The Involvement of microRNAs in Bone Remodeling Signaling Pathways and Their Role in the Development of Osteoporosis. [PDF]
Biology (Basel)Jiménez-Ortega RF +5 more
europepmc +1 more source
Advanced Science, EarlyView.This study develops RPTH by re‐modifying teriparatide and designs a biomimetic microstructured scaffold (BMRP) loaded with RPTH to address osteoporotic tendon‐to‐bone interface repair. The BMRP restores tissue architecture by balancing bone homeostasis and remodeling the microstructure, achieving functional recovery in an osteoporotic rotator cuff tear
Chengzhong Xu +11 more
wiley +1 more source
Sulfated galactofucan from Sargassum fusiforme protects against postmenopausal osteoporosis by regulating bone remodeling. [PDF]
Commun BiolYizhong B +5 more
europepmc +1 more source
Advanced Science, EarlyView.This work summarizes the efficacy and mechanisms of probiotics in CRC treatment, providing a comprehensive overview of various encapsulation methods such as microcapsules, hydrogels, single‐cell nanocoatings, and nanofibers for targeted probiotic delivery to inflammatory sites, with particular emphasis on the potential advantages of emerging single ...
Hao Zhong +5 more
wiley +1 more source
Bone remodeling markers: monitoring the changing bone. [PDF]
Adv Lab MedVaro N.
europepmc +1 more source
Advanced Science, EarlyView.A therapeutic strategy is proposed for periodontitis using extracellular vesicles derived from EPO‐stimulated macrophages (EPO‐EVs). This schema demonstrates how EPO‐EVs enhance the osteogenic activity of mBMSCs in an inflammatory environment by inhibiting EGFR.
Shuchen Liu +10 more
wiley +1 more source
RANKL-mediated osteoclastic subchondral bone loss at a very early stage precedes subsequent cartilage degeneration and uncoupled bone remodeling in a mouse knee osteoarthritis model. [PDF]
J Orthop Surg ResHashimoto T +6 more
europepmc +1 more source
The Role of MCPIP1 in Macrophage Polarization and Cardiac Function Post‐Myocardial Infarction
Advanced Science, EarlyView.Following myocardial infarction, MCPIP1 deficiency in macrophages triggers ferroptosis, driving proinflammatory M1 dominance over reparative M2 phenotypes. This imbalance amplifies splenic monocyte release and sustains cardiac inflammation. Concurrently, excessive inflammatory mediators and insufficient TGF‐β impair fibroblast activation, delaying ...
Xingxu Zhang +8 more
wiley +1 more source
MyD88 in osteoclast and osteoblast lineages differentially controls bone remodeling in homeostasis and malaria. [PDF]
Int ImmunolAlshaweesh J +12 more
europepmc +1 more source
Reinforcing Stromal Cell Spheroid Through Red‐Light Preconditioning for Advanced Vascularization
Advanced Science, EarlyView.This study presents a novel approach to enhance stromal cell therapy for myocardial infarction by combining OLED‐based photobiomodulation (OPBM) preconditioning with 3D spheroid culture of hADSCs. The engineered spheroids improve angiogenesis, arterialization, and cardiac function in vivo, offering a next‐generation therapeutic strategy to overcome ...
Yu‐Jin Kim +12 more
wiley +1 more source