Results 171 to 180 of about 69,320 (294)

Jervell and Lange‐Nielsen Syndrome Related Clinical Genetics and Experimental Models

open access: yesPediatric Discovery, EarlyView.
ABSTRACT Jervell and Lange‐Nielsen syndrome (JLNS) is defined by electrocardiographic QT prolongation and sensorineural hearing loss, caused by homozygous or compound heterozygous variants in KCNQ1 and/or KCNE1. KCNQ1 encodes the alpha subunit Kv7.1 of the ion channels accountable for slow delayed rectifier potassium currents (IKs), whereas KCNE1 ...
Yafei Zhou   +3 more
wiley   +1 more source

The role of bone morphogenetic proteins in myeloma cell survival

open access: yes, 2014
Multiple myeloma is characterized by slowly growing clones of malignant plasma cells in the bone marrow. The malignant state is frequently accompanied by osteolytic bone disease due to a disturbed balance between osteoblasts and osteoclasts.
Holien, Toril, Sundan, Anders
core  

Current Cell/Organoid and Animal Models for Primary Sclerosing Cholangitis

open access: yesPortal Hypertension &Cirrhosis, EarlyView.
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease with limited therapeutic options and a marked risk of progression to biliary fibrosis, cirrhosis, and malignancy. Progress in PSC research has been hindered by the lack of models that faithfully recapitulate the complex biliary microenvironment and disease heterogeneity ...
Qigu Yao   +4 more
wiley   +1 more source

A new MMP-mediated prodomain cleavage mechanism to activate bone morphogenetic proteins from the extracellular matrix. [PDF]

open access: yesFASEB J, 2021
Furlan AG   +8 more
europepmc   +1 more source

Current Trends and Future Prospects of Integrating Electrospinning With 3D Printing Techniques for Mimicking Bone Extracellular Matrix Scaffolds

open access: yesJournal of Polymer Science, Volume 63, Issue 6, Page 1481-1504, 15 March 2025.
ABSTRACT This article presents a review of the recent findings on the combination of electrospun nanofibers and three‐dimensional (3D)‐printed structures for extracellular matrix (ECM) scaffolds for bone tissue engineering. We explore the synergy between electrospinning (ES), which produces highly porous, fibrous structures from materials like collagen
Kardo Khalid Abdullah, Kolos Molnár
wiley   +1 more source

Genetic variants in bone morphogenetic proteins signaling pathway might be involved in palatal rugae phenotype in humans. [PDF]

open access: yesSci Rep, 2021
Silva-Sousa AC   +9 more
europepmc   +1 more source

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