Results 161 to 170 of about 1,847,810 (404)

Physiologic osteoclasts are not sufficient to induce skeletal pain in mice [PDF]

, 2020
Background: Increased bone resorption is driven by augmented osteoclast activity in pathological states of the bone, including osteoporosis, fracture and metastatic bone cancer.
De Clauser, L, Santana-Varela, S, Sikandar, S, Wood, JN   +3 more
core  

Single‐Cell Analysis Reveals that Vitamin C Inhibits Bone Metastasis of Renal Cancer via Cell Cycle Arrest and Microenvironment Remodeling

Advanced Science, EarlyView.
3D‐cultured renal cancer cells exhibit stem‐like phenotypes and are more efficient in generating bone metastases. Vitamin C treatment can suppress the development of bone metastasis. Single‐cell transcriptomic analysis reveals that vitamin C inhibits metastasis by inducing tumor cell cycle arrest, suppressing osteoclast differentiation, and reducing ...
Jianye Zhang, Qi Zhang, Gang Lin, Ying Wang, Juan Li, Ping Wang, Jie Qi, Yuan Liang, Shiming He, Yanqing Gong, Ninghan Feng, Yang Wang, Yuanyuan Ma, Mei Zhang, Yue Shi, Xuesong Li, Weimin Ci, Liqun Zhou   +17 more
wiley   +1 more source

Inhibitory Effects of 2N1HIA (2-(3-(2-Fluoro-4-Methoxyphenyl)-6-Oxo-1(6H)-Pyridazinyl)-N-1H-Indol-5-Ylacetamide) on Osteoclast Differentiation via Suppressing Cathepsin K Expression

Molecules, 2018
Osteoclasts are large multinucleated cells which are induced by the regulation of the receptor activator of nuclear factor kappa-Β ligand (RANKL), which is important in bone resorption.
Sun-Hee Ahn, Zhihao Chen, Jinkyung Lee, Seok-Woo Lee, Sang Hyun Min, Nam Doo Kim, Tae-Hoon Lee   +6 more
doaj   +1 more source

Initiation of Bone Resorption by the Classical and Alternative C Pathways and Its Mediation by Prostaglandins [PDF]

, 1977
Ann L. Sandberg, Lawrence G. Raisz, J. Max Goodson, Hollis A. Simmons, Stephan E. Mergenhagen   +4 more
openalex   +1 more source

Bacterial Capture‐Killing Capsules with Remodeling Bone Immune Microenvironment for the Effective Treatment of Osteomyelitis

Advanced Science, EarlyView.
The PC‐O@TOB capsules are designed to exhibit bactericidal effects, regulate the bone immune microenvironment by promoting M2 macrophage polarization, eliminate excessive ROS, and enhance bone regeneration, providing a novel multi‐dimensional approach for the treatment of osteomyelitis.
Dong Yang, Chang Shu, Chengwei Xu, Xingjie Zan, Shaoyin Wei, Chenglong Wang, Lianxin Li   +6 more
wiley   +1 more source

Mechanobiological regulation of bone remodeling -- Theoretical development of a coupled systems biology-micromechanical approach [PDF]

arXiv, 2012
Bone remodeling involves the coordinated removal of bone by osteoclasts and addition of bone by osteoblasts, a process that is modulated by the prevailing mechanical environment. In this paper a fully coupled model of bone remodeling is developed, based on coupling a bone cell population model with a micromechanical homogenization scheme of bone ...
arxiv  

The effects of varying oxygen tensions upon bone resorption in vitro [PDF]

, 1978
DH Gray, Katz Jm, K Speak
openalex   +1 more source

Gut Microbiota Modulates Obesity‐Associated Skeletal Deterioration Through Macrophage Aging and Grancalcin Secretion

Advanced Science, EarlyView.
Obese gut‐microbiota derived lipopolysaccharides (LPS) induce bone marrow macrophage senescence and GCA secretion via activating TLR4/NF‐κB/MAPKs pathway. Clinically, obese patients are associated with higher serum GCA levels. Mice with depletion of GCA gene show resistance to skeletal deterioration caused by obesity and LPS‐induced chronic ...
Min Huang, Mei Huang, Ling Liu, Fang Yang, Chen He, Yu‐Chen Sun, Yu‐Rui Jiao, Xiang Tang, Jing Hou, Kai‐Xuan Chen, Wen‐Zhen He, Jie Wei, Hui‐Ling Chen, Xia Li, Chao Zeng, Guang‐Hua Lei, Chang‐Jun Li   +16 more
wiley   +1 more source

Accuracy of vertical bitewing and bisect periapical radiography techniques in anterior mandibular teeth interdental bone resorption

مجله دانشکده دندانپزشکی اصفهان, 2009
Introduction: Alveolar bone level is changed due to the balance between bone formation and resorption. Radiographic examination has an important role in the diagnosis and treatment of periodontal diseases. This study was performed to compare the accuracy
Mohamad Shah Abouei, Ehsan Hekmatian E, Mahdi Adibrad, Ayoob Bahador Ghobadi   +3 more
doaj  

Ultrasound imaging of cortical bone: cortex geometry and measurement of porosity based on wave speed for bone remodeling estimation [PDF]

arXiv
Intracortical US imaging extends B-mode imaging into bone using a dedicated image reconstruction algorithm that corrects for refraction at the bone-soft tissue interfaces. It has shown promising results in a few healthy, predominantly young adults, providing anatomical images of the cortex (periosteal and endosteal surfaces) along with estimations of ...
arxiv