Results 1 to 10 of about 114,625 (144)

Bone morphogenetic protein 7 promotes resistance to immunotherapy. [PDF]

Nat Commun, 2020
AbstractImmunotherapies revolutionized cancer treatment by harnessing the immune system to target cancer cells. However, most patients are resistant to immunotherapies and the mechanisms underlying this resistant is still poorly understood. Here, we report that overexpression of BMP7, a member of the TGFB superfamily, represents a mechanism for ...
Cortez MA, Masrorpour F, Ivan C, Zhang J, Younes AI, Lu Y, Estecio MR, Barsoumian HB, Menon H, Caetano MDS, Ramapriyan R, Schoenhals JE, Wang X, Skoulidis F, Wasley MD, Calin G, Hwu P, Welsh JW.   +17 more
europepmc   +5 more sources

Role of bone morphogenetic protein-7 in renal fibrosis [PDF]

Frontiers in Physiology, 2015
published_or_final_versio
LI, R, Tang, SCW, Yiu, WH
core   +7 more sources

miR-4739 mediates pleural fibrosis by targeting bone morphogenetic protein 7. [PDF]

EBioMedicine, 2019
Pleural fibrosis is defined as excessive depositions of matrix components that result in pleural tissue architecture destruction and dysfunction. In severe cases, the progression of pleural fibrosis leads to lung entrapment, resulting in dyspnea and respiratory failure.
Wang M, Xiong L, Jiang LJ, Lu YZ, Liu F, Song LJ, Xiang F, He XL, Yu F, Shuai SY, Ma WL, Ye H.   +11 more
europepmc   +4 more sources

Guiding synovial inflammation by macrophage phenotype modulation: An in vitro study towards a therapy for osteoarthritis [PDF]

, 2016
Objective: The aims of this study were to modulate inflammation in synovial explants with the compounds: dexamethasone, rapamycin, bone morphogenetic protein 7 (BMP-7) and pravastatin, and to investigate the ...
Bastiaansen-Jenniskens, Y.M. (Yvonne), Bayon, Y. (Yves), Osch, G.J.V.M. (Gerjo) van, Utomo, L. (Lizette), Verhaar, J.A.N. (Jan)   +4 more
core   +4 more sources

Renal Bone Morphogenetic Protein-7 Protects against Diabetic Nephropathy [PDF]

Journal of the American Society of Nephrology, 2006
Longstanding diabetes causes renal injury with early dropout of podocytes, albuminuria, glomerular and tubulointerstitial fibrosis, and progressive renal failure. The renal pathology seems to be driven, in part, by TGF-beta and is associated with a loss of renal bone morphogenic protein-7 (BMP-7) expression.
Shinong, Wang, Mark, de Caestecker, Jeffrey, Kopp, Grace, Mitu, Janine, Lapage, Raimund, Hirschberg   +5 more
openaire   +2 more sources

Is NO the Answer? The Nitric Oxide Pathway Can Support Bone Morphogenetic Protein 2 Mediated Signaling [PDF]

, 2019
The growth factor bone morphogenetic protein 2 (BMP2) plays an important role in bone development and repair. Despite the positive effects of BMP2 in fracture healing, its use is associated with negative side effects and poor cost effectiveness, partly ...
Bormann, Nicole, Differ, Christopher, Klatte-Schulz, Franka, Knaus, Petra, Minkwitz, Susann, Wildemann, Britt   +5 more
core   +1 more source

Protein associated with SMAD1 (PAWS1/FAM83G) is a substrate for type I bone morphogenetic protein receptors and modulates bone morphogenetic protein signalling [PDF]

, 2014
Bone morphogenetic proteins (BMPs) control multiple cellular processes in embryos and adult tissues. BMPs signal through the activation of type I BMP receptor kinases, which then phosphorylate SMADs 1/5/8.
Campbell, David, Dingwell, Kevin S., Gourlay, Robert, Herhaus, Lina, Macartney, Thomas, Sapkota, Gopal P., Smith, James C., Vogt, Janis   +7 more
core   +3 more sources

Adsorption and release of BMP-2 on nanocrystalline apatite-coated and uncoated hydroxyapatite/b-tricalcium phosphate porous ceramics [PDF]

, 2009
The association of bone morphogenetic proteins (BMPs) with calcium phosphate bioceramics is known to confer them osteoinductive properties. The aim of this study was to evaluate the surface properties, especially regarding recombinant human BMP-2 (rhBMP-
Alam, Baig, Barroug, Barroug, Benaziz, Bohic, Boix, Charlot, Coradin, Daculsi, Dong, Frolik, Habibovic, Habibovic, Hayakawa, Hughes Wassell, Klenke, Le Nihouannen, Liu, Liu, Matsumoto, Midy, Midy, Murata, Ouizat, Rey, Rey, Rey, Rouahi, Ruppert, Scheufler, Schmoekel, Seeherman, Sumner, Tsujigiwa, Uludag, Vehof, Yuan, Zisch   +38 more
core   +3 more sources

Effect of sonic hedgehog/β-TCP composites on bone healing within the critical-sized rat femoral defect [PDF]

, 2013
The creation of entirely synthetically derived bone substitute materials which are as effective as autologous bone grafts is desirable. Osteogenesis involves the concerted action of several proteins within a signaling cascade.
Flinspach, Armin Niklas, Henrich, Dirk, Marzi, Ingo, Seebach, Caroline, Warzecha, Jörg, Wenger, Florian   +5 more
core   +1 more source

Bone Morphogenetic Protein 7 (BMP-7) Influences Tendon-Bone Integration In Vitro

PLOS ONE, 2015
Successful graft ingrowth following reconstruction of the anterior cruciate ligament is governed by complex biological processes at the tendon-bone interface. The aim of this study was to investigate in an in vitro study the effects of bone morphogenetic protein 7 (BMP-7) on tendon-bone integration.To study the biological effects of BMP-7 on the ...
Tim Schwarting, Philipp Lechler, Johannes Struewer, Marius Ambrock, Thomas Manfred Frangen, Steffen Ruchholtz, Ewgeni Ziring, Michael Frink   +7 more
openaire   +4 more sources