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Increased bone resorption in hemophilia
Blood Reviews, 2019In patients with hemophilia, osteoporosis is frequently observed for which the etiology remains unclear. The aim of this paper is to review the available experimental evidence indicating the presence of this disorder in patients with hemophilia, explore the potential mechanisms which may lead to reduced bone mineral density (BMD) and speculate on ...
Leonard A. Valentino +1 more
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Molecular mechanisms of bone resorption
Journal of Cellular Biochemistry, 1995AbstractThis review focuses on osteoclast ontogeny and function, emphasizing three aspects. We describe how a combination of laboratory models available to study the cell plus examination of the osteopetroses, a family of sclerotic diseases of the skeleton, have yielded major insights into osteoclast ontogeny and function.
Yousef Abu-Amer +2 more
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Role of cytokines in bone resorption
Bone, 1995It has been established during the past few years that interleukin(s)-1, -6, -11 (IL-1, IL-6, IL-11), and tumor necrosis factor (TNF) can stimulate osteoclast development and thereby the process of bone resorption. Moreover, upregulation of the production and/or action of IL-6 has been implicated in the pathogenesis of disease states characterized by ...
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Coupling of bone resorption and formation by RANKL reverse signalling
Nature, 2018Yuki Ikebuchi +12 more
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Immune Cells and Bone Resorption
1986The concept of interactions between cells of the immune system and bone in the control of bone turnover is far from new. The relationship between haematopoietic precursor cells and the osteoclast has long been recognised and studies on animals with congenital bone diseases such as osteopetrosis have identified defective components of the immune system ...
D. E. Hughes +4 more
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The Cellular Basis of Bone Resorption
Clinical Orthopaedics and Related Research, 1980The osteoclast is the major agent of bone resorption. Durang the last few years persuasive evidence has emerged from several sources which shows that the osteoclast is derived from the fusion of cells of the mononuclear phagocyte system. This fact makes a reevaluation of the pathophysiology of bone resorption necessary. The most plausible mechanism for
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Bone Formation and Resorption in Bone Disorders
1966The recognition of the majority of disorders of skeletal bone depends largely upon their radiological appearance. The various pathological processes may then be further differentiated by alteration in such biochemical parameters as the plasma calcium and phosphorus levels.
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Mechanisms of joint destruction in rheumatoid arthritis — immune cell–fibroblast–bone interactions
Nature Reviews Rheumatology, 2022N. Komatsu, H. Takayanagi
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The Journal of Prosthetic Dentistry, 1960
Abstract Alveolar bone resorption is one of the most important phenomena in denture construction. Some of the factors to be considered are: 1.1. Alveolar bone resorption after extractions is a normal process. 2.2. The patient's history may reveal systemic diseases which might cause resorption through circulatory disturbances or faulty metabolism ...
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Abstract Alveolar bone resorption is one of the most important phenomena in denture construction. Some of the factors to be considered are: 1.1. Alveolar bone resorption after extractions is a normal process. 2.2. The patient's history may reveal systemic diseases which might cause resorption through circulatory disturbances or faulty metabolism ...
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LGR4 is a receptor for RANKL and negatively regulates osteoclast differentiation and bone resorption
Nature Network Boston, 2016Jian Luo +18 more
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