core   +2 more sources

Identification of 613 new loci associated with heel bone mineral density and a polygenic risk score for bone mineral density, osteoporosis and fracture

PLoS ONE, 2018
Low bone mineral density (BMD) leads to osteoporosis, and is a risk factor for bone fractures, including stress fractures. Using data from UK Biobank, a genome-wide association study identified 1,362 independent SNPs that clustered into 899 loci of which
Stuart K. Kim
semanticscholar   +1 more source

Bone matrix components activate the NLRP3 inflammasome and promote osteoclast differentiation

Scientific Reports, 2017
The NLRP3 inflammasome senses a variety of signals referred to as danger associated molecular patterns (DAMPs), including those triggered by crystalline particulates or degradation products of extracellular matrix. Since some DAMPs confer tissue-specific
Yael Alippe, Chun Wang, Biancamaria Ricci, Jianqiu Xiao, Chao Qu, Wei Zou, Deborah V. Novack, Yousef Abu-Amer, Roberto Civitelli, Gabriel Mbalaviele   +9 more
doaj   +1 more source