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Bone resorption and bone metastasis risk

Medical Hypotheses, 2018
Breast cancer tumors have a tendency to metastasize to the bone. After development of a bone metastasis, the median survival time is 40 months. Currently, little is known about the modifiable risk factors for developing bone metastases in women diagnosed with breast cancer. One possible modifiable risk factor is increased bone resorption.
Katlynn M, Mathis   +5 more
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Bone deposition, bone resorption, and osteosarcoma

Journal of Orthopaedic Research, 2010
AbstractBone deposition and bone resorption are ongoing dynamic processes, constituting bone remodeling. Some bone tumors, such as osteosarcoma (OS), stimulate focal bone deposition. OS is the most common primary bone tumor in children and young adults.
Sílvia Regina Caminada, Toledo   +7 more
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Stimulative effects of cadmium on bone resorption in neonatal pariental bone resorption

Toxicology, 1992
Effects of cadmium on bone resorption were investigated using neonatal mouse parietal bone culture system. Cadmium at 0.5 microM and above stimulated hydroxyproline release as well as 45Ca release. As cadmium-stimulated bone resorption was inhibited by calcitonin, bone resorption induced by cadmium is osteoclast-mediated bone resorption.
T, Miyahara   +8 more
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Resorption characteristics of bone and bone substitutes

Oral Surgery, Oral Medicine, Oral Pathology, 1964
Abstract Resorption of ninety intramuscular implants of different types of bone and bone substitutes were studied radiographically in twenty-two adult mongrel dogs. On the basis of mean resorption time, the implants were resorbed in the following order: (1) plaster of Paris, (2) autogenous cancellous bone, (3) cathode-ray-sterilized canine cancellous
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Cortical Bone Resorption in Osteoporosis

Calcified Tissue International, 1997
A study was made of 110 women: 35 healthy premenopausal, 40 healthy postmenopausal, and 35 women diagnosed as having postmenopausal osteoporosis. The postmenopausal women had similar ages and years since menopause (YSM). In all of the women, total bone mass was evaluated by dual-energy X-ray absorptiometry and metacarpal morphometry was evaluated by ...
F, Aguado   +3 more
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The effect of insulin on bone resorption

Calcified Tissue Research, 1973
the administration of crystalline insulin to thyroparathyroidectomized rats raised their calcium and phosphorus plasma levels. The plasma calcium gave a linear response between 31 and 250 mU of insulin/100 g body weight. The slope obtained is not significantly different from that obtained with parathyroid extract.
R C, Puche   +3 more
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Immunoreactive collagenase and bone resorption

Biochimica et Biophysica Acta (BBA) - General Subjects, 1981
1. Active mouse bone collagenase is excluded from its inhibitory antibody by preincubation of that antibody with various forms of inactive enzyme, e.g. 'procollagenase', some collagenase-inhibitor complexes or partially denatured or degraded collagenase. This property allows the detection of several enzymatically inactive forms of collagenase. 2.
C, Francois-Gillet   +3 more
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Bone Resorption in Human Cholesteatomas

Annals of Otology, Rhinology & Laryngology, 1982
In vivo studies of different aspects of bone resorption in human cholesteatomas are described in the immunodeficient “nude” mice. Cholesteatoma membranes were transplanted into the middle ear cavities of the mice. After 21–28 days, growth of cholesteatoma tissue could be demonstrated in 8 of 13 animals.
P, Bretlau   +3 more
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THE RESORPTION OF BONE

Archives of Surgery, 1930
The earliest workers in bone were concerned with its resorption. Howship, 1 in 1815 and 1817, discussed physiologic and pathologic resorption, but others before him had already called attention to this subject. Later, Koelliker, 2 using the newer methods of histologic technic, applied himself especially to a study of physiologic resorption and ...
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Mechanisms involved in bone resorption

Biogerontology, 2002
Osteoclasts, which are present only in bone, are multinucleated giant cells with the capacity to resorb mineralized tissues. These osteoclasts are derived from hemopoietic progenitors of the monocyte-macrophage lineage. Osteoblasts or bone marrow-derived stromal cells are involved in osteoclastogenesis through a mechanism involving cell-to-cell contact
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