Results 111 to 120 of about 1,467,095 (255)

Bone marrow-derived epithelial cells and hair follicle stem cells contribute to development of chronic cutaneous neoplasms

Nature Communications, 2018
Bone marrow-derived epithelial cells can be recruited to sites of chronic inflammation. Here, the authors using allogenic bone marrow transplantation in a multistage murine cutaneous carcinogenesis model show that bone marrow-derived epithelial cells and
Heuijoon Park, Sonali Lad, Kelsey Boland, Kelly Johnson, Nyssa Readio, Guangchun Jin, Samuel Asfaha, Kelly S. Patterson, Ashok Singh, Xiangdong Yang, Douglas Londono, Anupama Singh, Carol Trempus, Derek Gordon, Timothy C. Wang, Rebecca J. Morris   +15 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

P632: ORAL AND GUT MICROBIAL DIVERSITY CORRELATES WITH PROGNOSTIC FEATURES IN CHRONIC LYMPHOCYTIC LEUKEMIA

HemaSphere, 2022
M. Szelest, M. Paziewska, M. Kiełbus, M. Masternak, J. Zaleska, E. Wawrzyniak, E. Kalicińska, P. Jabłonowska, T. Wróbel, A. Wolska-Washer, J. Z. Błoński, K. Giannopoulos   +11 more
doaj   +1 more source

Issues in diagnosis of small B cell lymphoid neoplasms involving the bone marrow and peripheral blood. Report on the Bone Marrow Workshop of the XVIIth meeting of the European Association for Haematopathology and the Society for Hematopathology

, 2016
Small B cell lymphoid neoplasms are the most common lymphoproliferative disorders involving peripheral blood (PB) and bone marrow (BM). The Bone Marrow Workshop (BMW) organized by the European Bone Marrow Working Group (EBMWG) of the European Association
van der Walt, Jon, Kremer, Marcus,, Porwit, Anna,, Orazi, Attilio,, Fend, Falko,, Orazi, Attilio, Porwit, Anna, van der Walt, Jon,, Fend, Falko, Safali, Mükerrem,, Kremer, Marcus, Lund University., Safali, Mükerrem   +12 more
core   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

The Association Between JAK2V617F Mutation and Bone Marrow Fibrosis at Diagnosis in Patients with Philadelphia-Negative Chronic Myeloproliferative Neoplasms

, 2012
OBJECTIVE: Bone marrow fibrosis is the second most common complication causing morbidity and mortality in patients with Philadelphia negative myeloproliferative neoplasms (MPNs).
Aydin, Seniz Ongoren, Soysal, Teoman, A. Emre Eşkazan, Buyuktas, Deram, Burhan Ferhanoğlu, Ar, M. Cem, Ferhanoglu, Burhan, Deram Büyüktaş, Şeniz Öngören, Tuzuner, Nukhet, M. Cem Ar, Eskazan, A. Emre, Aydin, Yildiz, Zafer Başlar, Teoman Soysal, Eda Tanrıkulu, Yıldız Aydın, Buyru, A. Nur, Tanrikulu, Eda, Baslar, Zafer, A. Nur Buyru, Nükhet Tüzüner, Ar, Muhlis Cem   +22 more
core   +2 more sources

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Concentration of MMP-9, TNF-a and IL-6 in patients with tumors and tumor-like bone lesions [PDF]

Саратовский научно-медицинский журнал, 2017
Aim: to determine the concentration of MMP-9, TNF-a and IL-6 in blood serum of patients with benign and malignant bone tumors and feasibility of cytokine data use for differential diagnostics of the neoplastic process nature. Material and Methods. Levels
Puchinyan D.M., Pavlenko N.N., Korshunov G.V., Galashina E.A., Gladkova EV.   +4 more
doaj  

Extracellular vesicle-mediated cell–cell communication in haematological neoplasms

, 2017
Crosstalk between bone marrow tumour cells and surrounding cells, including bone marrow mesenchymal stromal cells (BM-MSCs), endothelial cells and immune cells, is important for tumour growth in haematological neoplasms.
Tomohiro Umezu, Kazuma Ohyashiki, Junko H. Ohyashiki   +2 more
core   +1 more source