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Bone Resorption by Osteoclasts
Science, 2000Osteoporosis, a disease endemic in Western society, typically reflects an imbalance in skeletal turnover so that bone resorption exceeds bone formation. Bone resorption is the unique function of the osteoclast, and anti-osteoporosis therapy to date has targeted this cell.
S. Teitelbaum
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The Lancet, 1979
The cell-system responsible for resorption of bone is now considered to be a derivative of haematopoietic bone-marrow, not skeletal connective tissue. Consideration of mutant mice and rats, with defects of bone resorption giving osteopetrosis, suggests that the primary defect is of the professional scavengers, the mononuclear-phagocyte system, failing ...
J F, Loutit, N W, Nisbet
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The cell-system responsible for resorption of bone is now considered to be a derivative of haematopoietic bone-marrow, not skeletal connective tissue. Consideration of mutant mice and rats, with defects of bone resorption giving osteopetrosis, suggests that the primary defect is of the professional scavengers, the mononuclear-phagocyte system, failing ...
J F, Loutit, N W, Nisbet
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BONE RESORPTION IN OTOSPONGIOSIS
Otology & Neurotology, 1982"Considerable interest has been raised in recent years concerning the basic mechanisms involved in bone destruction and rebuilding in the otospongiotic focus. Under general bone resorption the osteoclasts play a decisive role, but in otospongiotic tissue electron-microscopic and cytochemical studies have shown that osteoclasts alone are not responsible
P, Bretlau +3 more
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Journal of Cellular Biochemistry, 2018
Osteoclasts are highly differentiated terminal cells formed by fusion of hematopoietic stem cells. Previously, osteoprotegerin (OPG) inhibit osteoclast differentiation and bone resorption by blocking receptor activator of nuclear factor‐κB ligand (RANKL)
Xishuai Tong +9 more
semanticscholar +1 more source
Osteoclasts are highly differentiated terminal cells formed by fusion of hematopoietic stem cells. Previously, osteoprotegerin (OPG) inhibit osteoclast differentiation and bone resorption by blocking receptor activator of nuclear factor‐κB ligand (RANKL)
Xishuai Tong +9 more
semanticscholar +1 more source
Barbiturate and bone resorption
Calcified Tissue International, 1995Os teopenia , r ickets , and/or o s t eoma lac i a have been observed in patients chronical ly t reated with ant iconvulsant drugs. Part of these bone disorders have been related to an ant iconvulsantinduced al terat ion of vi tamin D metabol ism [1, 2].
M, Petrovic, G, Cournot
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Superoxide and bone resorption
Bone, 1994The reaction of superoxide with nitroblue tetrazolium produces an electron-dense diformazan precipitate which can be used to localize areas of superoxide production. Transmission electron microscopy was used to demonstrate that diformazan granules formed by the reaction of nitroblue tetrazolium with excess superoxide are electron dense, whereas ...
L L, Key +3 more
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Bone resorption and prosthodontics
The Journal of Prosthetic Dentistry, 1973Abstract The phenomenon of bone resorption and its importance to dentistry, specifically prosthodontics, have been briefly reviewed. At a skeletal level, bone resorption is thought to be controlled by the opposing actions of parathyroid hormone and thyrocalcitonin. The importance of vitamin D and phosphate in this mechanism was discussed.
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