Results 211 to 220 of about 114,744 (263)

Unraveling Chronic Pain: From Mechanisms and Risks to Diagnosis and Treatment

MedComm, Volume 7, Issue 4, April 2026.
Chronic pain arises through distinct molecular pathways categorized into nociceptive, neuropathic, and nociplastic types. Nociceptive pain begins with TRP channel activation in peripheral nociceptors, signaling via Aδ‐ and C‐fibers through the spinal dorsal horn and spinothalamic tracts to the brain, regulated by descending inhibition and involving ...
Xiaofeng Dai, Chongxiang Wang, Ping Jiang, Xiaopeng Mei   +3 more
wiley   +1 more source

Magnesium and Strontium‐Doped Bioglass Nanoparticles as a Novel Formulation: Advancing Osteoconductivity and Enhancing Bone Healing Potential

Small Science, Volume 6, Issue 4, April 2026.
Bioactive glass nanoparticles were synthesized via the sol–gel method, incorporating osteoconductive strontium (Sr) and magnesium (Mg) ions at a novel compositional ratio to obtain a new multifunctional nanoparticle system. Comprehensive structural and morphological characterizations confirmed the successful incorporation of ions, the amorphous nature,
Mehraneh Movahedi Aliabadi, Afsaneh Jahani, Ali Moradi, Nafiseh Jirofti   +3 more
wiley   +1 more source

Bone morphogenetic protein-7 retards cell subculture-induced senescence of human nucleus pulposus cells through activating the PI3K/Akt pathway.

Biosci Rep, 2019
Gong C, Pan W, Hu W, Chen L, Chen L.
europepmc   +1 more source

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Meniscal repair possibilities using bone morphogenetic protein-7

Injury, 2014
This study analysed the influence of bone morphogenetic protein-7 (BMP-7) on cells and meniscal structure. The effect of treatment with BMP-7 was assessed in vitro and in vivo in lesions in the avascular area of the meniscus. Cells were extracted from the outer and inner part of eight menisci of four 2-year-old merino sheep.
Francisco, Forriol, Purificación, Ripalda, Julio, Duart, Raul, Esparza, Arancha R, Gortazar   +4 more
openaire   +2 more sources

Bone morphogenetic protein 7 ex vivo gene therapy

Drug News & Perspectives, 2003
Acquired and congenital skeletal defects arise from trauma and developmental abnormalities as well as ablative cancer surgery. Reconstructive surgery to repair the functional limitations and aesthetic concerns caused by these defects can be complex and extensive, and therapeutic restoration of structure and function is often difficult.
R Bruce, Rutherford, Brian, Nussenbaum, Paul H, Krebsbach   +2 more
openaire   +2 more sources

Bone morphogenetic protein-7 selectively enhances mechanically induced bone formation

Bone, 2002
The responses of bone cells to skeletal loading are clearly an important factor in bone biology, but much remains to be learned about the role of these responses in skeletal development, maintenance, and tissue repair. Bone morphogenetic proteins (BMPs) are key regulators of bone formation.
A J, Cheline, A H, Reddi, R B, Martin
openaire   +2 more sources

Cerebrospinal Fluid Contains Biologically Active Bone Morphogenetic Protein-7

Experimental Neurology, 2001
Bone morphogenetic proteins (BMPs) regulate the development and function of many types of neurons. However, little is known of the actual concentrations of BMPs in the various parts of the brain. In this study, we considered the possibility that BMPs might be present in cerebrospinal fluid (CSF).
B, Dattatreyamurty, E, Roux, C, Horbinski, P L, Kaplan, L A, Robak, H N, Beck, P, Lein, D, Higgins, V, Chandrasekaran   +8 more
openaire   +2 more sources

Bone morphogenetic protein-7 (BMP7) in chronic kidney disease

Frontiers in Bioscience, 2008
Bone morphogenetic protein-7 (BMP7) is a member of the BMP-subfamily of perhaps a dozen proteins within the TGFbeta-superfamily of cysteine-knot fold cytokine-growth factors. BMP7 has pivotal functions during renal and eye development. In adult organisms, BMP7 is heavily expressed in kidney, specifically in podocytes, distal tubules and collecting ...
Grace, Mitu, Raimund, Hirschberg
openaire   +2 more sources

Expression of bone morphogenetic protein‐7 (BMP‐7) in human prostate

The Prostate, 2004
AbstractBACKGROUNDIt is known that BMP is a factor that strongly induces bone formation in muscle tissue. However, the expression of BMP‐7 is not detected in normal bone tissues. Recently, we reported that the level of BMP‐7 expression was significantly higher in metastatic bone lesions than in normal bone and that the high expression of BMP‐7 in ...
Hiroshi, Masuda, Yoshitatsu, Fukabori, Katsuya, Nakano, Nobuaki, Shimizu, Hidetoshi, Yamanaka   +4 more
openaire   +2 more sources