Results 31 to 40 of about 226,513 (310)
Knockout of TSC2 in Nav1.8+ neurons predisposes to the onset of normal weight obesity
Molecular Metabolism, 2023 Objective: Obesity and nutrient oversupply increase mammalian target of rapamycin (mTOR) signaling in multiple cell types and organs, contributing to the onset of insulin resistance and complications of metabolic disease. However, it remains unclear when
Jennifer M. Brazill +6 more
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Arthritis Research & Therapy, 2021 Background Gasdermin D (GSDMD) is cleaved by several proteases including by caspase-1, a component of intracellular protein complexes called inflammasomes.
Tong Yang +14 more
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Immunoporosis: Role of immune system in the pathophysiology of different types of osteoporosis
Frontiers in Endocrinology, 2022 Osteoporosis is a skeletal system disease characterized by low bone mass and altered bone microarchitecture, with an increased risk of fractures. Classical theories hold that osteoporosis is essentially a bone remodeling disorder caused by estrogen ...
Weidong Zhang +13 more
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Vitamin D and Serum Cytokines in a Randomized Clinical Trial
International Journal of Endocrinology, 2010 Background. The role of vitamin D in the body's ability to fight influenza and URI's may be dependent on regulation of specific cytokines that participate in the host inflammatory response.
Eleanor Yusupov +5 more
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Redox Metabolism and Vascular Calcification in Chronic Kidney Disease
Biomolecules, 2023 Vascular calcification (VC) is a common complication in patients with chronic kidney disease which increases their mortality. Although oxidative stress is involved in the onset and progression of this disorder, the specific role of some of the main redox
Natalia Carrillo-López +17 more
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Guidelines for the Diagnosis and Treatment of Primary Osteoporosis (2022) [PDF]
Zhongguo quanke yixue, 2023 Chinese Society of Osteoporosis and Bone Mineral Research
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Frontiers in Bioscience, 2012 This review attempts to summarize the findings made available by the literature on the mineralization of bone. The types of bone, their structures and compositions, the nature and organization of organic and inorganic matter, the organic-inorganic relationships, and the mineralization mechanism itself, are the main topics of the present review.
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Mechanism of Bone Mineralization [PDF]
Cold Spring Harbor Perspectives in Medicine, 2018 Mineralized "hard" tissues of the skeleton possess unique biomechanical properties to support the body weight and movement and act as a source of essential minerals required for critical body functions. For a long time, extracellular matrix (ECM) mineralization in the vertebrate skeleton was considered as a passive process.
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Frontiers in EndocrinologyBackgroundPrimary hyperparathyroidism (PHPT) is associated with an increased risk of kidney stones. However, the clinical utility of 24-hour urinary calcium (24h-UCa) as a predictor of nephrolithiasis, and its role in surgical decision-making, remains ...
Arti Bhan +9 more
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Bone Structure and Turnover in Postmenopausal Women With Long‐Standing Type 1 Diabetes
JBMR Plus, 2023 Compromised bone structural and mechanical properties are implicated in the increased fracture risk in type 1 diabetes (T1D). We investigated bone structure and turnover by histomorphometry in postmenopausal women with T1D and controls without diabetes ...
Viral N Shah +7 more
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