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Mechanisms involved in bone resorption
Biogerontology, 2002Osteoclasts, which are present only in bone, are multinucleated giant cells with the capacity to resorb mineralized tissues. These osteoclasts are derived from hemopoietic progenitors of the monocyte-macrophage lineage. Osteoblasts or bone marrow-derived stromal cells are involved in osteoclastogenesis through a mechanism involving cell-to-cell contact
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Bone Resorption in Human Cholesteatomas
Annals of Otology, Rhinology & Laryngology, 1982In vivo studies of different aspects of bone resorption in human cholesteatomas are described in the immunodeficient “nude” mice. Cholesteatoma membranes were transplanted into the middle ear cavities of the mice. After 21–28 days, growth of cholesteatoma tissue could be demonstrated in 8 of 13 animals.
Erik Dabelsteen +3 more
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Immunoreactive collagenase and bone resorption
Biochimica et Biophysica Acta (BBA) - General Subjects, 19811. Active mouse bone collagenase is excluded from its inhibitory antibody by preincubation of that antibody with various forms of inactive enzyme, e.g. 'procollagenase', some collagenase-inhibitor complexes or partially denatured or degraded collagenase. This property allows the detection of several enzymatically inactive forms of collagenase. 2.
Chantal Francois-Gillet +3 more
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Volume 2: Automotive Systems, Bioengineering and Biomedical Technology, Fluids Engineering, Maintenance Engineering and Non-Destructive Evaluation, and Nanotechnology, 2006
In the present paper a model for the resorption of bone, such as that observed at the interface between surgical implants and bone tissue, is developed. While there are many previous studies where models for bone remodelling calculations are proposed, these have been based on the stress or strain state of the bone tissue itself as the driving force for
Lars Johansson +3 more
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In the present paper a model for the resorption of bone, such as that observed at the interface between surgical implants and bone tissue, is developed. While there are many previous studies where models for bone remodelling calculations are proposed, these have been based on the stress or strain state of the bone tissue itself as the driving force for
Lars Johansson +3 more
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Increased bone resorption in hemophilia
Blood Reviews, 2019In patients with hemophilia, osteoporosis is frequently observed for which the etiology remains unclear. The aim of this paper is to review the available experimental evidence indicating the presence of this disorder in patients with hemophilia, explore the potential mechanisms which may lead to reduced bone mineral density (BMD) and speculate on ...
Leonard A. Valentino +1 more
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Particles and Periimplant Bone Resorption
Clinical Orthopaedics and Related Research, 2002There is compelling evidence that the most important factor in late periprosthetic bone resorption is an inflammatory reaction to debris. Based on results from several laboratories, it seems likely that opsonized particles activate the macrophage nuclear factor-kappa B signal transduction system via membrane receptors, leading to release of tumor ...
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Bone Resorption of the Distal Clavicle
JAMA: The Journal of the American Medical Association, 1979History An abnormality of the distal left clavicle was identified on a routine chest film of a professional hockey player, and this was confirmed on a shoulder roentgenogram (Fig 1). He denied pain or weakness in the left arm. Diagnosis Traumatic osteolysis of the distal end of the clavicle. Comment The shoulder films (Fig 1 and 2) show resorption
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Molecular mechanisms of bone resorption
Journal of Cellular Biochemistry, 1995AbstractThis review focuses on osteoclast ontogeny and function, emphasizing three aspects. We describe how a combination of laboratory models available to study the cell plus examination of the osteopetroses, a family of sclerotic diseases of the skeleton, have yielded major insights into osteoclast ontogeny and function.
Yousef Abu-Amer +2 more
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The Cellular Basis of Bone Resorption
Clinical Orthopaedics and Related Research, 1980The osteoclast is the major agent of bone resorption. Durang the last few years persuasive evidence has emerged from several sources which shows that the osteoclast is derived from the fusion of cells of the mononuclear phagocyte system. This fact makes a reevaluation of the pathophysiology of bone resorption necessary. The most plausible mechanism for
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Role of cytokines in bone resorption
Bone, 1995It has been established during the past few years that interleukin(s)-1, -6, -11 (IL-1, IL-6, IL-11), and tumor necrosis factor (TNF) can stimulate osteoclast development and thereby the process of bone resorption. Moreover, upregulation of the production and/or action of IL-6 has been implicated in the pathogenesis of disease states characterized by ...
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