PIM447, a Pan-PIM Kinase Inhibitor, in Combination with Venetoclax Exerts a Potent Anti-Tumor Activity in the Bone Marrow Niche [PDF]
Fernanda Marconi Roversi +10 more
openalex +1 more source
Cross‐Scale Hierarchical Targeted Delivery System Based on Small‐Scale Magnetic Robots
This article reviews a cross‐scale hierarchical targeted delivery system that integrates magnetic continuum robots and magnetic microrobots. By combining rapid long‐range navigation with precise microscale targeting, the system overcomes key limitations of single‐scale approaches.
Junjian Zhou +4 more
wiley +1 more source
Minimally invasive steam-assisted drug delivery with ICG fluorescence guidance for primary malignant bone tumors and evaluation of clinical applicability. [PDF]
Lee SM, Yoon K, Lee S, Kang HG, Kim KG.
europepmc +1 more source
DRD2 Deficiency Underlies Pituitary Adenoma Dependent on Escherichia coli Translocation from the Gut
Dopamine receptor D2 (DRD2) deficiency disrupts epithelial barrier integrity in both the gut and pituitary gland, facilitating translocation of gut‐derived Escherichia coli into pituitary tissue. Intratumoral E. coli are phagocytosed by microglia, triggering GSDMD‐dependent pyroptosis and HMGB1 release, which subsequently activates MAPK signaling to ...
Xian‐jun Su +16 more
wiley +1 more source
Lower Limb Biomechanical Outcomes Following Endoprosthetic Reconstruction for Distal Femur and Proximal Tibia Bone Tumors: A Systematic Review and Meta-Analysis. [PDF]
Gao Y +7 more
europepmc +1 more source
Fibroblast activation protein alpha‐positive (FAPα+) macrophages, a distinct subset of multiple myeloma (MM)‐associated macrophages, drive immune evasion in MM through multi‐faceted mechanisms. FAPα physically interacts with vimentin (VIM) and triggers its phosphorylation at the S72 residue, which in turn induces PD‐L1 transcription. Additionally, FAPα
Huiyao Gu +15 more
wiley +1 more source
Comparative assessment of sarcopenia screening tools for patients with bone tumors: insights for enhanced clinical application. [PDF]
Yu J +5 more
europepmc +1 more source

