Results 191 to 200 of about 196,593 (268)

Ascorbic Acid Modulates Collagen Properties in Glucocorticoid‐Induced Osteoporotic Bone: Insights into Chemical, Mechanical, and Biological Regulation

Advanced Healthcare Materials, EarlyView.
Osteoporosis from long‐term glucocorticoid (GIOP) use elevates susceptibility to fracture. This study shows GCs impair ascorbic acid (AA) metabolism in osteoblasts, collagen synthesis and extracellular matrix integrity. AA enhanced collagen biochemical and mechanical properties and restored osteoblast and endothelial function. These findings underscore
Micaila DE Curtis, Yoontae Kim, Rahul Patil, Xinran Zhang, Meth Jayatilake, Orelle Bulgin, Peter Lialios, Sana Surrency, Soraya Tarrah, Argyris K. Lazaris, Alison Grafton, James Williams IV, Seyedeh Boshra Nouraie, Maria Bizaki, Penelope Xeron, Edward Van Keuren, Jonathan E. Seppala, Evagelia C. Laiakis, Joanna B. Kitlinska, Stella Alimperti   +19 more
wiley   +1 more source

Functionalized metal-organic framework and MOF-derived materials for bone regeneration applications. [PDF]

Front Bioeng Biotechnol
Fan Y, Long C, Cai Y, Hu Y, Peng L.
europepmc   +1 more source

Co‐Delivery of Ca‐MOF and Mg‐MOF Using Nanoengineered Hydrogels to Promote In Situ Mineralization and Bone Defect Repair: In Vitro and In Vivo Analysis

Advanced Healthcare Materials, EarlyView.
Metal‐organic frameworks (MOFs) have been synthesized using calcium (Ca‐MOF), magnesium (Mg‐MOF), and as hybrids (Ca/Mg‐MOF) for bone healing applications. MOFs are integrated into hydrogel polymer networks for injectable, sprayable, and coating applications.
Cho‐E Choi, Chao Liang, Yasmeen Shamiya, Sang Jin Lee, Arghya Paul   +4 more
wiley   +1 more source

Carbon dots-based drug delivery for bone regeneration. [PDF]

Front Bioeng Biotechnol
Liu C, Li Y, Liu X.
europepmc   +1 more source

Natural‐Based Nanocomposite Ink Engineering for Seamless Multi‐Material Integration in Extrusion‐Based 3D Printing

Advanced Healthcare Materials, EarlyView.
This innovative ink engineering strategy enables the integration of bioactive nanocomposites into complex, multi‐material constructs. By combining primary chemical coupling and post‐printing photocuring, the study achieves tunable printability, seamless material integration, and robust mechanical performance.
João R. Maia, Miguel Bilo, Daniel S. Fidalgo, Pedro D. Rebolo, Ana S. Silva, Marco Parente, Rita Sobreiro‐Almeida, João F. Mano   +7 more
wiley   +1 more source

Thermosensitive antibacterial nanocomposite hydrogel guiding macrophage polarization and bone regeneration for periodontitis treatment. [PDF]

Bioact Mater
Yu X, Liu H, Chen L, Cheng X, Wu G, Forouzanfar T, Feng L, Guo R, Zhou M, Sun T.   +9 more
europepmc   +1 more source

Visible Light Induced DLP‐Printed Oxygen‐Releasing TPMS Scaffolds Mitigate Early Hypoxia in Bone Defects

Advanced Healthcare Materials, EarlyView.
Visible light‐induced digital light processing 3D printed Primitive‐triply periodic minimal surface hydrogels embed CaO2–Si core–shell nanoparticles to deliver short‐term oxygen during the avascular window. The scaffolds maintain cytocompatibility, elevate osteopontin in vitro, and enhance calvarial defect repair in vivo without toxicity.
Anastasia B. Timoshenko, Ali Ghasemkhani, Chanul Kim, Domenic J. Cordova, Maria Astudillo Potes, Valeria Aceves, Indranath Mitra, Justin E. Bird, Ryan S. Gray, Stephanie K. Seidlits, Benjamin D. Elder, Maryam Tilton   +11 more
wiley   +1 more source

Extracellular Vesicles in Osteogenesis: A Comprehensive Review of Mechanisms and Therapeutic Potential for Bone Regeneration. [PDF]

Curr Issues Mol Biol
Biswas S, Gangadaran P, Dhara C, Ghosh S, Phadikar SD, Chakraborty A, Mahajan AA, Mondal R, Chattopadhyay D, Banerjee T, Dey A, Ghosh S, Krishnan A, Ahn BC, Rajendran RL.   +14 more
europepmc   +1 more source

Shedding Light on the Cellular Uptake Mechanisms of Bioactive Glass Nanoparticles as Controlled Intracellular Delivery Platforms: A Review of the Recent Literature

Advanced Healthcare Materials, EarlyView.
This review summarizes the main uptake pathways of bioactive glass nanoparticles (BGNs) and their intracellular localization, highlighting that BGNs are mainly internalized and entrapped within endosomes/lysosomes. Strategies for controlled intracellular ion release, with implications for targeted modulation of cell behavior, are discussed. The need to
Andrada‐Ioana Damian‐Buda, Aldo R. Boccaccini   +1 more
wiley   +1 more source